A5091977560- Cancer Immunotherapy and Biomarkers
- Cancer Research and Treatments
- CRISPR and Genetic Engineering
- Phagocytosis and Immune Regulation
- interferon and immune responses
- Immune Cell Function and Interaction
- Extracellular vesicles in disease
- Gut microbiota and health
- Immune cells in cancer
- Cell death mechanisms and regulation
- Click Chemistry and Applications
- Clinical Nutrition and Gastroenterology
Technical University of Munich
2023-2025
Inter-individual differences in response to immune checkpoint inhibitors (ICI) remain a major challenge cancer treatment. The composition of the gut microbiome has been associated with differential ICI outcome, but underlying molecular mechanisms unclear, and therapeutic modulation challenging.
Tumor-derived extracellular vesicles (EVs) have been associated with immune evasion and tumor progression. We show that the RNA-sensing receptor RIG-I within cells governs biogenesis immunomodulatory function of EVs. Cancer-intrinsic activation releases EVs, which mediate dendritic cell maturation T antitumor immunity, synergizing checkpoint blockade. Intact RIG-I, autocrine interferon signaling, GTPase Rab27a in are required for immunostimulatory Active intrinsic signaling composition EV...
Changes in the intestinal microbiome and microbiota-derived metabolites predict clinical outcomes after allogeneic hematopoietic stem cell transplantation (allo-HSCT). Here, we report that desaminotyrosine (DAT), a product of bacterial flavonoid metabolism, correlates with improved overall survival reduced relapse rates allo-HSCT patients. In preclinical mouse models, treatment synthetic DAT prevents graft-versus-host disease by protecting barrier promoting regeneration contributes to...
Background Immune checkpoint inhibitors (ICIs) of programmed cell death protein-1 (PD-1) or cytotoxic T-lymphocytes-associated protein 4 (CTLA-4) reinvigorate strong polyclonal T-cell immune responses against tumor cells. For many patients, these therapies fail because the development spontaneous is often compromised, as microenvironment (TME) lacks proinflammatory signals resulting in suboptimal activation antigen-presenting cells (APCs). Necroptosis a special form associated with leakage...
Summary Intestinal stem cells (ISC) promote tissue repair after genotoxic or immune-mediated injury. However, ISCs are particularly sensitive to various stressors and primary targets of overwhelming immune responses such as interferon-γ (IFNγ)-mediated killing. In mouse models gut damage biopsies from patients having undergone allo-hematopoietic cell transplantation, we observed IFNy expression by intestinal T reg cells. leverage combined IFNγ interleukin 10 (IL-10) stimulation nurture the...
Background: Inter-individual differences in response to immune checkpoint inhibitors (ICI) remain a major challenge cancer treatment. The composition of the gut microbiome has been associated with differential ICI outcome, but underlying molecular mechanisms unclear, and therapeutic modulation challenging.Methods: We established an vivo model treat mice type‑I interferon (IFN-I)-modulating, bacterial-derived metabolite desaminotyrosine (DAT) order improve therapy. Broad spectrum antibiotics...