A5080600030- Functional Brain Connectivity Studies
- Advanced Neuroimaging Techniques and Applications
- Dementia and Cognitive Impairment Research
- Alzheimer's disease research and treatments
- EEG and Brain-Computer Interfaces
- Neural dynamics and brain function
- Advanced MRI Techniques and Applications
- Neuroinflammation and Neurodegeneration Mechanisms
- Neonatal and fetal brain pathology
- Neural and Behavioral Psychology Studies
- Neuroscience and Neuropharmacology Research
- Cognitive Abilities and Testing
- Epilepsy research and treatment
- Olfactory and Sensory Function Studies
- Fetal and Pediatric Neurological Disorders
- Memory and Neural Mechanisms
- Congenital Heart Disease Studies
- Radiomics and Machine Learning in Medical Imaging
- Attention Deficit Hyperactivity Disorder
- Children's Physical and Motor Development
Stanford University
2021-2025
Stockholm University
2017-2025
Karolinska Institutet
2017-2025
Umeå University
2017-2020
Resting-state fMRI (rs-fMRI) can identify large-scale brain networks, including the default mode (DMN), frontoparietal control (FPN) and dorsal attention (DAN) networks. Interactions among these networks are critical for supporting complex cognitive functions, yet way in which they modulated across states is not well understood. Moreover, it remains unclear whether interactions similarly affected aging regardless of state. In this study, we investigated age-related differences functional...
Healthy aging is accompanied by progressive decline in cognitive performance and concomitant changes brain structure functional architecture. Age-accompanied alterations function have been characterized on a network level as weaker connections within networks along with stronger interactions between networks. This phenomenon has described age-related differences segregation. It suggested that related to associative processes are particularly sensitive deterioration segregation, possibly...
Resting-state spontaneous fluctuations have revealed individual differences in the functional architecture of brain networks. Previous research indicates that striatal network shows alterations neurological conditions but also normal aging. However, neurobiological mechanisms underlying resting-state networks (RSNs) been less explored. One candidate may account for activity is level local iron accumulation. Excessive striatum has linked to a loss structural integrity and reduced during task...
Individuals differ in how they perceive, remember, and think. There is evidence for the existence of distinct subgroups that cognitive performance within older population. However, it less clear individual differences cognition old age are linked to brain-based measures. We used latent-profile analysis on n-back working-memory (WM) identify a large sample adults (n = 181; 64-68 years). Our identified one larger normal subgroup with higher 113; 63%), second smaller 55; 31%) lower performance....
Abstract Alzheimer’s disease (AD) is a multifactorial and heterogeneous disorder, which makes early detection challenge. Studies have attempted to combine biomarkers improve AD predict progression. However, most of the existing work reports results in parallel or compares normalized findings but does not analyze data simultaneously. We tested multi-dimensional network framework, applied 490 subjects (cognitively normal [CN] = 147; mild cognitive impairment [MCI] 287; 56) from ADNI, create...
<h3>Abstract</h3> Working memory, a core function underlying many higher-level cognitive processes, requires cooperation of multiple brain regions. White matter refers to myelinated axons, which are critical interregional communication. Past studies on the association between white-matter integrity and working memory have yielded mixed findings. Using voxelwise tract-based spatial statistics analysis, we investigated this relationship in sample 328 healthy adults from 25 80 years age. Given...
We created a set of resources to enable research based on openly-available diffusion MRI (dMRI) data from the Healthy Brain Network (HBN) study. First, we curated HBN dMRI (N = 2747) into Imaging Data Structure and preprocessed it according best-practices, including denoising correcting for motion effects, susceptibility-related distortions, eddy currents. Preprocessed, analysis-ready was made openly available. quality plays key role in analysis dMRI. To optimize QC scale this large dataset,...
Abstract INTRODUCTION Amyloid beta (Aβ) plaques and hyperphosphorylated tau in the entorhinal regions are key Alzheimer's disease (AD) markers, but spatial Aβ pathways influencing pathology remain unclear. METHODS We applied predictive modeling to identify standardized uptake value ratio (SUVR) patterns that predict levels, future hippocampal volume, Preclinical Cognitive Composite (PACC) scores at 5‐year follow‐up. The model was trained on Disease Neuroimaging Initiative (ADNI) ( N = 237),...
