A5010321639- Autophagy in Disease and Therapy
- Cell Adhesion Molecules Research
- Protein Kinase Regulation and GTPase Signaling
- Multiple Sclerosis Research Studies
- HER2/EGFR in Cancer Research
- Ubiquitin and proteasome pathways
- Immunotherapy and Immune Responses
- Genetics, Aging, and Longevity in Model Organisms
- T-cell and B-cell Immunology
- Glycosylation and Glycoproteins Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Immune Cell Function and Interaction
- Amyotrophic Lateral Sclerosis Research
- RNA Interference and Gene Delivery
- Cancer-related Molecular Pathways
- Cell death mechanisms and regulation
- Polyomavirus and related diseases
- Neurological Disorders and Treatments
- Educational Methods and Impacts
- RNA Research and Splicing
- Microtubule and mitosis dynamics
- Toxoplasma gondii Research Studies
- Calcium signaling and nucleotide metabolism
- Inflammation biomarkers and pathways
- Melanoma and MAPK Pathways
Copenhagen University Hospital
2022-2025
Rigshospitalet
2022-2025
Danish Multiple Sclerosis Center
2022-2025
University of Copenhagen
2002-2022
University Hospital Münster
2022
Danish Cancer Society
2018-2021
University of Southern Denmark
2016
University of California, San Francisco
2003-2008
Scripps Research Institute
2003
Gentofte Hospital
1996
In many organisms, dietary restriction appears to extend lifespan, at least in part, by down-regulating the nutrient-sensor TOR (Target Of Rapamycin). inhibition elicits autophagy, large-scale recycling of cytoplasmic macromolecules and organelles. this study, we asked whether autophagy might contribute lifespan extension induced C. elegans. We find that produce an autophagic phenotype inhibiting genes required for prevents from extending lifespan. The longevity response elegans requires...
Autophagy is a cytoplasmic catabolic process that protects the cell against stressful conditions. Damaged cellular components are funneled by autophagy into lysosomes, where they degraded and can be re-used as alternative building blocks for protein synthesis repair. In contrast, aging gradual failure over time of repair mechanisms leads to accumulation molecular damage loss function. The cell's capacity autophagic degradation also declines with age, this in itself may contribute process....
Most studies investigating chromium allergy have been performed with Cr(VI). However, real exposure to from leather products includes both Cr(III) and We determined compared the minimum elicitation threshold (MET) concentration for Cr(VI) in Cr(VI)-sensitive patients. In addition, reactions combinations of were elicited by alone. Dilution series applied Finn Chambers on back 18 The patches left 2 days readings done 2, 3 7. MET10% was calculated dose-response curves be 0.18 microg/cm2/48 h (6...
Background and Objectives Follicular helper T (Tfh) cells play a critical role in protective immunity helping B produce antibodies against foreign pathogens are likely implicated the pathogenesis of various autoimmune diseases. The purpose this study was to investigate Tfh multiple sclerosis (MS). Methods Using flow cytometry, we investigated phenotype, prevalence, function blood CSF from controls patients with relapsing-remitting MS (RRMS) primary progressive (PPMS). In addition, an vitro...
Cerebrospinal fluid (CSF) soluble CD27 (sCD27) is a sensitive biomarker of intrathecal inflammation. Although generally considered T cell activation, CSF sCD27 has been shown to correlate with biomarkers B activity in multiple sclerosis. We analyzed from 40 patients relapsing-remitting sclerosis (RRMS) and nine symptomatic controls using flow cytometry multiplex electrochemiluminescence immunoassays. levels were increased RRMS correlated IgG index, maturation antigen, count, frequency CD8+...
Cancer cells utilize lysosomes for invasion and metastasis. Myeloid Zinc Finger1 (MZF1) is an ErbB2-responsive transcription factor that promotes of breast cancer via upregulation lysosomal cathepsins B L. Here we identify let-7 microRNA, a well-known tumor suppressor in cancer, as direct negative regulator MZF1. Analysis primary tissues reveals gradual MZF1 from normal epithelium to invasive ductal carcinoma correlation between several family members mRNA, suggesting the inverse regulatory...
