A5045115181- Functional Brain Connectivity Studies
- Statistical Methods and Bayesian Inference
- Statistical Methods and Inference
- Neural dynamics and brain function
- Advanced Causal Inference Techniques
- Dementia and Cognitive Impairment Research
- Bayesian Methods and Mixture Models
- Children's Physical and Motor Development
- Memory and Neural Mechanisms
- Alzheimer's disease research and treatments
- Neuroscience and Neuropharmacology Research
- Obesity, Physical Activity, Diet
- Advanced Neuroimaging Techniques and Applications
- EEG and Brain-Computer Interfaces
- Nitric Oxide and Endothelin Effects
- Thyroid Disorders and Treatments
- Health, Environment, Cognitive Aging
- Body Composition Measurement Techniques
- Neural and Behavioral Psychology Studies
- Mitochondrial Function and Pathology
- Human Health and Disease
- Advanced MRI Techniques and Applications
- Physical Activity and Health
- Spectroscopy and Laser Applications
- Laser Design and Applications
Umeå University
2016-2025
University of Jyväskylä
2019-2020
Banking University
2020
Kharkiv National Medical University
2016
Taras Shevchenko National University of Kyiv
2015
There is marked variability in both onset and rate of episodic-memory decline aging. Structural magnetic resonance imaging studies have revealed that the extent age-related brain changes varies markedly across individuals. Past whether regional atrophy accounts for aging yielded inconclusive findings. Here we related 15-year episodic memory to 4-year cortical subcortical gray matter volume white-matter connectivity lesions. In addition, word fluency, fluid IQ (Block Design), processing speed...
Physical activity and exercise beneficially link to brain properties cognitive functions in older adults, but the findings concerning adolescents remain tentative. During adolescence, undergoes significant changes, which are especially pronounced white matter. Studies provide contradictory evidence regarding influence of physical or aerobic-exercise on executive youth. Little is also known about between both fitness with brain's matter during puberty. We investigated connection aerobic 59...
Healthy aging is accompanied by progressive decline in cognitive performance and concomitant changes brain structure functional architecture. Age-accompanied alterations function have been characterized on a network level as weaker connections within networks along with stronger interactions between networks. This phenomenon has described age-related differences segregation. It suggested that related to associative processes are particularly sensitive deterioration segregation, possibly...
Concomitant exploration of structural, functional, and neurochemical brain mechanisms underlying age-related cognitive decline is crucial in promoting healthy aging. Here, we present the DopamiNe, Age, connectoMe, Cognition (DyNAMiC) project, a multimodal, prospective 5-year longitudinal study spanning adult human lifespan. DyNAMiC examines changes brain's structural functional connectome relation to dopamine D1 receptor availability (D1DR), their associations decline. Critically, due...
Introduction The apolipoprotein E (APOE) ε4 allele is the main genetic risk factor for Alzheimer's disease (AD), accelerated cognitive aging, and hippocampal atrophy, but its influence on association between hippocampus atrophy episodic-memory decline in non-demented individuals remains unclear. Methods We analyzed longitudinal (two to six observations) magnetic resonance imaging (MRI)–derived volumes episodic memory from 748 (55 90 years at baseline, 50% female) European Lifebrain...
ABSTRACT Motivated by the Swedish Betula study, we consider joint modeling of longitudinal memory assessments and hazard dementia. In data, time‐to‐dementia onset or its absence is available for all participants, while some measurements are missing. studies aging, one cannot rule out possibility dropout due to health issues resulting in missing not at random measurements. We, therefore, propose a pattern‐mixture sensitivity analysis not‐at‐random data framework. The implemented via multiple...
Contemporary accounts of factors that may modify the risk for age-related neurocognitive disorders highlight education and its contribution to a cognitive reserve. By this view, individuals with higher educational attainment should show weaker associations between changes in brain cognition than lower attainment. We tested prediction longitudinal data on hippocampus volume episodic memory from 708 middle-aged older using local structural equation modeling. This technique does not require...
For the tasks of hydrogen explosions prevention and environmental protection paper investigates possibility using differential absorption lidars for remote estimation concentration. The dependence atmosphere transmittance upon path length in various weather conditions, as well dependences power received laser signals concentration are investigated. results prove defining hazardous substances by systems at distances 1...10 km with account attenuation irradiation wavelengths.
Adolescents have experienced decreased aerobic fitness levels and insufficient physical activity over the past decades. While both are related to mental health, little is known concerning how they manifest in brain during this stage of development, characterized by significant psychosocial changes. The aim study examine associations between with brains' functional connectivity.Here, we examined associated local interhemispheric connectivity adolescent (n = 59), as measured resting-state...
This article proposes a Bayesian hierarchical mixture model to analyze functional brain connectivity where components represent “positively connected” and “non-connected” regions. Such an approach provides data-informed separation of reliable spurious connections in contrast arbitrary thresholding matrix. The structure the allows simultaneous inferences for entire population as well each individual subject. A new measure, posterior probability given pair regions specific subject be connected...
NSAIDs are promising agents for preventing cold injury (frigoprotectors). The influence of prophylactic administration the non-selective COX inhibitor diclofenac sodium (7 mg/kg) and highly selective COX-2 etoricoxib (5 on cyclooxygenase pathway biomarkers was studied model acute general cooling (air hypothermia at –18 °С 2 hours). Diclofenac completely prevented a decrease in body temperature, surpassing etoricoxib. In liver rats immediately after exposure, content COX-1 increased...
Abstract Adolescents have experienced decreased aerobic fitness levels and insufficient physical activity over the past decades. While both are related to mental health, little is known concerning how they manifest in brain during this stage of development, characterized by significant psychosocial changes. Previous investigations demonstrated associations with brain’s functional connectivity children adults. However, it difficult generalize these results adolescents because development has...
Various methods have recently been proposed to estimate causal effects with confidence intervals that are uniformly valid over a set of data generating processes when high-dimensional nuisance models estimated by post-model-selection or machine learning estimators. These typically require all the confounders observed ensure identification effects. We contribute showing how semiparametric inference can be obtained in presence unobserved and models. propose uncertainty which allow for...
Abstract Physical activity and exercise beneficially link to brain properties cognitive functions in older adults, but it is unclear how these results generalise other age groups. During adolescence, the undergoes significant changes, which are especially pronounced white matter. Existing studies provide contradictory evidence regarding influence of physical or aerobic-exercise on executive youth. Little also known about between both aerobic fitness with matter during puberty. For this...
Abstract Background Cognitive reserve (CR) and brain maintenance (BM) represent heuristic concepts defining general mechanisms that may underlie successful cognition in advanced age. However, a robust differentiation of both models employing unified approach is lacking. Within the framework recent NIH‐funded study (R24‐AG061421) from Reserve & Resilience collaborative network (https://reserveandresilience.com/) we have proposed an iterative process (Figure 1) to help operationalizing...
We consider a biased sample from mixture of two symmetric distributions that differ by shift parameter. The method moments and the generalized estimating equations are used to estimate unknown parameters. Adaptive estimators constructed using optimal functions those obtained moments. asymptotic behavior GEE-estimators adaptive is investigated.
Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | 1479-6848 (online)
Semiparametric inference on average causal effects from observational data is based assumptions yielding identification of the effects. In practice, several distinct identifying may be plausible; an analyst has to make a delicate choice between these models. this paper, we study three potential outcome framework: back-door assumption, which uses pre-treatment covariates, front-door mediators, and two-door assumption using covariates mediators simultaneously. We provide efficient influence...