Polyphenolic compounds present in tea, red wine, and chocolate form thin adherent polyphenol films on substrates through spontaneous adsorption from solution. From this observation emerged a versatile comprehensive approach to surface modification of variety solid, porous, nanoparticulate composed metals, ceramics, polymers (see picture; ROS=reactive oxygen species). Phenols polyphenols are widely distributed plant tissues, where they linked diverse biological functions such as chemical...

Interactions between polymer molecules and inorganic nanoparticles can play a dominant role in nanocomposite material mechanics, yet control of such interfacial interaction dynamics remains significant challenge particularly water. This study presents insights on how to engineer hydrogel mechanics via nanoparticle interface-controlled cross-link dynamics. Inspired by the adhesive chemistry mussel threads, we have incorporated iron oxide (Fe3O4 NPs) into catechol-modified network obtain...

Transient network hydrogels cross-linked through histidine–divalent cation coordination bonds were studied by conventional rheologic methods using histidine-modified star poly(ethylene glycol) (PEG) polymers. These materials inspired the mussel, which is thought to use histidine–metal impart self-healing properties in mussel byssal thread. Hydrogel viscoelastic mechanical as a function of metal, pH, concentration, and ionic strength. The equilibrium metal-binding constants determined dilute...

Substrate-independent coatings inspired by plant tannins were formed from diverse phenolic starting compounds.

Abstract The mechanical holdfast of the mussel, byssus, is processed at acidic pH yet functions alkaline pH. Byssi are enriched in Fe 3+ and catechol‐containing proteins, species with chemical interactions that vary widely over range byssal processing. Currently, link between pH, ‐catechol reactions, function poorly understood. Herein, it described how influences performance materials formed by reacting synthetic catechol polymers . Processing polymer through a mussel‐mimetic...

Abstract Most synthetic polymer hydrogel tissue adhesives and sealants swell considerably in physiologic conditions, which can result mechanical weakening adverse medical complications. This paper describes the synthesis characterization of mechanically tough zero‐ or negative‐swelling mussel‐inspired surgical based on catechol‐modified amphiphilic poly(propylene oxide)‐poly(ethylene oxide) block copolymers. The formation, swelling, bulk mechanical, adhesive properties resulting...

Polyphenolverbindungen, die in Tee, Rotwein und Schokolade vorkommen, bilden auf Trägermaterialien dünne haftende Polyphenolfilme durch spontane Adsorption aus einer Lösung. Auf der Grundlage dieser Beobachtung wurde ein allgemein anwendbarer Prozess zur Oberflächenmodifizierung von festen, porösen nanopartikulären Metall-, Keramik- Polymermaterialien entwickelt (siehe Bild; ROS=reaktive Sauerstoffspezies). Phenols and polyphenols are widely distributed plant tissues, where they linked to...

The mussel byssus is a remarkable attachment structure that formed by injection molding and rapid in-situ hardening of concentrated solutions proteins enriched in the catecholic amino acid 3,4-dihydroxy-L-phenylalanine (DOPA). Fe3+, found high concentrations byssus, has been speculated to participate redox reactions with DOPA lead protein polymerization, however direct evidence support this hypothesis lacking. Using small molecule catechols, DOPA-containing peptides, native foot proteins, we...

The facile design of polyester biomaterials has emerged as an important aspect polymer synthesis. As opposed to thermoplastics, thermosets are especially attractive for applications in the biomedical fields because they retain their geometry and experience a linear loss both mass mechanical properties during degradation. Herein, we report several based on photocurable prepolymers composed itaconic acid various polyols. Itaconic is renewable resource component known that demonstrated be...

Soft polyester elastomers have emerged as a promising family of biodegradable materials for drug delivery and tissue engineering. Specifically referring to soft engineering, potential biomaterials should be elastic flexible, so mimic the mechanical properties natural tissue. Herein, we report design several based on polycondensation erythritol, sugar substitute that is approved human consumption by Food Drug Administration, one eight dicarboxylic acids: glutaric, adipic, pimelic, suberic,...

We report the design of several elastomers based on thermal polycondensation α-ketoglutaric acid and one three triols: glycerol, 1,2,4-butanetriol, or 1,2,6-hexanetriol. By varying curing temperature duration process, a wide range mechanical properties was achieved. The values Young's modulus (0.1−657.4 MPa), ultimate stress (0.2−30.8 strain (22−583%) encompass many biological materials, increasing probability success for use poly(triol α-ketoglutarate) as biomaterial. Furthermore, series...

