A5036801791- Colorectal Cancer Surgical Treatments
- Anorectal Disease Treatments and Outcomes
- Colorectal and Anal Carcinomas
- Colorectal Cancer Screening and Detection
- Heat shock proteins research
- Endoplasmic Reticulum Stress and Disease
- Surgical Simulation and Training
- Pelvic and Acetabular Injuries
- Anatomy and Medical Technology
- Gastric Cancer Management and Outcomes
- Radiomics and Machine Learning in Medical Imaging
- Colorectal Cancer Treatments and Studies
- Pelvic floor disorders treatments
- Advanced X-ray and CT Imaging
- Minimally Invasive Surgical Techniques
- Hernia repair and management
- Immune Response and Inflammation
- Telemedicine and Telehealth Implementation
- Immunotherapy and Immune Responses
- ATP Synthase and ATPases Research
- Immune Cell Function and Interaction
- Gastrointestinal Tumor Research and Treatment
- German Social Sciences and History
- Autophagy in Disease and Therapy
- Surgical site infection prevention
Sapporo Medical University
2014-2025
The Japanese Society of Gastroenterological Surgery
2022
Otsu Municipal Hospital
2013
Otaru Municipal Hospital
2005
Sapporo University
2005
The hinotori Surgical Robot System obtained pharmaceutical approval for use in colorectal cancer surgery October 2022 Japan, and its advantages, including operating arm with eight axes, adjustable base, flexible 3D viewer, are expected to be utilized colon surgery. A 68-year-old woman presented our hospital abdominal pain was diagnosed cStageIIa (cT3N0M0) ascending underwent right hemicolectomy using the appropriate port placement on arc around hepatic flexure, which available both ileocecal...
The hinotori™ Surgical Robot System was approved for use in colorectal cancer surgery Japan 2022. This robot has advantages, such as an operation arm with eight axes, adjustable base, and a flexible three-dimensional viewer, is expected to be utilized rectal surgery. Herein, we report the world's first using System.A 71-year-old woman presented our hospital bloody stools. A colonoscopy revealed type 2 advanced rectum, histological examination exposed well-differentiated adenocarcinoma....
Abstract Background Accurate identification of tumor sites during laparoscopic colorectal surgery helps to optimize oncological clearance. We aimed assess the timing local injection preoperatively and clarify usefulness limitation site marking using indocyanine green (ICG) fluorescence imaging. Methods Consecutive patients who underwent primary cancer from September 2017 January 2019 were included. Preoperatively, lower endoscopy was used inject ICG solution into submucosal layer near tumor....
Although MRI has a substantial role in directing treatment decisions for locally advanced rectal cancer, precise interpretation of the findings is not necessarily available at every institution. In this study, we aimed to develop artificial intelligence-based software segmentation cancer that can be used staging optimize strategy and preoperative surgical simulation.Images from total 201 patients who underwent were analyzed training data. The resected specimen was processed circular shape...
An artificial intelligence-based algorithm we developed, mrAI, satisfactorily segmented the rectal tumor, rectum, and mesorectum from MRI data of cancer patients in an initial study. Herein, aimed to validate mrAI using independent dataset.
Abstract ERO1-α is an oxidizing enzyme that exists in the endoplasmic reticulum and induced under hypoxia. It reoxidizes reduced form of protein disulfide isomerase has oxidized target proteins. We found overexpressed a variety tumor types. MHC class I H chain (HC) two bonds α2 α3 domains. HC folding linked to assembly molecules because only fully disulfide-bonded HCs efficiently assemble with β2-microglobulin. In this study, we show associates isomerase, calnexin, immature before being...
Systemic lupus erythematosus (SLE) is a prototype systemic autoimmune disease, and disease activity associated with serum IFN-α level. Plasmacytoid dendritic cells (pDCs) sense microbial as well self-nucleic acids by TLRs 7 9 produce large amount of IFN-α. Here, we show that heat shock protein 90 (Hsp90) associates delivers TLR7/9 from the ER to early endosomes for ligand recognition. Inhibition Hsp90 various approaches including use inhibitor, geldanamycin derivative, suppressed association...
