A5087494268- Cancer-related molecular mechanisms research
- Congenital heart defects research
- MicroRNA in disease regulation
- Circular RNAs in diseases
- RNA Research and Splicing
- RNA modifications and cancer
- Cardiomyopathy and Myosin Studies
- Endoplasmic Reticulum Stress and Disease
- Tissue Engineering and Regenerative Medicine
- Wind Turbine Control Systems
- Infectious Diseases and Tuberculosis
- Systemic Lupus Erythematosus Research
- RNA regulation and disease
- Cancer-related gene regulation
- Orthopedic Infections and Treatments
- Autophagy in Disease and Therapy
- Hydrogen embrittlement and corrosion behaviors in metals
- Mycobacterium research and diagnosis
- Peroxisome Proliferator-Activated Receptors
- Advanced battery technologies research
- Cardiac Ischemia and Reperfusion
- Plant and Fungal Interactions Research
- Inflammatory Myopathies and Dermatomyositis
- Heat shock proteins research
- Musculoskeletal pain and rehabilitation
Universidad de Jaén
2017-2024
Universidad de Extremadura
2021-2024
Fundación Medina
2024
University of California, San Diego
2024
Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán
1996-2024
To evaluate the safety and clinical efficacy of administering an anti-interleukin-10 (anti-IL-10) monoclonal antibody (mAb) to systemic lupus erythematosus (SLE) patients with active steroid-dependent disease. In addition, we sought assess effects in vivo IL-10 neutralization on biologic markers SLE.Treatment consisted 20 mg/day intravenous administration anti-IL-10 murine mAb (B-N10) for 21 consecutive days, a followup period 6 months. Six were studied.Treatment was safe well tolerated. All...
The human hippocampus and prefrontal cortex play critical roles in learning cognition
Oxidative stress, defined as the excess production of reactive oxygen species (ROS) relative to antioxidant defense, plays a significant role in development cardiovascular diseases. Endoplasmic reticulum (ER) stress has emerged an important source ROS and its modulation could be cardioprotective. Previously, we demonstrated that miR-16-5p is enriched plasma ischemic dilated cardiomyopathy (ICM) patients promotes ER stress-induced apoptosis cardiomyocytes vitro. Here, hypothesize might...
Drenkard, Cristina; Villa, Antonio R.; García-Padilla, Carlos; Pérez-Vázquez, María Esther; Alarcón-Segovia, Donato Author Information
Abstract Cardiovascular development is a complex developmental process in which multiple cell lineages are involved, namely the deployment of first and second heart fields. Beside contribution these cardiogenic fields, extracardiac inputs to developing provided by migrating cardiac neural crest cells proepicardial derived cells. The proepicardium (PE) transitory cauliflower-like structure located between hepatic primordia. PE constituted an internal mesenchymal component surrounded external...
PITX2 is a homeobox transcription factor involved in embryonic left/right signaling and more recently has been associated to cardiac arrhythmias. Genome wide association studies have pinpointed as major player underlying atrial fibrillation (AF). We previously described that expression impaired AF patients. Furthermore, distinct demonstrate Pitx2 insufficiency leads complex gene regulatory network remodeling, i.e. Wnt>microRNAs, leading ion channel impairment thus arrhythmogenic events mice....
Over the last decade we have witnessed an increasing number of studies revealing functional role non-coding RNAs in a multitude biological processes, including cellular homeostasis, proliferation and differentiation. Impaired expression can cause distinct pathological conditions, herein those affecting gastrointestinal cardiorespiratory systems, respectively. miR-15/miR-16/miR-195 family members been broadly implicated multiple regulation cell proliferation, apoptosis metabolism within...
Excess lipid accumulation in the heart is associated with lipotoxicity and cardiac dysfunction due to excessive fatty acid oxidation. Peroxisome proliferator-activated receptor gamma (PPARγ) modulates expression of key molecules involved FA metabolic pathway. Cardiomyocyte-specific overexpression PPARγ causes dilated cardiomyopathy mice. miR-130b-3p has been shown be downregulated plasma idiopathic patients, but its role modulating cardiomyocyte via remains unclear. Our objective was...
MicroRNAs have been explored in different organisms and are involved as molecular switches modulating cellular specification differentiation during the embryonic development, including cardiovascular system. In this study, we analyze expression profiles of microRNAs early cardiac development. By using whole mount situ hybridization developing chick embryos, with microRNA-specific LNA probes, carried out a detailed study miR-23b, miR-130a, miR-106a, miR-100 stages embryogenesis (HH3 to HH17)....
It is well known that multiple microRNAs play crucial roles in cardiovascular development, including miR-133a. Additionally, retinoic acid regulates atrial marker expression. In order to analyse the role of miR-133a as a modulator signalling during posterior segment heart tube formation, we performed functional experiments with and by means microinjections into cardiac precursors both primitive endocardial tubes chick embryos. Subsequently, subjected embryos whole mount situ hybridisation,...
Introduction Robust evidence exists regarding initiation, intensification or modification of treatments. Recommendations to de-escalate therapy are lacking, specifically in diabetes. A successful treatment de-intensification reduces overtreatment, polypharmacy, and risk adverse effects. Objective To encompass current recommendations for deprescribing common drugs create a consensus among health professionals. Methods We reviewed four databases approaches published between 2010–2022. Articles...
Dilated cardiomyopathy (DCM) encompasses various acquired or genetic diseases sharing a common phenotype. The understanding of pathogenetic mechanisms and the determination functional effects each etiology may allow for tailoring different therapeutic strategies. MicroRNAs (miRNAs) have emerged as key regulators in cardiovascular diseases, including DCM. However, their specific roles DCM etiologies remain elusive. Here, we applied mRNA-seq miRNA-seq to identify gene miRNA signature from...
Transcriptional regulation constitutes a key step in gene expression regulation. Myocyte enhancer factor 2C (MEF2C) is transcription of the MADS box family involved early development several cell types, including muscle cells. Over last decade, novel layer complexity modulating has emerged as non-coding RNAs have been identified, impacting both transcriptional and post-transcriptional microRNAs represent most studied abundantly expressed subtype small RNAs, their functional roles widely...
A large diversity of epigenetic factors, such as microRNAs and histones modifications, are known to be capable regulating gene expression without altering DNA sequence itself. In particular, miR-1 is considered the first essential microRNA in cardiac development. this study, potential role early chamber differentiation was analyzed through specific signaling pathways. For this, we performed chick embryos functional experiments by means microinjections into posterior precursors-of both...
Bmp and Fgf signaling are widely involved in multiple aspects of embryonic development. More recently non coding RNAs, such as microRNAs have also been reported to play essential roles during We previously demonstrated that microRNAs, i.e., miR-130, an role modulating early stages cardiomyogenesis. recently, we capable cell fate decision proepicardial/septum transversum (PE/ST) development, since over-expression miR-23 blocked while miR-125, miR-146, miR-223 miR-195 enhanced PE/ST-derived...