A5076708058- Renal Diseases and Glomerulopathies
- Renal Transplantation Outcomes and Treatments
- COVID-19 Clinical Research Studies
- Complement system in diseases
- COVID-19 and healthcare impacts
- Pregnancy and Medication Impact
- SARS-CoV-2 and COVID-19 Research
- Long-Term Effects of COVID-19
- COVID-19 Impact on Reproduction
- Pediatric Urology and Nephrology Studies
- Vasculitis and related conditions
- Organ Donation and Transplantation
- Renal and Vascular Pathologies
- Mesenchymal stem cell research
- Receptor Mechanisms and Signaling
- Cell Adhesion Molecules Research
- Acute Kidney Injury Research
- Organ Transplantation Techniques and Outcomes
- Chronic Kidney Disease and Diabetes
- Iron Metabolism and Disorders
- Tissue Engineering and Regenerative Medicine
- Cardiac Fibrosis and Remodeling
- Wound Healing and Treatments
- Infectious Encephalopathies and Encephalitis
- Neurological Complications and Syndromes
Friedrich-Alexander-Universität Erlangen-Nürnberg
2020-2025
Universitätsklinikum Erlangen
2020-2025
Medical University of Graz
2020
Most patients who became critically ill following infection with COVID-19 develop severe acute respiratory syndrome (SARS) attributed to a maladaptive or inadequate immune response. The complement system is an important component of the innate that involved in opsonization viruses but also triggering further cell responses. Complement activation was seen plasma adsorber material clogged during treatment COVID-19. Apart from lung, kidney second most common organ affected by Using...
Abstract Background Uromodulin (UMOD) is expressed in kidneys and mainly excreted the urine, although a smaller amount also released into serum. Here, we investigated UMOD acute kidney injury (AKI), with particular focus on utility of serum as marker for nephron loss. Methods Blood samples were collected 6 h, 24 3 days 8 weeks after ischemia/reperfusion (I/R) rat model. To investigate impact number levels, sera tissue from healthy, uninephrectomized (Unx) 5/6-nephrectomized (Snx) rats...
Severe acute respiratory syndrome corona virus 2 (SARS-CoV-2) preferentially affects epithelia of the upper and lower tract. Thus, impairment kidney function has been primarily attributed until now to secondary effects such as cytokine release or fluid balance disturbances. We provide evidence that SARS-CoV-2 can directly infiltrate a allograft. A 69-year-old male, who underwent pancreas-kidney transplantation 13 years previously, presented our hospital with coronavirus disease 2019...
Mesenchymal stem/stromal cells (MSCs) exert beneficial effects during wound healing, and cell-seeded scaffolds are a promising method of application. Here, we compared the suitability clinically used collagen/elastin scaffold (Matriderm) with an electrospun Poly(ε-caprolactone)/poly(l-lactide) (PCL/PLA) as carriers for human amnion-derived MSCs (hAMSCs). We created epidermal-like PCL/PLA evaluated its microstructural, mechanical, functional properties. Sequential spinning different...
Background: In the past, elevated blood pressure was considered an exclusion criterion for living kidney donation because of concerns about premature failure. Hypertension leads to complement deposits and renal fibrosis in kidney. Therefore, aim this study investigate whether increased can be observed grafts hypertensive compared normotensive donors. Methods: Zero-time biopsies from 238 donors (52 hypertensive) corresponding one-year protocol were examined C1q, C3c, MASP-2. Findings patients...
Changes in the intestinal microbiome and microbiota-derived metabolites predict clinical outcomes after allogeneic hematopoietic stem cell transplantation (allo-HSCT). Here, we report that desaminotyrosine (DAT), a product of bacterial flavonoid metabolism, correlates with improved overall survival reduced relapse rates allo-HSCT patients. In preclinical mouse models, treatment synthetic DAT prevents graft-versus-host disease by protecting barrier promoting regeneration contributes to...
Abstract SARS-CoV-2 is characterized by a multiorgan tropism including the kidneys. Recent autopsy series indicated that can infect both tubular and glomerular cells. Whereas cell infiltration may contribute to acute kidney injury, data on potential clinical correlative affection rare. We describe first case of nephrotic syndrome in context COVID-19 renal transplant recipient. A 35 year old male patient received allograft for primary focal segmental glomerulosclerosis (FSGS). Three months...