A straightforward, flexible, and inexpensive method to create patterned self-assembled monolayers (SAMs) on gold using microfluidics—microfluidic lithography—has been developed. Using a microfluidic cassette, alkanethiols were rapidly surfaces generate mixed monolayers. The patterning methodology is flexible and, by controlling the solvent conditions thiol concentration, permeation of into surrounding PDMS cassette can be advantageously used different feature sizes well-defined SAM surface...

A straightforward and versatile strategy for preparing a class of biodegradable amorphous polyketoesters is reported. series ketone-containing diesters diacids were combined with di(ethylene glycol) through condensation polymerization, achieving <Mn> values up to 10.1 x 10(3) g/mol. Glass transition temperatures ranged from -41 -6 degrees C, rendering all the materials liquid at room temperature. By including ketone groups in repeat unit, facile postpolymerization modifications possible by...

Cultural events: A methodology that combines surface chemistry with soft lithography and centrifugation allows the rapid, inexpensive, complete patterning of cells cell co-cultures (yellow red) on gold surfaces (green) covered by a self-assembled monolayer (blue). Sequential masking polydimethylsiloxane membrane (gray) controlled multiple lines (see picture).

Synthetic polyesters have become an integral part of various biomedical and engineering fields, such as tissue scaffolding therapeutic delivery. While polymer copolymers derived from lactide, glycolide, ε-caprolactone, p-dioxanone still dominate the industry, many new polymerization strategies materials are being explored, including thermal polycondensation. Adjusting curing conditions monomer feed ratios allows for easy control over macromolecular properties polymers resulting...

A straightforward, flexible, and inexpensive method to etch biodegradable poly(1,2,6-hexanetriol α-ketoglutarate) films is reported. Microfluidic delivery of the etchant, a solution NaOH, can create micron-scale channels through local hydrolysis polyester film. In addition, presence ketone in repeat unit allows for prior or post chemoselective modifications, enabling design functionalized microchannels. Delivery oxyamine tethered ligands react with groups on polyketoester generate covalent...

Novel biodegradable polymers enable chemoselective ligand immobilization. α-Ketoglutaric acid and tetra(ethylene glycol) were polymerized to generate a poly(ester ether) with ketone in the repeat unit. Treatment of this polymer oxyamine-containing ligands allowed selective introduction functionality. By capping each chain cross-linking groups, polyester can be molded by UV irradiation. After curing, films functionalized tune degradation rates act as noncytotoxic, biospecific ligand-mediated...

Thermal polyesterification has emerged as a successful method for synthesizing polyesters biomedical applications. However, to date, no general functionalization strategy been incorporated into materials designed by the thermal polycondensation of polyacids and polyols. Herein, we report design several elastomers based on 4-ketopimelic acid, citric one two diols: 1,6-hexanediol or 1,4-cyclohexanedimethanol. By varying diol curing conditions, were with range physical mechanical properties....

Abstract Pressure perturbation calorimetry quantifies the temperature dependence of a solute's thermal expansion coefficient, providing information about solute–solvent interactions. We tested idea that pressure can provide solvent‐accessible surface area by studying peptides with different secondary structures. The comprised two host–guest series: one predominately an α‐helix, other polyproline II helix. In aqueous buffer, we find correlation between amount structure as assessed circular...

Kulturereignisse: Mit einem Verfahren, das Oberflächenchemie mit Softlithographie und Zentrifugieren kombiniert, gelingt die rasche, günstige vollständige Bildung von Zellmustern gemischten Zellkulturen (gelb rot) auf Goldoberflächen (grün) selbstorganisierter Monoschicht (SAM; blau). Wiederholtes Maskieren der Oberfläche einer Polydimethylsiloxanmembran (grau) ermöglicht geordnete Abscheiden mehrerer Zell-Linien (siehe Bild).

Surface treatments of cellulose triacetate (CTA) films via atmospheric pressure plasmas containing helium and either O2 or C3F6 as plasma reactive gas were performed to study their effects on moisture barrier, transmittance, thermal, surface chemistry, morphological properties. Plasma treated CTA characterized using X-ray photoelectron spectroscopy (XPS), attenuated total reflectance-Fourier transform infrared spectroscopy, time-of-flight secondary ion mass spectrometry (ToF-SIMS),...

Surface topology has been shown to play a crucial role in the adhesive ability of gecko-inspired, embossed films. Herein, we report use Pattern Replication In Non-wetting Templates (PRINT) design micro- and nano-embossed films order explore relationship between surface chemistry, feature size, geometry, shear adhesion. Ketone-containing elastomers were synthesized from various amounts poly(ethylene glycol) diacrylate, 2-hydroxyethyl methacrylate, 2-(methacryloyloxy)ethyl acetoacetate. Due...