A5101674315- Nitric Oxide and Endothelin Effects
- Redox biology and oxidative stress
- Neurogenesis and neuroplasticity mechanisms
- Neuroinflammation and Neurodegeneration Mechanisms
- Adenosine and Purinergic Signaling
- Microplastics and Plastic Pollution
- Neurological Disease Mechanisms and Treatments
- Neonatal and fetal brain pathology
- Tryptophan and brain disorders
- Bone Tumor Diagnosis and Treatments
- Environmental Toxicology and Ecotoxicology
- Marine Biology and Environmental Chemistry
- Cystic Fibrosis Research Advances
- S100 Proteins and Annexins
- Neuroscience and Neuropharmacology Research
- Management of metastatic bone disease
- Phosphodiesterase function and regulation
- Sarcoma Diagnosis and Treatment
- Electron Spin Resonance Studies
- Mitochondrial Function and Pathology
- Histone Deacetylase Inhibitors Research
Hospitais da Universidade de Coimbra
2023
Instituto Politécnico da Guarda
2023
University of Algarve
2014-2020
Algarve Biomedical Center
2015-2020
University of Coimbra
2014-2020
Institute for Biotechnology and Bioengineering
2014
Centro de Neurociências e Biologia Celular
2012
Institute of Cell Biology and Neurobiology
2012
Universidade do Porto
2010
Neuroinflammation is characterized by activation of microglial cells, followed production nitric oxide (NO), which may have different outcomes on neurogenesis, favoring or inhibiting this process. In the present study, we investigated how inflammatory mediator NO can affect proliferation neural stem cells (NSCs), and explored possible mechanisms underlying effect. We are involved in regulation NSC following treatment with an stimulus (lipopolysaccharide plus IFN-γ), using a culture system...
The involvement of nitric oxide (NO) and cyclic GMP (cGMP) in neurogenesis has been progressively unmasked over the last decade. Phosphodiesterase 5 (PDE5) specifically degrades cGMP is highly abundant mammalian brain. Inhibition hydrolysis by blocking PDE5 a possible strategy to enhance first step neurogenesis, proliferation neural stem cells (NSC). In this work, we have studied effect on cell 3 inhibitors with different selectivity potency for PDE5, T0156, sildenafil, zaprinast, using...
Nitric oxide (NO) is an important inflammatory mediator involved in the initial boost proliferation of neural stem cells following brain injury. However, mechanisms underlying proliferative effect NO are still unclear. The aim this work was to investigate whether cyclic GMP (cGMP) and cGMP-dependent kinase (PKG) triggered by cells. For purpose, cultures isolated from mouse subventricular zone (SVZ) were used. We observed that long-term exposure donor (24 h), NOC-18, increased SVZ a manner,...
Hippocampal neurogenesis is changed by brain injury. When neuroinflammation accompanies injury, activation of resident microglial cells promotes the release inflammatory cytokines and reactive oxygen/nitrogen species like nitric oxide (NO). In these conditions, NO proliferation neural stem (NSC) in hippocampus. However, little known about role survival differentiation newborn injured dentate gyrus. Here we investigated following seizures regulation proliferation, migration, differentiation,...
Nitric oxide (NO) is involved in the upregulation of endogenous neurogenesis subventricular zone and hippocampus after injury. One main neurogenic pathways activated by NO extracellular signal-regulated kinase (ERK)/mitogen-activated protein (MAPK) pathway, downstream epidermal growth factor receptor. However, mechanism which stimulates cell proliferation through activation ERK/MAPK pathway remains unknown, although p21Ras seems to be one earliest targets NO. Here, we aimed at studying...
Nitric oxide (NO) is well established as a regulator of neurogenesis. NO increases the proliferation neural stem cells (NSC), and essential for hippocampal injury-induced neurogenesis following an excitotoxic lesion. One mechanisms underlying non-classical cell signaling protein S-nitrosylation. This post-translational modification consists in formation nitrosothiol group (R-SNO) cysteine residues, which can promote other oxidative modifications those residues. S-nitrosylation regulate many...
Ewing sarcoma (ES) is primarily recognized as a primary bone tumor; however, its extraosseous variant exceptionally rare and presents unique clinical challenges. In this article, we report the case of 22-year-old male who initially presented with abdominal swelling. Diagnostic tests included imaging CT scan, revealing solid liver mass. A thorough evaluation confirmed it to be an ES, supported by biopsy immunohistochemistry demonstrating positive expression for AE1/AE3 CD-99, along genetic...