A5101944219- Neurogenesis and neuroplasticity mechanisms
- Chemical Reactions and Isotopes
- Extracellular vesicles in disease
- Plant Micronutrient Interactions and Effects
- Adenosine and Purinergic Signaling
- Glioma Diagnosis and Treatment
- Neuroscience and Neuropharmacology Research
- Plant Stress Responses and Tolerance
- Boron Compounds in Chemistry
- Computational Drug Discovery Methods
- Heavy Metal Exposure and Toxicity
- ATP Synthase and ATPases Research
- Trace Elements in Health
- Science, Research, and Medicine
- Connexins and lens biology
- Regulation of Appetite and Obesity
- Vanadium and Halogenation Chemistry
- Innovative Energy Harvesting Technologies
- Congenital heart defects research
- DNA Repair Mechanisms
- Craniofacial Disorders and Treatments
- Chromatin Remodeling and Cancer
- Electroconvulsive Therapy Studies
- Lysosomal Storage Disorders Research
- Metal-Catalyzed Oxygenation Mechanisms
Hospital de Santo António
2023-2024
Université Paris Cité
2021-2024
Institut de Psychiatrie et Neurosciences de Paris
2021-2024
Institut des Maladies Génétiques Imagine
2021-2023
Inserm
2021-2023
University of Coimbra
2016-2022
Universidade do Porto
2016-2021
Rede de Química e Tecnologia
2018-2021
Centro Hospitalar do Porto
2021
Institut Curie
2019
Abstract Despite the characteristic etiologies and phenotypes, different brain disorders rely on common pathogenic events. Glutamate-induced neurotoxicity is a event shared by disorders. Another occurring in pathological conditions increase of extracellular ATP levels, which now recognized as danger harmful signal brain, heralded ability P2 receptors (P2Rs) to affect wide range Yet, how P2R contribute neurodegeneration remains poorly defined. For that purpose, we examined contribution P2Rs...
The molecular mechanisms underlying circuit re-wiring in the mature brain remains ill-defined. An eloquent example of adult remodelling is hippocampal mossy fiber (MF) sprouting found diseases such as temporal lobe epilepsy. determinants this retrograde remain unclear. This may involve signaling system(s) controlling axon specification/growth during neurodevelopment reactivated epileptogenesis. Since adenosine A2A receptors (A2AR) control formation/outgrowth and synapse stabilization...
Cortical interneurons born in the subpallium reach cortex through tangential migration, whereas pyramidal cells their final position by radial migration. Purinergic signaling via P2Y1 receptors controls migration of intermediate precursor from ventricular zone to subventricular zone. It was also reported that blockade A2A (A2AR) somatostatin+ interneurons. Here we found A2AR control cortical projection neurons. In A2AR-knockout (KO) mouse embryos or naïve exposed an antagonist, observed...
Bone repair is a specialized type of wound controlled by complex multi-factorial events. The nervous system recognized as one the key regulators bone mass, thereby suggesting role for neuronal pathways in homeostasis. However, context injury and repair, little known on interplay between bone. Here, we addressed neuropeptide Y (NPY) arm during initial stages encompassing inflammatory response ossification phases femoral-defect mouse model. Spatial temporal analysis transcriptional protein...
Reelin (RELN) is a secreted glycoprotein essential for cerebral cortex development. In humans, recessive RELN variants cause cortical and cerebellar malformations, while heterozygous were associated to epilepsy, autism mild abnormalities. However, their functional effects remain unknown. We identified inherited de novo missense in patients with neuronal migration disorders (NMDs) as diverse pachygyria polymicrogyria. investigated culture the developing mouse how different impacted function....
Iron (Fe) deficiency chlorosis (IDC) affects the growth of several crops, especially when growing in alkaline soils. The application synthetic Fe-chelates is one most commonly used strategies IDC amendment, despite their associated negative environmental impacts. In a previous work, Fe-chelate tris(3-hydroxy-1-(H)-2-methyl-4-pyridinonate) iron(III) [Fe(mpp)3 ] has shown great potential for alleviating soybean (Glycine max) early stages plant development under hydroponic conditions. Herein,...
Brain manganese (Mn) accumulation is a key feature in patients with acquired hepatocerebral degeneration (AHD). The role of trace elements other than Mn AHD needs to be clarified. In this study, using inductively coupled plasma mass spectrometry, we aimed evaluate blood levels before and after liver transplantation (LT). Trace element the group were also compared those healthy controls (blood donors, n = 51). Fifty-one included study (mean age: 59.2 ± 10.6 years; men: 72.5%). had higher Mn,...
Abstract Ligands of the 3‐hydroxy‐4‐pyridinone (3,4‐HPO) class were considered eligible to formulate new Fe fertilizers for Iron Deficiency Chlorosis (IDC). Soybean ( Glycine max L.) plants grown in hydroponic conditions and supplemented with Fe‐chelate [Fe(mpp) 3 ] significantly greener, had increased biomass, able translocate more iron from roots shoots than those an equal amount commercially available chelate [FeEDDHA]. To understand influence structure 3,4‐HPO ligand on role improve...
EPR/<sup>51</sup>V-NMR parallel studies of [VO(3,4-HPO)<sub>2</sub>] complexes in MOPS buffer and POPC liposome suspensions provide information regarding solvents for oral administration.
ABSTRACT RELN is a large secreted glycoprotein that acts at multiple steps of cerebral cortex development, including neuronal migration. Only recessive mutations the Reelin gene ( ) have been associated with human cortical malformations and none has functionally characterized. We identified novel missense in both compound de novo heterozygous patients exhibiting an array migration disorders (NMDs) as diverse pachygyria, polymicrogyria heterotopia. Most caused defective secretion vitro and,...
Wolfram syndrome (WFS) is a neurological and endocrinological degenerative disorder, also known as DIDMOAD (Diabetes Insipidus, early-onset Diabetes Mellitus, progressive Optic Atrophy, Deafness) syndrome. It an autosomal recessive mostly involving the 1 gene (WFS1). The phenotypic pleiomorphism, rarity, molecular complexity complicate follow-up of these patients.We aimed to describe clinical characteristics 11 patients with this disorder. We retrospectively analysed all WFS diagnosed...
A prevalencia de plagiocefalia postural posterior aumentou nas ultimas duas decadas, devido em grande parte a recomendacao da Academia Americana Pediatria (1992) para deitar os lactentes decubito dorsal, modo prevenir sindrome morte subita. Foram avaliadas as medidas antropometricas cranianas (com recurso um craniometro) duma populacao saudaveis, com o objectivo identificar a deformacoes posturais, presenca factores risco associados e evolucao clinica. Numa amostra 72 lactentes, encontrou-se...
<p>Effect of treatments in developing models.</p>
<p>Pharmacokinetics of Cy5.5-AsiDNA after IP injection.</p>
<p>Effect of treatments in developing models.</p>
<p>Pharmacokinetics of Cy5.5-AsiDNA after IP injection.</p>
SUMMARY Brain development requires correct tissue patterning and production of appropriate cell types. Transcription factors (TFs) play essential roles in these processes, regulating the expression target genes responsible for neuronal subtypes specific features. Cell adhesion molecules are key components identities that control sorting, migration, neurite outgrowth/guidance synaptogenesis. To date, link between TFs is considered to be unidirectional. Here, we demonstrate ectopic Dbx1 leads...