Karthik Ananth Mani

ORCID: 0000-0003-2038-856X
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Research Areas
  • Pickering emulsions and particle stabilization
  • Entomopathogenic Microorganisms in Pest Control
  • Nematode management and characterization studies
  • Surface Modification and Superhydrophobicity
  • Crystallography and molecular interactions
  • Cannabis and Cannabinoid Research
  • Polymer Surface Interaction Studies
  • Insect Resistance and Genetics
  • Protein Interaction Studies and Fluorescence Analysis
  • Plant tissue culture and regeneration
  • Advanced Polymer Synthesis and Characterization
  • Legume Nitrogen Fixing Symbiosis
  • X-ray Diffraction in Crystallography
  • Advanced Nanomaterials in Catalysis
  • Crystallization and Solubility Studies
  • Drug Transport and Resistance Mechanisms
  • Synthesis and biological activity
  • Insect Pest Control Strategies
  • Transgenic Plants and Applications
  • Plant Virus Research Studies
  • Gold and Silver Nanoparticles Synthesis and Applications
  • Biosensors and Analytical Detection
  • Crystal structures of chemical compounds
  • Adsorption and Cooling Systems
  • Advanced Fluorescence Microscopy Techniques

Hebrew University of Jerusalem
2021-2025

Agricultural Research Organization
2018-2025

SVS Medical College
2021

CIC energiGUNE
2016

Abstract Cannabis sativa is widely used for medical purposes and has anti-inflammatory activity. This study intended to examine the activity of cannabis on immune response markers associated with coronavirus disease 2019 (COVID-19) inflammation. An extract fraction from C. Arbel strain (F CBD ) substantially reduced (dose dependently) interleukin (IL)-6 -8 levels in an alveolar epithelial (A549) cell line. F contained cannabidiol (CBD), cannabigerol (CBG) tetrahydrocannabivarin (THCV),...

10.1038/s41598-021-81049-2 article EN cc-by Scientific Reports 2021-01-14

Abstract This research presents gene expression after DNA delivery into intact plant cells by protein nanoparticles. The is carried out casein nanoparticles (CNPs). A plasmid harboring the red fluorescent DsRed sequence absorbed to CNPs surface electrostatic interaction and served as a model in this study, its monitored fluorescence of protein. zeta potential tuned altering pH obtain sufficient between for successful Nicotiana benthamiana . are covalently modified with green dye...

10.1002/adfm.202314756 article EN Advanced Functional Materials 2024-02-19

4-[(1Z)-1-(2-carbamothioylhydrazinylidene)ethyl]phenyl acetate [Ace semi],4-[(1Z)-1-(2-carbamothioylhydrazinylidene)ethyl]phenyl propanoate [Pro semi] from the family of thiosemicarbazones derivative has been newly synthesized. It good anticancer activity as well antibacterial and it is also less toxic in nature, its binding characteristics are therefore huge interest for understanding pharmacokinetic mechanism drug. The thiosemicarbazone to human serum albumin (HSA) investigated by studying...

10.1080/07391102.2015.1075905 article EN Journal of Biomolecular Structure and Dynamics 2015-09-14

This study presents antibiofilm coating formulations based on Pickering emulsion templating. The contains no bioactive material because its properties stem from passive mechanisms that derive solely the superhydrophobic nature of coating. Moreover, unlike most formulations, our system is fluorine-free, thus making method eminently suitable for food and medical applications. formulation water in toluene or xylene emulsions are stabilized using commercial hydrophobic silica, with...

10.1021/acsami.1c10125 article EN ACS Applied Materials & Interfaces 2021-08-02

A new approach for single cell microencapsulation in an oil-in-water (o/w) Pickering emulsion is presented. The water/paraffin emulsions were stabilized by amine-functionalized silica nanoparticles. droplet size of the was highly tunable, and ranged from 1 to 30 μm diameter. controllable along with high colloidal stability emulsionswas harnessed obtain microencapsulation. Successful encapsulation conidia entomopathogenic fungus Metarhizium brunneum studied confirmed via confocal laser...

10.1021/acsomega.8b02225 article EN publisher-specific-oa ACS Omega 2018-10-29

4-[3-acetyl-5-(acetylamino)-2,3-dihydro-1,3,4-thiadiazole-2-yl]phenyl benzoate from the family of thiadiazole derivative has been newly synthesized. It good anticancer activity as well antibacterial and less toxic in nature, its binding characteristics are therefore huge interest for understanding pharmacokinetic mechanism drug. The to human serum albumin (HSA) investigated by studying quenching mechanism, kinetics molecular distance, r between donor acceptor (thiadiazole derivative) was...