Abstract In renal transplantation, complement is involved in ischemia reperfusion injury, graft rejection and dysfunction. However, it still unclear how induction of its activation are initiated. Using allograft biopsies a well-characterized cohort 28 transplant patients with no (Ctrl), delayed function (DGF), acute T-cell-mediated (TCMR) or antibody-mediated (ABMR) we analyzed differences reaction. For that mRNA was isolated from FFPE sections, quantified multiplex gene expression panel...
Die Komplementkaskade umfasst eine Vielzahl von löslichen und gebundenen Proteinen ist ein wichtiger Bestandteil des angeborenen Immunsystems. Wenn die Kaskade durch einen der drei Aktivierungswege angestoßen wird, produziert das Komplementsystem rasch große Mengen Proteinfragmenten, potente Mediatoren entzündlicher, vasoaktiver metabolischer Reaktionen sind. Alle münden in terminale mit Bildung Membranangriffskomplexes, Formung Membranporen Zellen lysiert. Obwohl für Abwehr Pathogenen...
Uncovering the function of understudied G protein-coupled receptors (GPCRs) provides a wealth untapped therapeutic potential. The poorly understood adhesion GPCR Gpr126 (Adgrg6) is widely expressed in developing kidneys. In adulthood, expression enriched parietal epithelial cells (PECs) and collecting duct urothelium. Whether plays role kidney disease remains unclear. Here, we characterized diseased kidneys mice, rats, humans. RT-PCR data show that altered disease. A quantitative RNAscope®...
Ischemia/reperfusion (I/R) is inevitable during kidney transplantation and causes acute injury (AKI), which affects immediate outcome leads to chronic changes such as fibrotic remodeling of the graft. We investigated pro-fibrotic signaling after I/R, focusing on complement component receptor C5a/C5aR1 macrophage/tubule crosstalk. Male Dark Agouti rats were subjected I/R their kidneys harvested 10 min, 6 h, 24 3 days, 5 days 8 weeks reperfusion. The development renal fibrosis was assessed by...
The quality of a renal transplant can influence the clinical course after transplantation. Glomerular immune reactivity in transplants has previously been described, focusing particularly on IgA, and shown to disappear most cases without affecting outcome. Here, we describe cohort time zero biopsies with regard glomerular implications for histomorphology follow-up. 204 Time were analyzed by immunohistochemistry reactivity. 1-year evaluated histomorphological changes, which, together...
Introduction: IgA nephropathy (IgAN) is the most common primary glomerulonephritis (GN) in western countries and Henoch-Schönlein purpura nephritis (HSPN) form of vasculitis childhood. Renal biopsy findings both nephropathies are often similar characterized by mesangioproliferative GN with mesangial or mesangiocapillary C3c deposits. Objectives: The aim this study was to investigate significance glomerular C4d-deposition as a discriminating factor between pediatric HSPN IgAN. Patients...
Zero-time biopsies are taken to determine the quality of donor organ at time transplantation. Histological analyses alone have so far not been able identify parameters that allow prediction subsequent rejection episodes or graft survival. This study investigated whether gene expression zero-time might support this prediction. Using a well-characterized cohort 26 from renal transplant patients include 4 living (LD) and 22 deceased (DD) later developed no (Ctrl, n = 7), delayed function (DGF,...
Abstract Background IgA nephropathy (IgAN) is the most common primary glomerulonephritis (GN) in western countries and Henoch-Schönlein purpura nephritis (HSPN) form of vasculitis childhood. Renal biopsy findings both nephropathies are often similar characterized by mesangioproliferative GN with mesangial or mesangiocapillary C3c deposits. Aim this study was to investigate significances glomerular C4d-deposition as discriminating factor between pediatric HSPN IgAN Methods We retrospectively...
Journal of the American Society Nephrology 33(11S):p 347-348, November 2022. | DOI: 10.1681/ASN.20223311S1347c
Journal of the American Society Nephrology 33(11S):p 329, November 2022. | DOI: 10.1681/ASN.20223311S1329b