A5082906602- Hearing Loss and Rehabilitation
- Hearing, Cochlea, Tinnitus, Genetics
- Ear Surgery and Otitis Media
- Noise Effects and Management
- Facial Nerve Paralysis Treatment and Research
- Medical Practices and Rehabilitation
- Neurogenesis and neuroplasticity mechanisms
- Speech and Audio Processing
- Radiation Dose and Imaging
- Vestibular and auditory disorders
- Mesenchymal stem cell research
- Nasal Surgery and Airway Studies
- Ultrasound in Clinical Applications
- Hearing Impairment and Communication
- Cancer Cells and Metastasis
- Meningioma and schwannoma management
- Voice and Speech Disorders
- Medical Imaging Techniques and Applications
- Acoustic Wave Phenomena Research
- Advanced Sensor and Energy Harvesting Materials
- Ear and Head Tumors
- Esophageal and GI Pathology
- Tracheal and airway disorders
- Advanced X-ray and CT Imaging
- Foreign Body Medical Cases
University of Würzburg
2015-2025
Universitätsklinikum Würzburg
2016-2025
Klinik und Poliklinik für Hals-, Nasen-, Ohrenheilkunde
2015-2025
Comprehensive Cancer Center Mainfranken
2013-2024
Medical University of Vienna
2023
Textron Systems (United Kingdom)
2023
Nike (United States)
2023
Google (United States)
2022
Klinik und Poliklinik für Hals-Nasen-Ohren-Heilkunde
2018
Smith College
2018
<b><i>Background:</i></b> While hearing aids for a contralateral routing of signals (CROS-HA) and bone conduction devices have been the traditional treatment single-sided deafness (SSD) asymmetric loss (AHL), in recent years, cochlear implants (CIs) increasingly become viable choice, particularly countries where regulatory approval reimbursement schemes are place. Part reason this shift is that CI only device capable restoring bilateral input to auditory system hence...
Seed amplification assays (SAA) are becoming commonly used in synucleinopathies to detect α-synuclein aggregates. Studies Parkinson's disease (PD) and isolated REM-sleep behavior disorder (iRBD) have shown a considerably lower sensitivity the olfactory epithelium than CSF or skin. To get an insight into (α-syn) distribution within nervous system reasons for low sensitivity, we compared SAA assessment of nasal brushings skin biopsies PD (n = 27) iRBD patients 18) unaffected controls 30)....
Objectives To describe a technique for the intraoperative monitoring of residual hearing during cochlear implant (CI) procedure and, thus, to identify time occurrence and surgical steps leading loss. Study Design Prospective audiologic analysis in patient series. Setting Tertiary referral center. Subjects Patients with subjected implantation. Interventions During implantation, microphonics (CMs) response frequency-specific stimuli were recorded patients hearing. Thresholds determined before...
Fitting cochlear implant (CI) users can be challenging. Anatomy-based fitting (ABF) maps may have the potential to lead better objective and subjective outcomes than conventional clinically based (CBF) methods. ABF were created via information derived from exact electrode contact positions, which determined post-operative high-resolution flat panel volume computer tomography clinical software. The outcome measures speech understanding in quiet noise self-perceived sound quality with CBF map...
To evaluate a new methodological approach of applying anatomy-based fitting (ABF) in experienced cochlear implant (CI) users.Three unilateral and bilateral CI users with postlingual hearing loss.Postoperative imaging, via high-volume Dyna computed tomography, exact electrode measurement positions were integrated into the clinical software following procedure, which adapted individual frequency bandwidths within audio processor.Speech perception quiet noise, mapping, self-perceived level...
To examine the long-term results of an active middle-ear implant (AMEI) with floating-mass transducer (FMT) technology.Prospective cohort study German-speaking patients implanted AMEI between 2006 and 2013.Single-center study.Eighty-three patients.AMEI FMT technology implantation.Long-term outcome (27 mo; range, 12-84 mo) for position in correlation pure-tone audiometry, auditory thresholds frequency-modulated (warble) tones, vibroplasty pure speech audiometry quiet noise.In 15.6% patients,...
Human mesenchymal stem cells (hMSC) are frequently used in tissue engineering. Due to their strong tumor tropism, hMSC seem be a promising vehicle for anticancer drugs. However, interactions between and cancer ambiguous. Particularly the cytokines growth factors play an important role progression metastasis. The present study evaluated effects of on head neck squamous cell carcinoma (HNSCC) lines (FaDu HLaC78) vitro. released several factors. FaDu HLaC78 showed significant enhancement...
Spinal muscular atrophy with respiratory distress type 1 is a neuromuscular disorder characterized by progressive weakness and of the diaphragm skeletal muscles, leading to death in childhood. No effective treatment available. The degeneration (Nmd(2J)) mouse shares crucial mutation immunoglobulin mu-binding protein 2 gene (Ighmbp2) spinal patients also displays some basic features human disease. This model serves as promising tool understanding complex mechanisms disease exploring novel...
