A5001022357- Neuroscience and Neural Engineering
- Advanced Sensor and Energy Harvesting Materials
- Conducting polymers and applications
- EEG and Brain-Computer Interfaces
- 3D Printing in Biomedical Research
- Muscle activation and electromyography studies
- Photoreceptor and optogenetics research
- Spinal Cord Injury Research
- Advanced Materials and Mechanics
- Transcranial Magnetic Stimulation Studies
- High voltage insulation and dielectric phenomena
- Psychedelics and Drug Studies
- Neurotransmitter Receptor Influence on Behavior
- Dielectric materials and actuators
- Advanced Memory and Neural Computing
- Neural dynamics and brain function
- Nanomaterials and Printing Technologies
- Neurological disorders and treatments
- Hydrogels: synthesis, properties, applications
- Heart Rate Variability and Autonomic Control
- Electrostatic Discharge in Electronics
- Nerve injury and regeneration
- Supramolecular Self-Assembly in Materials
- Electrowetting and Microfluidic Technologies
- Nicotinic Acetylcholine Receptors Study
Technische Universität Dresden
2019-2025
Leibniz Institute of Polymer Research
2021-2024
Central Institute of Mental Health
2024
University of Sheffield
2020-2023
Insigneo
2022
Center for Systems Biology Dresden
2019-2020
École Polytechnique Fédérale de Lausanne
2012-2016
Wyss Center for Bio and Neuroengineering
2016
University of Cambridge
2010-2013
Johannes Kepler University of Linz
2007-2011
The mechanical mismatch between soft neural tissues and stiff implants hinders the long-term performance of implantable neuroprostheses. Here, we designed fabricated with shape elasticity dura mater, protective membrane brain spinal cord. electronic which call e-dura, embeds interconnects, electrodes, chemotrodes that sustain millions stretch cycles, electrical stimulation pulses, chemical injections. These integrated modalities enable multiple neuroprosthetic applications. extracted...
A severe complication of spinal cord injury is loss bladder function (neurogenic bladder), which characterized by sensation and voluntary control micturition (urination), spontaneous hyperreflexive voiding against a closed sphincter (detrusor-sphincter dyssynergia). sacral anterior root stimulator at low frequency can drive volitional voiding, but surgical rhizotomy the lumbosacral dorsal roots needed to prevent dyssynergia. However, irreversible eliminates sexual function, gives no...
Abstract Synthetic conductive biopolymers have gained increasing interest in tissue engineering, as they can provide a chemically defined electroconductive and biomimetic microenvironment for cells. In addition to low cytotoxicity high biocompatibility, injectability adhesiveness are important many biomedical applications but proven be very challenging. Recent results show that fascinating material properties realized with bioinspired hybrid network, especially through the synergy between...
Abstract Electrically conductive materials that mimic physical and biological properties of tissues are urgently required for seamless brain–machine interfaces. Here, a multinetwork hydrogel combining electrical conductivity 26 S m −1 , stretchability 800%, tissue‐like elastic modulus 15 kPa with mimicry the extracellular matrix is reported. Engineering this unique set enabled by novel in‐scaffold polymerization approach. Colloidal hydrogels nanoclay Laponite employed as supports assembly...
Thin metal films coated on soft elastomeric foam substrates exhibit enhanced electromechanical performance. The open-cell structure conveys highly anisotropic mechanical properties within the top, thin capping elastomer at surface of foam. Upon stretching, large strain fields inducing cracks and folds localize above cells, while surrounding cell ligaments remain almost strain-free, enabling stable electrical conduction in metallic coating.
Hydrogels underpin many applications in tissue engineering, cell encapsulation, drug delivery and bioelectronics. Methods improving control over gelation mechanisms patterning are still needed. Here we explore a less-known approach relying on sequential electrochemical-chemical-chemical (ECC) reactions. An ionic species and/or molecule solution is oxidised conductive surface at specific electric potential. The oxidation generates an intermediate that reacts with macromolecule, forming...
Soft hydrogels have become an important class of materials for mimicking and interfacing biological soft tissues with potential applications in drug delivery, tissue engineering bioelectronics. Creative methods integrating other such as organic conductors are highly desired. Here, we describe the single-step electrosynthesis PEDOT/alginate into core-shell hybrid structures via electrochemical-chemical-chemical mechanism. Using a pulsed electropolymerisation protocol, generated PEDOT either...
Stretchable electronics (i.e., hybrid inorganic or organic circuits integrated on elastomeric substrates) rely elastic wiring. We present a technique for fabricating reversibly stretchable metallic films by printing silver-based ink onto microstructured silicone substrates. The wetting and pinning of the elastomer surface is adjusted optimized varying geometry micropillar arrays patterned substrate. resulting exhibit high electrical conductivity (∼11 000 S/cm) can stretch to 20% strain over...