The rapid modulation of ligand-binding affinity ("activation") is a central property the integrin family cell adhesion receptors. Ras small GTP-binding proteins and their downstream effectors are key players in regulating activation. H-Ras can suppress activation fibroblasts via its effector kinase, Raf-1. In contrast, to H-Ras, closely related protein R-Ras has opposite activity, promotes To gain insight into regulation by GTPases, we created series H-Ras/R-Ras chimeras. We found that...
Follicular helper T (Tfh) cells and their interplay with B likely contribute to the pathogenesis of relapsing-remitting multiple sclerosis (RRMS). Tfh are enriched in cerebrospinal fluid (CSF) RRMS, but effects anti-CD20 therapy unknown. We investigated controls, untreated anti-CD20-treated patients RRMS using flow cytometry. CSF were increased patients. Compared paired blood samples, CD25
Early and accurate diagnosis of neurocognitive disorders including neurodegenerative dementia remains challenging. This study explores the impact biological factors on serum neurofilament light chain (NfL) levels clinical usefulness for detection in a mixed memory clinic.
Trichoderma viride (Tv) is often found in damp and mouldy buildings where people complain of adverse health effects including mucosal/respiratory symptoms. Inhaled spores can reach the alveoli may interact with airway epithelium. An interaction mucosal mast cells was studied obtained by bronchoalveolar lavage (BAL) from 18 individuals. The fungal were to trigger histamine release BAL cells, but relatively high concentrations (0.1-2 mg/ml) needed. A similar dose response basophil release....
GAGE cancer/testis antigens are frequently expressed in various types of malignancies and represent attractive targets for immunotherapy, however their role cancer initiation progression has remained elusive. proteins normal cells during early development with migratory invasive properties were found to be upregulated metastasizing potential a gastric model. We have addressed the direct supporting metastasis using an isogenic model human cancer, consisting 4 cell lines, which equally...
Dimethyl fumarate treatment is approved in Europe for patients with relapsing-remitting multiple sclerosis (MS) and the US relapsing forms of MS. We recently published results first randomized placebo-controlled trial 48 weeks dimethyl or placebo primary progressive MS (PPMS) (clinicaltrial.gov NCT02959658). The phase did not meet its endpoint (reduction cerebrospinal fluid concentrations neurofilament light chain [NFL]).To investigate effects open-label extension (week 48-96), where all...
Abstract Purpose Most HER2 positive invasive cancers are either intrinsic non-responsive or develop resistance when treated with 1st line targeting drugs. Both and 2nd treatments of aimed at the receptor directly, thereby strongly limiting treatment options HER2/ErbB2 inhibition resistant cancers. Methods We used phenotypic high throughput microscopy screening to identify efficient inhibitors ErbB2-induced invasion using inhibitor trastuzumab- pertuzumab-resistant, p95-ErbB2 expressing...
<title>Abstract</title> Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system (CNS). In MS, CNS-infiltrating monocytes differentiate to tissue resident macrophages which are found in large numbers within injured areas brain where they play role driving progression through demyelination and destruction. However, infiltrating their derivative can also serve protective functions. this study we investigated possible intrathecal mononuclear phagocytes...
Abstract Up to 20% of all breast cancers are over-expressing HER2/ErbB2, leading malignant and invasive with a poor patient outcome. Though good ErbB2-targeting treatments have been developed, metastasis formation drug resistance still major challenges for the long-term cure. This project aims find out if some numerous pre-existing compounds clinically approved drugs can be repurposed treat or improve treatment HER2/ErbB2-positive cancer. We therefore set up high-throughput high-content...
Up to 20% of all breast cancers are over-expressing HER2/ErbB2, leading malignant and invasive with a poor patient outcome. Though good ErbB2-targeting treatments have been developed, metastasis formation drug resistance still major challenges for the long-term cure. This project aims find out if some numerous pre-existing compounds clinically approved drugs can be repurposed treat or improve treatment HER2/ErbB2-positive cancer. We therefore set up high-throughput high-content screen...