10.1080/07391102.2016.1162751 article EN Journal of Biomolecular Structure and Dynamics 2016-03-21

Growing global population and environmental concerns necessitate the transition from chemical to eco-friendly pest management. Entomopathogenic fungi (EPF) are rising candidates for this task due their ease of growing, broad host range unique disease process, allowing EPF infect hosts directly through its cuticle. However, EPF’s requirement high humidity negates integration into conventional agriculture. To mitigate problem, we formulated Metarhizium brunneum conidia in an oil-in-water...

10.3390/jof7070499 article EN cc-by Journal of Fungi 2021-06-23

This study presents a new eco-friendly formulation of entomopathogenic nematodes (EPNs) based on individual coating EPNs with titanium dioxide (TiO2) nanoparticles (NPs) and mineral oil via oil-in-water Pickering emulsions. Mineral emulsions stabilized by amine-functionalized (TiO2-NH2) particles were prepared. 40:60 50:50 oil-water volume ratios using 2 wt % TiO2-NH2 found to be the most stable droplet size suitable for further studied their toxicity against incorporated EPNs....

10.1021/acs.jafc.2c04424 article EN Journal of Agricultural and Food Chemistry 2022-10-13

Abstract The soil‐borne virus known as tomato brown rugose fruit (ToBRFV) has a low rate of around 3% soil‐mediated infection when the soil root debris from previous 30–50 day development cycle plants infected with ToBRFV. This study presents anti‐viral coating formulations based on Pickering emulsion. formulation is water‐in‐canola oil emulsions stabilized using commercial hydrophobic silica, water‐soluble polymer (sodium polyacrylic acid). structure and their stability were characterized...

10.1002/pat.6293 article EN Polymers for Advanced Technologies 2024-01-01

This study presents an individual encapsulation of fungal conidia in oil-in-water Pickering emulsion at a single-conidium yield 44%. The was characterized by analysis confocal microscopy micrographs. Mineral emulsions stabilized amine-functionalized titania dioxide (TiO 2 -NH or titania-NH ) particles were prepared. structure and the stability investigated different compositions LUMiSizer ® respectively. most stable with droplet size suitable for further studied their capabilities. yields...

10.3389/fchem.2021.726874 article EN cc-by Frontiers in Chemistry 2021-11-29

Tomato brown rugose fruit virus (ToBRFV) is a soil-borne showing low percentage of ca. 3% soil-mediated infection when the soil contains root debris from previous 30–50 day growth cycle ToBRFV-infected tomato plants. We designed stringent conditions ToBRFV by increasing length pre-growth to 90–120 days, adding inoculum as well truncating seedling roots, which increased susceptibility infection. These rigorous were employed challenge efficiency four innovative root-coating technologies in...

10.3390/v15030728 article EN cc-by Viruses 2023-03-11

DNA Delivery In article number 2314756, Guy Mechrez and co-workers present gene expression after delivery into intact plant cells by protein nanoparticles. The is carried out casein zeta potential of the CNPs tuned to obtain successful model Nicotiana benthamiana. Confocal fluorescence microscopy results show intracellular uptake also supported RT-PCR qRT-PCR.

10.1002/adfm.202470089 article EN mit Advanced Functional Materials 2024-04-01

Immobilizing particles on beads, fibers, or filaments, when only one side is exposed to the reaction medium and therefore can be selectively functionalized, a scalable easy control strategy for fabrication of amphiphilic Janus particles. Here we describe new, robust method based immobilization polymethylsilsesquioxane (PMSQ) polycarbonate (PC), high impact-resistance polymer with superior mechanical properties. The PC microspores performed via inverse solvent displacement method. PMSQ are...

10.3390/polym10080900 article EN Polymers 2018-08-10

Lung inflammation is associated with elevated pro-inflammatory cytokines and chemokines. Treatment FCBD:std (standard mix of cannabidiol [CBD], cannabigerol [CBG] tetrahydrocannabivarin [THCV]) leads to a marked reduction in the alveolar epithelial cells, but not macrophages. In present study, combined anti-inflammatory effect two corticosteroids (dexamethasone budesonide) non-steroidal drugs (NSAID; ibuprofen diclofenac), was examined. Enzyme-linked immunosorbent assay (ELISA) used...

10.3390/ph15121559 article EN cc-by Pharmaceuticals 2022-12-14

The asymmetric unit of the title compound, C17H17N3O2S, consists two independent mol-ecules, A and B, with different conformations: in mol-ecule A, dihedral angles between central benzene ring pendant tolyl carbamo-thio-ylhydrazono groups are 71.12 (9) 5.95 (8)°, respectively. corresponding B 50.56 (12) 26.43 (11)°, Both mol-ecules feature an intra-molecular N-H⋯N hydrogen bond, which closes S(5) ring. In crystal, linked by N-H⋯O, N-H⋯S C-H⋯O bonds, generating a three-dimensional network.

10.1107/s2056989014026942 article EN cc-by Acta Crystallographica Section E Crystallographic Communications 2014-12-12
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