Functional homotopy reflects the link between spontaneous activity in a voxel and its counterpart opposite hemisphere. Alterations homotopic functional connectivity (FC) are seen normal aging, with highest lowest being present sensory-motor higher-order regions, respectively. Homotopic FC relates to underlying structural connections, but neurobiological underpinnings remain unclear. The genu of corpus callosum joins symmetrical parts prefrontal cortex (PFC) is susceptible age-related...
Abstract We created resources to facilitate research on the role of human brain microstructure in development mental health disorders, based openly-available diffusion MRI (dMRI) data from Healthy Brain Network (HBN) study. First, we curated HBN dMRI (N=2747) into Imaging Data Structure and preprocessed it according best-practices, including denoising correcting for motion effects, susceptibility-related distortions, eddy currents. Preprocessed, analysis-ready was made openly available....
Amnestic mild cognitive impairment (aMCI) is a risk factor for Alzheimer's disease (AD). Multi-domain training (CT) may slow decline and delay AD onset. However, most work involves short interventions, targeting single domains or lacking active controls. We conducted single-blind randomized controlled trial to investigate the effect of 6-month, multi-domain CT on Fluid Cognition, functional connectivity in memory executive functioning networks (primary outcomes), white matter microstructural...
Brain iron overload and decreased integrity of the dopaminergic system have been independently reported as brain substrates cognitive decline in aging. Dopamine (DA), are co-localized high concentrations striatum prefrontal cortex (PFC), but follow opposing age-related trajectories across lifespan. DA contributes to cellular homeostasis activation D1-like receptors (D1DR) alleviates oxidative stress-induced inflammatory responses, suggesting a mutual interaction between these two fundamental...
Introduction: An important but under-investigated confound of functional magnetic resonance imaging (fMRI) is body posture. Although it well established that position changes cerebral blood flow, the amount cerebrospinal fluid in brain, intracranial pressure, and even firing rate certain cell types, there currently no study directly examines its effect on fMRI measurements. Moreover, typically done a supine position, which often does not correspond to how these processes are performed...
Background: Age represents the largest risk factor for Alzheimer’s disease (AD) but is typically treated as a covariate. Still, there are similarities between brain regions affected in AD and those showing accelerated decline normal aging, suggesting that distinction two might fall on spectrum. Objective: Our goal was to identify atrophy across investigate whether these overlapped with involved or where related amyloid. Methods: We used longitudinal sample of 137 healthy older adults from...
Abstract Background Olfactory impairment represents an early sensory marker of neurodegeneration, but little is known about how interindividual differences in the trajectories olfactory change relate to dementia conversion. We aimed characterize decline profiles during phases normal cognition assess their predictive value for Method trajectory dementia‐free persons (SNAC‐K; n = 1601; mean age 70.0 years) were identified using growth mixture models (GMM) repeated assessments with Sniffin’...
Abstract Brain iron overload and decreased integrity of the dopaminergic system have been independently reported as brain substrates cognitive decline in aging. Dopamine (DA), are co-localized high concentrations striatum prefrontal cortex (PFC), but follow opposing age-related trajectories across lifespan. DA contributes to cellular homeostasis activation D1-like receptors (D1DR) alleviates oxidative stress-induced inflammatory responses, suggesting a mutual interaction between these two...
Abstract Background Increased Amyloid‐beta (Aβ) is associated with the neuropathological features of Alzheimer’s disease (AD), and it has been suggested to amplify tau spreading in brain that leads neurodegeneration. However, little known about how pattern overlaps cortical microstructural neurodegeneration preclinical stages disease. Here, we utilized molecular imaging neurite orientation dispersion density (NODDI) identify pathology progression cross‐sectional data interaction degradation...
Abstract Background AD pathology affects neuronal microstructural decades before clinical manifestation of the disease. Amyloid plaques and tau tangles are key contributors to alterations in brain properties such as neurite morphology axonal transport packing, among others. It takes many years for these changes build up be reliably detected using volumetric MRI measures neurodegeneration. Here, we examined utility imaging – a biologically inspired model examining cortical microstructure...