A5030818649- Adenosine and Purinergic Signaling
- Tryptophan and brain disorders
- Exercise and Physiological Responses
- Child Nutrition and Feeding Issues
- Bipolar Disorder and Treatment
- Adipose Tissue and Metabolism
- Cerebral Palsy and Movement Disorders
- Genetics and Neurodevelopmental Disorders
- Thyroid Disorders and Treatments
- Coffee research and impacts
- Cholinesterase and Neurodegenerative Diseases
- Stress Responses and Cortisol
- Neuroscience and Neuropharmacology Research
- Antioxidant Activity and Oxidative Stress
- Growth Hormone and Insulin-like Growth Factors
- Neuroendocrine regulation and behavior
- Pancreatic function and diabetes
- Nerve injury and regeneration
- Cardiovascular and exercise physiology
- Biochemical Acid Research Studies
- Muscle metabolism and nutrition
- Eating Disorders and Behaviors
- Coenzyme Q10 studies and effects
- Platelet Disorders and Treatments
- Fibromyalgia and Chronic Fatigue Syndrome Research
University of Coimbra
2016-2023
Centro Universitário Metodista IPA
2016-2022
Universidade Federal do Rio Grande do Sul
2005-2020
Methodist University
2020
Hospital de Clínicas de Porto Alegre
2016
Abstract Despite the characteristic etiologies and phenotypes, different brain disorders rely on common pathogenic events. Glutamate-induced neurotoxicity is a event shared by disorders. Another occurring in pathological conditions increase of extracellular ATP levels, which now recognized as danger harmful signal brain, heralded ability P2 receptors (P2Rs) to affect wide range Yet, how P2R contribute neurodegeneration remains poorly defined. For that purpose, we examined contribution P2Rs...
Depressive conditions precipitated by repeated stress are a major socio-economical burden in Western countries. Previous studies showed that ATP-P 2X7 receptors (P R) and adenosine A 2A (A antagonists attenuate behavioral modifications upon exposure to stress. Since it is unknown if these two purinergic modulation systems work independently, we now investigated putative interplay between P R R. Adult rats exposed restraint for 14 days displayed an anxious (thigmotaxis, elevated plus maze),...
Increased ATP release and its extracellular catabolism through CD73 (ecto-5′-nucleotidase) lead to the overactivation of adenosine A2A receptors (A2AR), which occurs in different brain disorders. A2AR blockade blunts mood memory dysfunction caused by repeated stress, but it is unknown if increased coupled CD73-mediated formation responsible for upon stress. This was now investigated adult rats subject stress 14 consecutive days. Frontocortical hippocampal synaptosomes from stressed displayed...
Extracellular ATP is a danger signal to the brain and contributes neurodegeneration in animal models of Alzheimer's disease through its extracellular catabolism by CD73 generate adenosine, bolstering activation adenosine A 2A receptors (A R).Convulsive activity leads increased release, with resulting morphological alterations being eliminated R blockade.However, it not known if upon convulsions there CD73-mediated coupling between release overactivation, causing neurodegeneration.We now show...
Parkinson's disease is a neurodegenerative disease. Oxidative stress, i.e., the imbalance between generation of reactive oxygen species and antioxidant defense capacity body, plays an important role in pathogenesis this Physical exercise can regulate oxidative stress. The purpose study was to analyze short- long-term effects aquatic program on stress levels patients with carried out during 1 month two sessions per week (1 hour/session). Blood samples were collected at four different time...
Epigenetic changes have been shown to be associated with both aging process and aging-related diseases. There is evidence regarding the benefits of physical activity on functionality, cognition, quality life institutionalized older adults, however, molecular mechanisms involved are not elucidated. The purpose this pilot study was investigate effects a multimodal exercise intervention functional outcomes, cognitive performance, (QOL), epigenetic markers brain-derived neurotrophic factor...
Abstract The influence of the thyroid hormones on normal function mammalian central nervous system depends brain region and developmental stage. Adenine nucleotides their products also affect function; ATP is an excitatory neurotransmitter, adenosine has inhibitory effects neurotransmission. Thus, this study aimed to evaluate hypothyroidism hydrolysis in hippocampal cortical synaptosomes blood serum rats during different phases development. Rats aged 60 420 days old were divided into three...
The study aimed to compare the basal plasma levels of inflammatory markers (MCP-1, IL-1ra and IL-1β) in Parkinson Disease group (PDG) with control healthy subjects (control group, CG), as well investigate acute chronic effects an aquatic physiotherapy program on these biomarkers PDG. Firstly, a rest blood sampling was taken from antecubital vein PD CG. After, individuals were submitted supervisioned during 1 month, twice week (60 min/session). In order evaluate intervention biomarkers,...
The effects of ATP, ADP, and adenosine in the processes platelet aggregation, vasodilatation, coronary flow have been known for many years. sequential hydrolysis ATP to by soluble nucleotidases constitutes main system rapid inactivation circulating adenine nucleotides. Thyroid disorders affect a number biological factors including levels different fractions. Then, we intend investigate if responsible AMP are affected variations thyroid hormone blood serum from adult rats. Hyperthyroidism was...
A growing body of evidence has suggested that the imbalance epigenetic markers and oxidative stress appears to be involved in pathophysiology progression stroke. Thus, strategies modulate these biomarkers might considered targets for neuroprotection novel therapeutic opportunities patients. Physical exercise been reported induce changes improve clinical outcomes different populations. However, little is on this post-stroke The purpose study was investigate effect a single session with...