A5013506324- Pregnancy and preeclampsia studies
- Birth, Development, and Health
- Gestational Diabetes Research and Management
- Folate and B Vitamins Research
- Reproductive System and Pregnancy
- Iron Metabolism and Disorders
- COVID-19 Impact on Reproduction
- Pregnancy and Medication Impact
- Nutritional Studies and Diet
- Assisted Reproductive Technology and Twin Pregnancy
- Pelvic floor disorders treatments
- Neonatal Respiratory Health Research
- Maternal and Perinatal Health Interventions
- Gynecological conditions and treatments
- Hemoglobinopathies and Related Disorders
- Prenatal Screening and Diagnostics
- Neonatal and fetal brain pathology
- Ectopic Pregnancy Diagnosis and Management
- Endometriosis Research and Treatment
- Uterine Myomas and Treatments
- Fetal and Pediatric Neurological Disorders
- COVID-19 and healthcare impacts
- Fluoride Effects and Removal
- Homicide, Infanticide, and Child Abuse
- Temporomandibular Joint Disorders
Ospedale Maggiore
2020-2025
Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico
2020-2025
University of Milan
2016-2025
ASST Fatebenefratelli Sacco
2018-2024
University of Perugia
2023
Ospedale dei Bambini Vittore Buzzi
2022
Ospedale Policlinico San Martino
2022
Luigi Sacco Hospital
2012-2021
Community Link
2020
University of Milano-Bicocca
2020
To investigate the clinical evolution of coronavirus disease 2019 (COVID-19) in hospitalized pregnant women and potential factors associated with severe maternal outcomes.We designed a prospective multicenter cohort study acute respiratory syndrome 2 (SARS-CoV-2) infection who were admitted to 12 Italian maternity hospitals between February 23 March 28, 2020. Clinical records, laboratory radiologic examinations, pregnancy outcomes collected. A subgroup patients was identified based on...
Abstract Background Growing evidence demonstrates that maternal nutrition is crucial for the health of mother-to-be, and early life course offspring. However, most micronutrients, guidelines are inconsistent. This Delphi study aimed to investigate level expert consensus on micronutrient needs during preconception, pregnancy lactation. Methods We conducted a two-round web-based survey various topics including general approaches diet supplement use, existing guidelines. For periods lactation,...
Intrauterine growth restriction (IUGR) and pregnancy hypertensive disorders such as preeclampsia (PE) associated with IUGR share a common placental phenotype called “placental insufficiency”, originating in early gestation when high availability of energy is required. Here, we assess mitochondrial content the expression activity respiratory chain complexes (RCC) cells these pathologies. We measured (mt)DNA nuclear factor 1 ( NRF1) tissue cytotrophoblast cells, gene protein expressions RCC...
During intrauterine life, external stimuli including maternal nutrition, lifestyle, socioeconomic conditions, anxiety, stress, and air pollution can significantly impact fetal development. The human brain structures begin to form in the early weeks of gestation continue grow mature throughout pregnancy. This review aims assess, based on latest research, environmental factors neonatal development, showing that oxidative stress inflammation are implied as a common factor for most stressors....
Purpose: Iron supplementation is associated with side effects and overload risk. We compared different regimens of iron on maternal hematological status pregnancy outcome in a cohort healthy pregnant women.Materials methods: Eighty non-anemic women normal singleton were recruited at 11–13 weeks randomized into controls (C; n = 20) groups supplemented ferrous 30 mg (FI; 20), liposomal 14 (Sideral® Pharmanutra, Pisa PI, Italy) (LI14; 28 mg/daily (LI28; up to 6 post-partum. Longitudinal blood...
The aim is to evaluate changes in the volume of upper airways before and after slow maxillary expansion (SME) obtained with flexible properties a nickel titanium leaf spring rapid (RME) conventional Hyrax appliance growing patients. records 1200 orthodontic patients undergoing from 2018 2019 were analyzed; among these pre post treatment CBCT scans 22 (mean age 8.2 ± 0.6 years old) treated by SME compared those 8.1 0.7 RME banded on second primary molars. following inclusion criteria used:...