In this paper we present a compliant neural interface designed to record bladder afferent activity. We developed the implant's microfabrication process using multiple layers of silicone rubber and thin metal so that gold microelectrode array is embedded within four parallel polydimethylsiloxane (PDMS) microchannels (5 mm long, 100 μm wide, deep). Electrode impedance at 1 kHz was optimized reactive ion etching (RIE) step, which increased porosity electrode surface. The electrodes did not...
We recently developed soft neural interfaces enabling the delivery of electrical and chemical stimulation to spinal cord. These stimulations restored locomotion in animal models paralysis. Soft can be placed either below or above dura mater. Theoretically, subdural location combines many advantages, including increased selectivity stimulation, lower thresholds, targeted through local drug delivery. However, these advantages have not been documented, nor their functional impact studied silico...
Platinum is electrochemically stable and biocompatible, remains the preferred material for fabrication of implantable neural electrodes. In a foil or film format, platinum mechanically stiff compared to interfaced biological tissue. We report soft, highly platinum-elastomer composite that offers both mechanical compliance electrochemical properties platinum. demonstrate high-performance novel mesocomposite printed on stretchable microelectrodes in vitro vivo. The new promising coating...
<title>Abstract</title> The impact of chronic alcohol consumption is evident in disruptions within prefrontal circuitries, resulting cognitive and behavioral deficits that underlie lost control over drinking. Given the limited efficacy current pharmacotherapy, we employed multifunctional bioelectronics to investigate potential direct electrical brain stimulation rectify neural impairments alcohol-dependent rats. Cortical counteracted observed deficiencies event-related potentials...
Neuroprostheses interfaced with transected peripheral nerves are technological routes to control robotic limbs as well convey sensory feedback patients suffering from traumatic neural injuries or degenerative diseases. To maximize the wealth of data obtained in recordings, interfacing devices required have intrafascicular resolution and provide high signal-to-noise ratio (SNR) recordings. In this paper, we focus on a possible building block three-dimensional regenerative implant:...
Abstract Direct Ink Writing is an additive fabrication technology that allows the integration of a diverse range functional materials into soft and bioinspired devices such as robots human‐machine interfaces. Typically, viscoelastic ink extruded from nozzle continuous filament circular cross section. Here it shown careful selection printing parameters height speed can produce filaments with cross‐sectional geometries. Thus, elliptic cylinder‐, ribbon‐, or groove‐shaped be printed. By using...
Abstract Patients with alcohol use disorder (AUD) who seek treatment show highly variable outcomes. A precision medicine approach biomarkers responsive to new treatments is warranted overcome this limitation. Promising relate prefrontal control mechanisms that are severely disturbed in AUD. This results reduced inhibitory of compulsive behavior and, eventually, relapse. We reasoned here dysfunction, which underlies vulnerability relapse, evidenced by altered neuroelectric signatures and...
We are reporting on the fabrication and electrical characterization of stretchable polydimethylsiloxane (PDMS) based microelectrode arrays for recording neuronal action potentials. Electrodes immersed in phosphate buffered saline solution. Their impedance spectra recorded as a function uniaxial macroscopic strain applied using custom built automated stretcher. propose model to account physical phenomena responsible conduction bulk electrode at metal–electrolyte interface. with active area...
Cellular polypropylene ferroelectrets are useful for broadband airborne ultrasound generation and detection up to the fundamental thickness extension resonance. The authors show that coupling of air alters electromechanical resonance foam. In an acoustical cavity, Fabry-Perot resonances obtained, which is in excellent agreement with plane wave model calculations. For material assessment applications, a figure merit used based on factor impedance material. good gases results from small
Abstract Bioelectronic interfaces employing arrays of sensors and bioactuators are promising tools for the study, repair engineering cardiac tissues. They typically constructed from rigid brittle materials processed in a cleanroom environment. An outstanding technological challenge is integration soft enabling closer match to mechanical properties biological cells Here we present an algorithm direct writing elastic membranes with embedded electrodes, optical waveguides microfluidics using...
When a peripheral nerve is injured after either trauma or neurodegenerative disease, motor function and sensory perception are impaired. Repair strategies aim both at reconstructing the damaged in promoting regeneration to enhance target reinnervation functional recovery. Advanced surgical procedures can enable efficient repair, but restoration of remains challenging. Among various factors influencing regeneration, electrical stimulation often cited as potential therapeutic approach engaging...