A5038344083- Forensic Entomology and Diptera Studies
- Insect behavior and control techniques
- Diptera species taxonomy and behavior
- Insect and Pesticide Research
- Forensic and Genetic Research
- Animal testing and alternatives
- Yersinia bacterium, plague, ectoparasites research
- Molecular Biology Techniques and Applications
- Identification and Quantification in Food
- HIV Research and Treatment
- Neuroblastoma Research and Treatments
- Forensic Anthropology and Bioarchaeology Studies
- Animal Ecology and Behavior Studies
- Bacillus and Francisella bacterial research
- Entomological Studies and Ecology
- Genomics and Phylogenetic Studies
- HIV/AIDS drug development and treatment
- Immune Cell Function and Interaction
- Geophysical and Geoelectrical Methods
- Genetic Neurodegenerative Diseases
- Cancer-related Molecular Pathways
- Marine Toxins and Detection Methods
- Drug Transport and Resistance Mechanisms
- Environmental DNA in Biodiversity Studies
- Paleopathology and ancient diseases
Goethe University Frankfurt
2014-2024
University Hospital Frankfurt
2015-2024
Senckenberg Biodiversity and Climate Research Centre
2013
Correct species identification of blow flies is a crucial step for understanding their biology, which can be used not only designing fly control programs, but also to determine the minimum time since death. Identification techniques are usually based on morphological and molecular characters. However, use classical morphology requires experienced entomologists correct identification; while rely sound laboratory expertise remain ambiguous certain taxa. Landmark-based geometric morphometric...
Abstract Flubendazole was shown to exert anti-leukaemia and anti-myeloma activity through inhibition of microtubule function. Here, flubendazole tested for its effects on the viability in total 461 cancer cell lines. Neuroblastoma identified as highly flubendazole-sensitive entity a screen 321 lines from 26 entities. also reduced five primary neuroblastoma samples nanomolar concentrations thought be achievable humans inhibited vessel formation tumour growth chick chorioallantoic membrane...
This study highlights the importance of insect evidence by evaluating 949 insect-associated cases, including 139 entomological reports, from 2001 to 2019 at Institute Legal Medicine Frankfurt/Germany. With a high number cases in summer months and low colder season, 78.5% bodies were found indoors, regardless year or month. In more than 80% where PMI information was available (n = 704), presumed ranged 1 21 days, period during which can provide day-specific estimate PMImin. insects have been...
Estimation of the postmortem interval in advanced stages is a challenging task. Although there are several approaches available for addressing changes (human) body or its environment (ecologically and/or biochemically), most restricted to specific timeframes individual and environmental conditions. It well known, instance, that buried bodies decompose remarkably different manner than on ground surface. However, data how established methods PMI estimation perform under these conditions...
Aurora kinase inhibitors displayed activity in pre-clinical neuroblastoma models. Here, we studied the effects of pan-aurora inhibitor tozasertib (VX680, MK-0457) and aurora alisertib (MLN8237) that shows some specificity for A over B a panel cell lines with acquired drug resistance. Both compounds anti-neuroblastoma nanomolar range. The mechanism included inhibition signalling as indicated by decreased phosphorylation substrate histone H3, cycle G2/M phase, induction apoptosis. but not was...
The bluebottle blow fly Calliphora vicina is a common species distributed throughout Europe that can play an important role as forensic evidence in crime investigations. Developmental rates of C. from distinct populations Germany and England were compared under different temperature regimes to explore the use growth data geographical regions for local case work. Wing morphometrics molecular analysis between these also studied indicators biological differences. One colony each German English...
In homicides with entomological evidence, it may be important to prove the presumed association of fly larvae a corpse, especially if is in doubt whether all maggots used for expertise developed and fed on it. The present study demonstrates first time possibility analyzing human microsatellite DNA digestive tract necrophagous that decomposed bodies postmortem interval up four months. obtained STR profiles support maggot specific corpse. addition, identification host species (e.g., animal...
Novel treatment options are needed for the successful therapy of patients with high-risk neuroblastoma. Here, we investigated cyclin-dependent kinase (CDK) inhibitor SNS-032 in a panel 109 neuroblastoma cell lines consisting 19 parental and 90 sublines acquired resistance to 14 different anticancer drugs. Seventy-three percent all four primary tumor samples displayed concentrations that reduce viability by 50% range therapeutic plasma levels reported (<754 nM). Sixty-two two 90% this...