A5008119479- Hydrogels: synthesis, properties, applications
- Liver Disease Diagnosis and Treatment
- Pancreatic and Hepatic Oncology Research
- Medical Imaging Techniques and Applications
- Medical Imaging and Pathology Studies
- Renal and Vascular Pathologies
- MRI in cancer diagnosis
- Organ Donation and Transplantation
- Thyroid Disorders and Treatments
- Bone health and treatments
- 3D Printing in Biomedical Research
- Drug-Induced Hepatotoxicity and Protection
- Bone Tissue Engineering Materials
- Eicosanoids and Hypertension Pharmacology
- Thermal Regulation in Medicine
- Sarcoidosis and Beryllium Toxicity Research
- Global Cancer Incidence and Screening
- Bone health and osteoporosis research
- Biochemical Acid Research Studies
- Cancer Immunotherapy and Biomarkers
- Cancer, Hypoxia, and Metabolism
- Advanced Sensor and Energy Harvesting Materials
- Thyroid Cancer Diagnosis and Treatment
- Ophthalmology and Eye Disorders
- Pancreatitis Pathology and Treatment
University Hospital Carl Gustav Carus
2023-2025
National Center for Tumor Diseases
2023-2025
Helmholtz-Zentrum Dresden-Rossendorf
2019-2025
Deutschen Konsortium für Translationale Krebsforschung
2025
Technische Universität Dresden
2019-2024
Carl Gustav Carus-Institut
2024
German Cancer Research Center
2024
Heidelberg University
2024
Leipzig University
2018
Klinikum rechts der Isar
2005
Abstract Many features of extracellular matrices, e.g., self-healing, adhesiveness, viscoelasticity, and conductivity, are associated with the intricate networks composed many different covalent non-covalent chemical bonds. Whereas a reductionism approach would have limitation to fully recapitulate various biological properties simple structures, mimicking such sophisticated by incorporating functional groups in macromolecular system is synthetically challenging. Herein, we propose strategy...
Abstract Synthetic conductive biopolymers have gained increasing interest in tissue engineering, as they can provide a chemically defined electroconductive and biomimetic microenvironment for cells. In addition to low cytotoxicity high biocompatibility, injectability adhesiveness are important many biomedical applications but proven be very challenging. Recent results show that fascinating material properties realized with bioinspired hybrid network, especially through the synergy between...
Head and neck squamous cell carcinoma (HNSCC) is one of the most common tumor entities worldwide, with human papillomavirus (HPV) infection contributing to cancer development. Conventional therapies achieve only limited efficiency, especially in recurrent or metastatic HNSCC. As immune landscape decisively impacts survival patients treatment efficacy, this study comprehensively investigated immunological microenvironment (TME) its association patient outcome, special focus on several...
Diagnostic accuracy of CT in circumscript liver diseaseU Scherer, R Rothe, J Eisenburg, F Schildberg, P Meister and LissnerAudio Available | Share
Background/Objectives: Peripheral neuroblastic tumors (pNT) are a biologically heterogeneous group of embryonal that derive from the neural crest and affect sympathetic nervous system. So far, little is known about complex immune landscape in these rare childhood cancers. Methods: We focused on cell infiltrate treatment-naïve pNT 24 patients, including high-risk neuroblastoma (HR-NBL), non-high-risk (NHR-NBL), ganglioneuroblastoma (GNBL), ganglioneuroma (GN). To gain novel insights into...
The transamidase activity of transglutaminase 2 (TGase 2) is considered to be important for several pathophysiological processes including fibrotic and neoplastic tissue growth, whereas in healthy cells this enzymatic function predominantly latent. Methods that enable the highly sensitive detection TGase 2, such as application radiolabeled activity-based probes, will support exploration enzyme's various diseases. In context, radiosynthesis detailed vitro radiopharmacological evaluation an...
Abstract Hydrogel‐based injectable drug delivery systems provide temporally and spatially controlled release with reduced adverse effects on healthy tissues. Therefore, they represent a promising therapeutic option for unresectable solid tumor entities. In this study, peptide‐starPEG/hyaluronic acid‐based physical hydrogel is modified ferrocene to programmable orchestrated by matrix‐drug interaction local reactive oxygen species (ROS). The ROS‐responsive (hiROSponse) exhibits adequate...
Critical-size bone defects after compound fractures, infection, or tumor resection are challenging to treat. The same is true for fractures in patients with impaired healing due metabolic diseases and cancer. Despite considerable progress over the last decade surgical techniques, material design, dedicated imaging approaches, these scenarios represent unsolved clinical problems. high socioeconomic burden of such conditions justifies increasing interest novel osteoinductive drugs adjuvant...
The cyclin-dependent kinase 4 and 6 (CDK4/6) inhibitor palbociclib is an emerging cancer therapeutic that just recently gained Food Drug Administration approval for treatment of estrogen receptor (ER)-positive, human epidermal growth factor (Her)2-negative breast in combination with the ER degrader fulvestrant. However, CDK4/6 inhibitors are not cancer-specific may affect also other proliferating cells. Given importance T cells antitumor defense, we studied influence palbociclib/fulvestrant...
In this third in a series of reviews on adjuvant drug-assisted bone healing, further approaches aiming at influencing the healing process are discussed. Local and systemic modulation metabolism is pursued with use number drugs completely different indications, which characterized by pleiotropic spectrum action. These include used to treat lipid disorders (HMG-CoA reductase inhibitors), hypertension (ACE osteoporosis (bisphosphonates), cancer (proteasome inhibitors) others. Potential...
Abstract Stem cell bioengineering and therapy require different model systems materials in stages of development. If a chemically defined biomatrix system can fulfill most tasks, it minimize the discrepancy among various setups. By screening biomaterials synthesized through coacervation‐mediated self‐assembling mechanism, optimal for 2D human mesenchymal stromal (hMSC) culture osteogenesis is identified. Its utility hMSC further demonstrated coating porous bioactive glass scaffolds...
The treatment of critical-size bone defects following complicated fractures, infections or tumor resections is a major challenge. same applies to fractures in patients with impaired healing due systemic inflammatory and metabolic diseases. Despite considerable progress development establishment new surgical techniques, design graft substitutes imaging these scenarios still represent unresolved clinical problems. However, the active substances offers novel potential solutions for issues. This...