A5088777524- Adenosine and Purinergic Signaling
- Receptor Mechanisms and Signaling
- Neuroscience and Neuropharmacology Research
- Neurotransmitter Receptor Influence on Behavior
- Stress Responses and Cortisol
- Pharmacological Receptor Mechanisms and Effects
- Tryptophan and brain disorders
- Adipose Tissue and Metabolism
- Coffee research and impacts
- Neuropeptides and Animal Physiology
- Treatment of Major Depression
- Neuroendocrine regulation and behavior
- Birth, Development, and Health
- Sleep and Wakefulness Research
- Ion channel regulation and function
- Cognitive Abilities and Testing
- Eating Disorders and Behaviors
- Circadian rhythm and melatonin
- Genetics, Aging, and Longevity in Model Organisms
- Memory and Neural Mechanisms
- Cancer, Stress, Anesthesia, and Immune Response
- Cannabis and Cannabinoid Research
- Mind wandering and attention
- Peptidase Inhibition and Analysis
- Diet and metabolism studies
Inserm
2011-2024
Université Paris-Est Créteil
2020-2024
Institut Mondor de Recherche Biomédicale
2019-2024
Fondation FondaMental
2020
Centre National de la Recherche Scientifique
2005-2018
Centre de Recherche en Neurosciences de Lyon
2009-2016
Université Claude Bernard Lyon 1
2010-2015
Université de Rouen Normandie
1997-2015
Centre Hospitalier Le Vinatier
2009
Rockefeller University
2006
The pathophysiology of depression remains enigmatic, although abnormalities in serotonin signaling have been implicated. We found that the 1B receptor [5-hydroxytryptamine (5-HT1B) receptor] interacts with p11. p11 increases localization 5-HT1B receptors at cell surface. is increased rodent brains by antidepressants or electroconvulsive therapy, but decreased an animal model and brain tissue from depressed patients. Overexpression function cells recapitulates certain behaviors seen after...
The locomotor stimulatory effects induced by caffeine (1,3,7‐trimethylxanthine) in rodents have been attributed to antagonism of adenosine A 1 and 2A receptors. Little is known about its depressant seen when acutely administered at high doses. roles receptors these activities were investigated using a Digiscan actimeter experiments carried out mice. Besides caffeine, the antagonist SCH 58261 (5‐amino‐7‐(β‐phenylethyl)‐2‐(8‐furyl)pyrazolo[4,3‐e]‐1,2,4‐triazolo[1,5‐c]pyrimidine), DPCPX...
Depression is a multifactorial illness and genetic factors play role in its etiology. The understanding of physiopathology relies on the availability experimental models potentially mimicking disease. Here we describe model built up by selective breeding mice with strikingly different responses tail suspension test, stress paradigm aimed at screening potential antidepressants. Indeed, “helpless” are essentially immobile as well Porsolt forced-swim they show reduced consumption palatable 2%...
Current antidepressant treatments are inadequate for many individuals, and when they effective, require several weeks of administration before a therapeutic effect can be observed. Improving the treatment depression is challenging. Recently, two-pore domain potassium channel TREK-1 has been identified as new target in depression, its antagonists might become effective antidepressants. In mice, deletion gene results depression-resistant phenotype that mimics treatments. Here, we validate mice...
Adenosine, an ubiquitous neuromodulator, and its analogues have been shown to produce ‘depressant’ effects in animal models believed be relevant depressive disorders, while adenosine receptor antagonists found reverse adenosine‐mediated effect. We designed studies assess whether A 2A antagonists, or genetic inactivation of the would effective established screening procedures, such as tail suspension forced swim tests, which are predictive clinical antidepressant activity. Adenosine knockout...
Significance Stress can increase susceptibility to developing psychiatric disorders, including depression. Understanding the neurobiological mechanisms underlying stress resilience and is key identifying novel targets for development of more effective treatments stress-related disorders. Here we show that specific isoforms GABA B receptor subunits differentially regulate resilience. Specifically, B(1a) −/− mice are susceptible whereas B(1b) resilient stress-induced anhedonia psychosocial...
Adenosine and its analogues have been shown to induce "behavioral despair" in animal models believed be relevant depression. Recent data that selective adenosine A2A receptor antagonists (e.g., SCH 58261, ZM241385, KW6002) or genetic inactivation of the was effective reversing signs behavioral despair tail suspension forced swim tests, two screening procedures predictive antidepressant activity. were active test using either mice previously screened for having high immobility scores...
: There is growing evidence suggesting that antagonists of group II metabotropic glutamate receptors (mGluR2/3) exhibit antidepressant-like properties in several preclinical models depression. However, all those studies have been performed using competitive non-selective orthosteric antagonists. In this study we extensively characterized a selective negative allosteric modulator (4-[3-(2,6-Dimethylpyridin-4-yl)phenyl]-7-methyl-8-trifluoromethyl-1,3-dihydrobenzo[b][1,4]diazepin-2-one, namely...
Although numerous studies investigated the mechanisms underlying 3,4-methylenedioxymethamphetamine (MDMA)-induced neurotoxicity, little is known about its long-term functional consequences on 5-HT neurotransmission in mice. This led us to evaluate delayed effects of MDMA exposure system, using in-vitro and in-vivo approaches both 5-HTT wild-type knock-out Acute application slices dorsal raphe nucleus (DRN) induced concentration-dependent release cell firing inhibition. Four weeks after...
Abstract The selective A 2A receptor antagonist [ 3 H]SCH 58261 was injected intravenously in mice and the radioactivity accumulating various brain regions determined by tissue sampling. Radioactivity levels of interest such as striatum were highest 15 min after injection quickly declined thereafter (30 1 h postinjection) a time‐dependent manner. amount labelling ranked follows: (4.6 ± 0.3 fmol/mg protein) >> cortex > hippocampus pons = hypothalamus cerebellum (0.5 0.05 protein)....
Catalepsy assessed using the bar test was measured in both adenosine A2A receptor knockout (A2AR KO) and wild-type WT) mice submitted to acute administration of dopamine D2 antagonist haloperidol (0.5, 2, 4, 6 mg/kg i.p.), D1 SCH 23390 (0.3–3 mg/kg, s.c.), vesicular monoamine transporter blocker reserpine (3–5 s.c.) or acetylcholine muscarinic agonist pilocarpine (25–50 i.p.). Except for reserpine, catalepsy scores were significantly lower A2AR KO than WT following low doses these...