Recent studies have suggested that TLR9 signaling in early endosomes leads to IFN-alpha production by plasmacytoid dendritic cells (pDCs), whereas late induces pDC maturation, IL-6, and TNF-alpha secretion. In this study, we show human DNA as well CpG-oligodeoxynucleotides (ODNs) complex with heat shock protein 90 (Hsp90) stimulate pDCs produce large quantities of IFN-alpha. The Hsp90-CpG-A complexes are targeted into the Rab5+, endosomal Ag 1+-static endosome postinternalization DCs,...
Aim In computed tomography colonography angiography (CTC-A), used for preoperative screening of right-sided colon cancer, the timing venous phase imaging is conventionally determined by a fixed-delay time; however, contrast effect may be insufficient because individual differences in blood flow status. Therefore, we developed double-bolus tracking (DBT) method to solve this issue. Method We compared and image quality portal systems between two methods conventional DBT which utilizes low-dose...
ABSTRACT The da Vinci Single‐Port (dV‐SP) is an innovative robot that integrates the advantages of articulated robotic instruments and a single access approach. A 58‐year‐old man who presented to our hospital with abdominal pain was diagnosed cStageIIc (cT4bN0M0) rectal cancer underwent abdominal‐perineal resection using dV‐SP. Its characteristic properties (cobra position camera, wrists elbows, relocating) allowed surgeons overcome challenges associated single‐port laparoscopic surgery,...
To establish an effective cancer immunotherapy, it is crucial that cells present a cancer-specific antigen in hypoxic area, hallmark of the tumor microenvironment. Here, we show impact hypoxia on MHC class I presentation vitro and vivo murine tumors. Activation antigen-specific CTLs by had been pre-incubated under condition was enhanced compared with normoxia. Cell surface expression I-peptide complex increased hypoxia, thereby leading to higher susceptibility specific CTLs. We...
Heat shock proteins (HSPs) such as Hsp70, gp96, and Hsp90 have been shown to elicit intriguing, efficient CTL responses by cross-presentation via an yet entirely unknown mechanism. Oxygen-regulated protein 150 (ORP150), also known grp170, is endoplasmic reticulum-resident HSP up-regulated hypoxia. It has demonstrated that ORP150 binds tumor-associated Ag peptides within cancer cells. Immunization with ORP150-tumor complex generate tumor-specific CTLs. Most recently, it exogenous induces of a...
In May 2023, the Hugo RAS system obtained pharmaceutical approval for use in gastroenterological surgery Japan. It is expected to be particularly effective rectal cancer surgery, which require manipulation of deep pelvic cavity and communication with surgeons operating from intraperitoneal anal approaches. A 68-year-old woman presented our hospital bloody stools was diagnosed cStage I (cT2N0M0) underwent abdominoperineal resection employing system. Two arm carts were placed on left right...
The presentation of an exogenous antigen in a major histocompatibility complex class-I- restricted fashion to CD8(+) T cells is called cross-presentation. Heat shock proteins (HSPs) such as Hsp70, gp96, and Hsp90 have been shown elicit efficient CTL responses by cross-presentation through as-yet entirely unknown mechanism. the most abundant cytosolic HSP known act molecular chaperone. We that tumor peptide complexed with could be cross-presented dendritic (DCs) endosomal pathway murine...
A new technique that allows visualization of whole pelvic organs with high accuracy and usability is needed for preoperative simulation in advanced rectal cancer surgery. In this study, we developed an automated algorithm to create a three-dimensional (3D) model from MRI using artificial intelligence (AI) technology.
Abstract Aim The aim of this study was to verify the clinical feasibility tele‐proctoring using our ultra‐low latency communication system with shared internet access. Methods Connections between two multiple remote locations at various distances were established through TELEPRO® system. server records for annotations. Questionnaires administered surgeons, assistants, and medical staff. Respondents rated quickness quality in terms disturbances audio, video, usefulness live telestrations...