MicroRNAs are gene expression regulators associated with several human pathologies, including those generated by viral infections. Their role in SARS-CoV-2 infection and COVID-19 has been investigated reviewed many informative studies; however, a thorough miRNA outline SARS-CoV-2-infected pregnant women (SIPW), at both systemic placental levels, is missing. To fill this gap, blood placenta biopsies collected delivery from 15 asymptomatic SIPW were immediately analysed for: (n = 84) (QPCR...
The iron need in pregnancy is significantly higher comparison to that the nonpregnant state. absorbed during used for expansion of maternal erythrocyte mass, fulfill fetus’s needs, create placenta, and cope with blood loss at delivery. Term neonates have a total body store about 1 g iron, all derived from mother. Despite overall increase nutritional requirements, biochemical, metabolic, physiological adjustments organism happen order meet extra demands support homeostasis iron. In healthy...
To investigate the association between periconceptional maternal dietary pattern and first-trimester embryonic growth.This was a prospective cohort study of 228 women with singleton ongoing pregnancy, which 135 were strictly dated spontaneous pregnancies 93 achieved after in-vitro fertilization or intracytoplasmatic sperm injection (IVF/ICSI). All underwent serial transvaginal three-dimensional ultrasound (3D-US) examinations from 6 + 0 to 13 weeks' gestation. Crown-rump length (CRL) volume...
HIV-1-affected couples' desire to have children and free sexual intercourses with the use of pre-exposure prophylaxis for negative partner has emerged as an alternative option assisted reproduction in aviremic patients under highly active antiretroviral therapy (HAART). It is already known that sperm quality may be impaired HIV-infected men. The underlying physiopathological mechanism still debated. aim this study was evaluate effects HAART on DNA fragmentation, comparing HIV-1-infected...
This study investigated the associations between maternal adherence to a healthy diet, first trimester placental markers, and pregnancy outcome. Singleton spontaneous pregnancies were enrolled at 11+0–13+6 gestational weeks in prospective cohort study. A nutritional score (0–10) measuring diet was calculated. transabdominal ultrasound scan for marker assessment performed (uterine artery (UtA) doppler, volume). Biochemical markers recorded (Pregnancy Associated Plasma Protein (PAPP-A), free...
Background HIV-1 infected patients show impaired semen parameters. Currently, it is not clear whether infection itself or antiretroviral therapy have an effect on We aim evaluate quality in a large cohort of fertile men under stable highly active (HAART) and to assess the HAART type duration Materials methods Between January 2010 June 2014, we enrolled retrospective case-control study 770 asking reproductive counselling with their HIV negative partner. Co-infections HBV HCV, genital tract...
Maternal obesity and gestational diabetes mellitus (GDM) are increasing worldwide, representing risk factors for both mother child short/long-term outcomes. Oxidative stress, lipotoxicity altered autophagy have already been reported in obesity, but few studies focused on obese pregnant women with GDM. Antioxidant macro/chaperone-mediated (CMA)-related gene expressions were evaluated herein GDM placentas. A total of 47 singleton pregnancies delivered by elective cesarean section enrolled: 16...
Maternal obesity has been associated with short- and long-term risks of pregnancy-perinatal adverse events, possibly due to alterations placental mitochondrial bioenergetics. However, several detrimental mechanisms occurring in the placentas women still need be clarified. Here, we analyzed features oxidative environment 46 pregnancies relation pre-pregnancy BMI. Seventeen Caucasian normal-weight (NW) twenty-nine who were obese (OB) enrolled. The protein expression CypD electron transfer...
<title>Abstract</title> <bold>Background: </bold>Assisted vaginal birth (AVB) refers to the obstetric procedure commonly performed during second stage of labor, aimed expedite delivery after evaluating alternatives options cesarean or expectant management. <bold>Objective</bold>: To evaluate risk factors for assisted births and compare perinatal outcomes vacuum extraction applied at mid/low cavity perineum. <bold>Study design</bold>: Retrospective observational monocentric study conducted on...