A5028956153- Cancer Immunotherapy and Biomarkers
- Immunotherapy and Immune Responses
- Dermatology and Skin Diseases
- Cutaneous Melanoma Detection and Management
- Cutaneous lymphoproliferative disorders research
- Medicine and Dermatology Studies History
- Cancer Genomics and Diagnostics
- CAR-T cell therapy research
- Lymphoma Diagnosis and Treatment
- Hair Growth and Disorders
- Immune Cell Function and Interaction
- Ocular Oncology and Treatments
- Melanoma and MAPK Pathways
- Dermatological diseases and infestations
- Immune cells in cancer
- Dermatologic Treatments and Research
- Autoimmune Bullous Skin Diseases
- S100 Proteins and Annexins
- Allergic Rhinitis and Sensitization
- Nail Diseases and Treatments
- Cancer Diagnosis and Treatment
- Nonmelanoma Skin Cancer Studies
- Poxvirus research and outbreaks
- Ferroptosis and cancer prognosis
- Brain Metastases and Treatment
University Medical Center Hamburg-Eppendorf
2021-2025
Universität Hamburg
2021-2025
University Cancer Center Hamburg
2022-2024
Klinik und Poliklinik für Neurologie
2023-2024
Eppendorf (Germany)
2023
Martini-Klinik
2022
Highlights•Drugs currently used against irAEs reduce anti-tumor immunity•ECP induces adiponectin production in inflamed organs while sparing tumor tissue•ECP high response rates patients with ICI-induced irAEsSummaryImmune-related adverse events (irAEs) cancer receiving immune checkpoint inhibitors (ICIs) cause morbidity and necessitate cessation of treatment. Comparing irAE treatments, we find that immunity is preserved mice after extracorporeal photopheresis (ECP) but reduced...
The role of Sentinel Lymph Node Biopsy (SLNB) is pivotal in the contemporary staging cutaneous melanoma. In this review, we examine advanced molecular testing platforms like gene expression profiling (GEP) and immunohistochemistry (IHC) as tools for predicting prognosis sentinel lymph nodes. We compare these innovative approaches with traditional assessments. Additionally, delve into shared genetic protein markers between GEP IHC tests their relevance to melanoma biology, exploring...
Circulating tumor cells (CTCs) play an important role in metastasis formation. Aberrant signaling of oncogenic pathways (e.g., PI3K/AKT/mTOR pathway) drives progression. In this work, the susceptibility colon cancer CTC-derived cell line CTC-MCC-41 to AKT and mammalian target rapamycin (mTOR) inhibitors was evaluated. Additionally, functional expressed isoforms characterized line. The efficacy inhibitor MK2206, mTOR RAD001, combination examined a murine intracardiac xenotransplantation...
Immune checkpoint inhibition has revolutionized melanoma therapy, but many patients show primary or secondary resistance. Biomarkers are, therefore, urgently required to predict response prior the initiation of therapy and monitor disease progression. In this prospective study, we analyzed serum C-C motif chemokine ligand 20 (CCL20) concentration using an enzyme-linked immunosorbent assay. Blood was obtained at baseline before immunotherapy with anti-PD-1 monotherapy Nivolumab Ipilimumab in...
Abstract Background The treatment of melanoma has been revolutionized by the use immune checkpoint inhibition (ICI), but many patients do not benefit. Furthermore, immune‐related adverse events may occur during therapy. A predictive biomarker is needed to reliably identify benefitting. In lung, renal cell and bladder cancer early C‐reactive protein (CRP) kinetics were shown be a for ICI. Objective Here, we investigate CRP as ICI in patients. Methods Two independent prospectively collected...
Summary Background Interferon‐alpha is an important therapeutic option for the treatment of cutaneous T‐cell lymphomas (CTCL). Since approved recombinant interferon‐α‐2a (IFN‐α2a) has no longer been produced since January 2020, pegylated interferon‐α2a (pegIFN‐α2a) can be used as alternative treatment, even though it not CTCL. The aim this multicentre study was to generate comprehensive data on efficacy and tolerability pegIFN‐α2a in Patients Methods A multicenter retrospective conducted...
Uveal Melanoma (UM) is a rare disease; however, it the most common primary intraocular malignant tumor in adults. Hematogenous metastasis, occurring up to 50% of cases, mainly liver (90%), associated with poor clinical course and treatment failure. In contrast dramatic benefits immunotherapy many entities, as seen cutaneous melanoma, immune checkpoint inhibitors (ICI) do not achieve comparable results Metastatic UM (MUM). The aim this study was investigate whether combination ICI...
Background:There is a high demand for dermatological care in Germany. As use of teledermatology has increased significantly, this study aimed to investigate the impact on patient care. Methods:This retrospective cross-sectional used data from direct-to-consumer platform using store-and-forward technology available Germany between July 2021 and April 2022. Additional characteristics were collected voluntary follow-up questionnaire, 28 days after teleconsultation. Results:Data 1,999 enrolled...
Oral finasteride and topical minoxidil are the current standard of care for male androgenetic alopecia a combination two treatments can be considered greater efficacy. Clinical trials have also yielded promising results, but routine data lacking.
Abstract Background Adjuvant treatment of stage II–IV melanoma with PD‐1‐based immune checkpoint inhibitors (ICI) has improved relapse‐free survival (RFS) and therefore become a standard‐of‐care option. Approximately 25%–30% patients still recur within 1 year. Predictive biomarkers reflecting real‐world data are desired. The predictive relevance tumour tissue PD‐L1 expression in the adjuvant setting remains inconclusive. Objectives This retrospective, observational study was conducted to...
Immune checkpoint inhibition (ICI) has yielded remarkable results in prolonging survival of metastatic melanoma patients but only a subset individuals treated respond to therapy. Success ICI treatment appears depend on the number tumor-infiltrating effector T-cells, which are known be influenced by activated eosinophils. To verify co-occurrence eosinophils and T-cells melanoma, immunofluorescence was performed 285 primary or tumor tissue specimens from 118 patients. Moreover, eosinophil...
The number of online prescription platforms (OPPs) offering telemedical diagnosis and treatment, including finasteride, for androgenetic alopecia (AA) by using medical questionnaires (MQs) has increased. This type care delivery differs completely from traditional forms. study aimed to investigate a potential paradigm shift in AA treatment measuring the extent traffic generated OPPs that exclusively treat furthermore characterizing sociodemographic features men undergoing finasteride an OPP...
Background: Adherence to dermatological treatment is described as poor. Empathy and open communication in the physician–patient relationship has been proven improve adherence. As direct-to-consumer teledermatology enables patients access consultations without in-person interactions, we hypothesized adherence be low. Methods: The objective of study was examine teledermatology. This retrospective cross-sectional used data from treated through a German platform between July 2021 April 2022....
Summary Background and Objectives Skin diseases are a common reason for consultations in pediatric practice. The present study aims to characterize the dermatological requests of resident specialists using teledermatology Germany. Patients Methods This analysis consultation requests, submitted by pediatricians designated dermatologist via telemedical system ( PädExpert) store‐and‐forward technology, was performed between February 2021 December 2021. Results included 504 requests. mean age...