Introduction Active middle-ear implants with floating-mass transducer (FMT) technology are used to treat mild-to-severe sensorineural hearing losses. The standard surgical approach for incus vibroplasty is a mastoidectomy and posterior tympanotomy, crimping the FMT long process. An alternative fixation side less trauma might be short process body. aim of this study was develop test coupling device its functional properties in temporal bone preparations clinical practice. Materials Methods...
AbstractObjectives In cochlear implantation, preoperative prediction of electrode position has recently gained increasing attention. Currently, planning is usually done by multislice CT (MSCT). However, flat-panel volume (fpVCT) and its secondary reconstructions (fpVCTSECO) allow for more precise visualization the cochlea. Combined with a newly developed otological software, every single contact can be effectively predicted. this study it was investigated how accurately radiological...
The Vibrant Soundbridge active middle ear implant is indicated for the treatment of different types hearing loss. Recently, a novel system determining performance based on auditory brainstem response (ABR) was developed. A reference value expected ABR thresholds determined base substantial number measurements in this work. ABRs were recorded patients following VSB surgery. standard employed, utilizing an implemented optimized chirp stimulus, which transmitted directly to via AcoustiAP...
Zusammenfassung Hintergrund Die Studie untersucht die inverse Nutzung des Floating Mass Transducer (FMT) der Vibrant Soundbridge® (Fa. MED-EL, Innsbruck, Österreich) als Mikrofon in einem Modellversuch. Sollte dies anwendbar sein, ergäben sich interessante Anwendungsmöglichkeiten z. B. eines vollimplantierbaren Cochleaimplantats. Material und Methoden Durch experimentelle Messungen an Trommelfell-Gehörgangs-Modell wurden akustischen Eigenschaften FMT bei Verwendung Mikrofon, einschließlich...
Acute heart failure (AHF) is a life-threatening condition and common cause of hospitalization. The defining clinical feature AHF volume overload, leading to pulmonary peripheral edema consequently weight gain. Vocal biomarkers have the potential facilitate early detection worsening HF prevention episodes by offering non-invasive, low-barrier monitoring tool. AHF-Voice study prospective monocentric cohort designed investigate trajectories voice alterations during after AHF, identify vocal...
Introduction In cochlear implantation (CI), precise preoperative duct length (CDL) and angular insertion depth (AID) measurements are pivotal for individualized electrode carrier selection, since recipients benefit from sufficient coverage of the carrier, enabling electric stimulation all crucial frequency bands. Since quality temporal bone CT largely depends on acquisition reconstruction settings is limited by technical capabilities scanner, this study aims to assess how radiation dose...
This study investigates the inverse use of Vibrant Soundbridge® Floating Mass Transducer (FMT; MED-EL, Innsbruck, Austria) as a microphone in pilot test. Should this be applicable, it would open up interesting application possibilities, e.g., for fully implantable cochlear implant. Experimental measurements on an ear canal-eardrum model were used to analyze acoustic properties FMT when microphone, including frequency response and sensitivity. The from Direct Drive Simulation Set was coupled...
Objective To determine the optimal coupling efficiency by auditory brainstem response (ABR) in patients with aural atresia undergoing vibroplasty to ensure sound transmission and minimize need for revision surgery. Study design Retrospective data analysis. Setting Tertiary referral center an established active middle ear implant program. Patients 14 ears of 13 congenital malformation receiving Interventions Therapeutic surgical treatment hearing rehabilitation human subjects. Main Outcome...
To describe a technique enabling the intraoperative assessment of mechanical coupling active middle ear implants in patients with normal or dysfunctional ears.Patients sensorineural mixed hearing loss subjected to revision surgery an implant.Recording compound action potentials (CAPs) auditory nerve response stimulation via implant during surgery.CAP thresholds as measure and system integrity.Determining CAP may be suitable for identifying proper ear, even if ossicular chain is disrupted.
Zusammenfassung Die Nutzung mobiler Informations- und Kommunikationstechnologie im Kontext medizinscher gesundheitsnaher Dienstleistungen, z. B. in Form von Apps, gewinnt, leider jedoch häufig unter Missachtung notwendiger Qualitätskriterien, immer mehr an Bedeutung. So erscheint es wichtig, dass neben einer die Anwendungssoftware kontrollierenden Instanz möglichst hoch qualifizierte Akteure des Gesundheitswesens bei der Erstellung mitwirken. Schon aus Haftungsgründen muss beratende Arzt...
The inferior colliculus (IC) is a nucleus of the auditory pathway and its fourth relay station. It integrates afferent information from superior olivary complex cochlear nucleus. To date, no causal therapeutic options are known for damaged neuronal structures in this area. Regenerative medicine offers potential approach to causally treating hearing impairment. After neural stem cells had been identified certain areas pathway, question arouses, whether IC also has neurogenic potential. Cells...
For the classification of facial paresis, various systems description and evaluation in form clinician-graded or software-based scoring are available. They serve purpose scientific clinical assessment spontaneous course disease monitoring therapeutic interventions. Nevertheless, none have been able to achieve universal acceptance everyday practice. Hence, a quick precise tool for assessing functional status nerve would be desirable. In this context, possibilities that TrueDepth camera recent...