A5009635561- Functional Brain Connectivity Studies
- Advanced Neuroimaging Techniques and Applications
- Advanced MRI Techniques and Applications
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Child and Adolescent Psychosocial and Emotional Development
- Death Anxiety and Social Exclusion
- Bullying, Victimization, and Aggression
- Schizophrenia research and treatment
- Neuroscience and Neuropharmacology Research
- Perfectionism, Procrastination, Anxiety Studies
- Olfactory and Sensory Function Studies
- Behavioral Health and Interventions
- Neuroendocrine regulation and behavior
- Biochemical Analysis and Sensing Techniques
- Infrared Thermography in Medicine
- Advanced Chemical Sensor Technologies
- Neurotransmitter Receptor Influence on Behavior
- Suicide and Self-Harm Studies
- Dementia and Cognitive Impairment Research
- Regulation of Appetite and Obesity
- Stress Responses and Cortisol
- Mental Health Research Topics
- Retinoids in leukemia and cellular processes
- Neuroscience of respiration and sleep
- Media Influence and Health
Temple University
2019-2023
Temple College
2021
University of Pennsylvania
2014-2019
Stony Brook University
2018
California University of Pennsylvania
2017
Philadelphia University
2016
Background: Measurements of olfaction may serve as useful biomarkers incipient dementia. Here we examine the improvement in diagnostic accuracy Alzheimer's disease (AD) and mild cognitive impairment (MCI) when assessing both functioning odor identification. Objective: To determi ne utility identification a supplementary screening test AD. Methods: Sniffin' Sticks Odor Identification Test (SS-OIT) Montreal Cognitive Assessment (MoCA) were administered 262 AD, 174 MCI [150 amnestic (aMCI), 24...
Structural brain abnormalities have been amply demonstrated in schizophrenia. These include volume decrements the perirhinal/entorhinal regions of ventromedial temporal lobe, which comprise primary olfactory cortex. Olfactory impairments, are a hallmark schizophrenia, precede onset illness, distinguish adolescents experiencing prodromal symptoms from healthy youths, and may predict transition prodrome to frank psychosis. We therefore examined lobe regional volumes large adolescent sample...
Background: The transition from mild cognitive impairment (MCI) to Alzheimer's disease is characterized by a decline in performance many domains. Cognitive profiles MCI are heterogeneous, however, and additional insights into markers of incipient dementia needed. Typ ically, studies focus on average or mean performance, but ignore consistency across WIV (within-individual variability) provides an index this potential marker decline. Objective: To use neurocognitive data the Disease...
Emerging evidence indicates the cerebellum contributes to cognitive functions including social reward processing, yet its specific role relative established regions like ventral striatum remains undefined. We hypothesized would respond equivalently both positive and negative rewards. This prediction is grounded in classical findings that operates via supervised learning mechanisms rely on error signals rather than traditional reward-based reinforcement. Using fMRI, we examined adolescents...
Anxiety and depression often emerge in adolescence. A normative increase the desire for peer acceptance may be one of many contributing factors. These shifts occur during a phase development which neural reward networks, including structures such as ventral striatum, undergo critical changes. Despite salience feedback adolescence, responses to have largely been examined monetary domain, leaving open questions about social rewards. Moreover, most paradigms do not tease apart different aspects...
Background Violence exacts staggering personal and financial costs – a burden disproportionally born by adolescents young adults. This may be partially due to an increased sensitivity social rejection during this critical phase of development. Irritability, transdiagnostic symptom, is often elicited interactions. Yet, little known about age differences in rejection‐elicited aggression irritability. Progress toward testing such relations has been hindered lack ecologically‐valid tasks that...
Perturbations in dopamine system function may increase risk of substance use disorder (SUD). We recently demonstrated that neuromelanin (NM) MRI signal the substantia nigra, a non-invasive index function, is elevated long term cocaine users (Cassidy et al., 2020). However, it unclear whether NM-MRI linked to SUD, or byproduct long-term drug use. Our prior work failed show relations between and functional engagement ventral striatum during monetary reward task. social experiences are commonly...
Memory is a reconstructive process that can result in events being recalled as more positive or negative than they actually were. While recall biases may contribute to well-being, promote internalizing symptoms, such social anxiety. Adolescence characterized by increased salience of peers and peak incidence Symptoms often wax wane before becoming intractable during adulthood. Open questions remain regarding how when for feedback are expressed individual differences anxiety across...
ABSTRACT Data quality is increasingly recognized as one of the most important confounding factors in brain imaging research. It particularly for studies development, where age systematically related to in-scanner motion and data quality. Prior work has demonstrated that head biases estimates structural neuroimaging measures. However, objective measures are not available images. Here we sought identify quantitative T1-weighted volumes, describe how such relate cortical thickness, delineate...
Adolescent males and females differ in their responses to social threat. Yet, threat processing is often probed non-social contexts using the error-related negativity (ERN; Flanker EEG Task), which does not yield sex-specific outcomes. fMRI studies show inconsistent patterns of neural engagement during processing. Thus, relation between across sexes effects perceived level on brain function are unclear. We tested interactive effect threat-vigilance (ERN), sex (N = 69; Male=34;...
Memory is a reconstructive process that can result in events being recalled as more positive or negative than they actually were. While recall biases may contribute to well-being, promote internalizing symptoms, such social anxiety. Adolescence characterized by increased salience of peers and peak incidence Symptoms often wax wane before becoming intractable during adulthood. Open questions remain regarding how when for feedback are expressed, individual differences anxiety across...
The human brain is organized into large-scale functional modules that have been shown to evolve in childhood and adolescence. However, it remains unknown whether structural networks are similarly refined during development, potentially allowing for improvements executive function. In a sample of 882 participants (ages 8-22) who underwent diffusion imaging as part the Philadelphia Neurodevelopmental Cohort, we demonstrate network become more segregated with age, weaker connections between...