A5031691155- Advanced Neuroimaging Techniques and Applications
- Advanced MRI Techniques and Applications
- Functional Brain Connectivity Studies
- Neonatal and fetal brain pathology
- Neural dynamics and brain function
- MRI in cancer diagnosis
- Astrophysical Phenomena and Observations
- Retinal Imaging and Analysis
- Visual perception and processing mechanisms
- Fetal and Pediatric Neurological Disorders
- Glaucoma and retinal disorders
- Astronomy and Astrophysical Research
- Particle Accelerators and Free-Electron Lasers
- Astrophysics and Cosmic Phenomena
- Reading and Literacy Development
- Particle physics theoretical and experimental studies
- High-Energy Particle Collisions Research
- Cryospheric studies and observations
- Quantum Chromodynamics and Particle Interactions
- Hearing, Cochlea, Tinnitus, Genetics
- Educational and Psychological Assessments
- Artificial Intelligence in Healthcare
- Radiomics and Machine Learning in Medical Imaging
- Photoacoustic and Ultrasonic Imaging
- Particle Detector Development and Performance
University of Washington
2021-2025
Seattle University
2023
University of Chicago
1988
IIT@MIT
1984
Herpes simplex virus (HSV) virions contain one or more functions which mediate the shutoff of host protein synthesis and degradation mRNA. HSV type 1 (HSV-1) mutants deficient in virion (vhs mutants) were isolated found to be defective their ability degrade Furthermore, it was that viral mRNAs cells infected with vhs mutant have a significantly longer functional half-life than wild-type virus-infected cells. In present study we mapped vhs1 mutation affecting 265-base-pair NruI-XmaIII...
Cross-sectional studies have linked differences in white matter tissue properties to reading skills. However, past reported a range of, sometimes conflicting, results. Some suggest that act as individual-level traits predictive of skill, whereas others skill and develop function an individual's educational experience. In the present study, we tested two hypotheses: a) diffusion reflect stable brain characteristics relate individual ability or b) is dynamic system, with learning over time. To...
Diffusion-weighted magnetic resonance imaging (dMRI) measurements and models provide information about brain connectivity are sensitive to the physical properties of tissue microstructure. Diffusional Kurtosis Imaging (DKI) quantifies degree non-Gaussian diffusion in biological from dMRI. These estimates interest because they were shown be more microstructural alterations health diseases than measures based on total anisotropy which highly confounded by dispersion fiber crossings. In this...
The validity of research results depends on the reliability analysis methods. In recent years, there have been concerns about that uses diffusion-weighted MRI (dMRI) to understand human brain white matter connections in vivo, part based methods used this field. We defined and assessed three dimensions dMRI-based tractometry, an technique assesses physical properties pathways: (1) reproducibility, (2) test-retest reliability, (3) robustness. To facilitate we provide software automates...
Abstract Background Sensory changes due to aging or disease can impact brain tissue. This study aims investigate the link between glaucoma, a leading cause of blindness, and alterations in connections. Methods We analyzed diffusion MRI measurements white matter tissue large group, consisting 905 glaucoma patients (aged 49-80) 5292 healthy individuals 45-80) from UK Biobank. Confounds group differences were mitigated by matching sub-sample controls subjects. compared classification using...
The formation of myelin, the fatty sheath that insulates nerve fibers, is critical for healthy brain function. A fundamental open question what impact being born has on myelin growth. To address this, we evaluated a large ( n = 300) cross-sectional sample newborns from Developing Human Connectome Project (dHCP). First, developed software automated identification 20 white matter bundles in individual well suited samples. Next, fit linear models quantify how T1w/T2w (a myelin-sensitive imaging...
view Abstract Citations (94) References (31) Co-Reads Similar Papers Volume Content Graphics Metrics Export Citation NASA/ADS A sharp X-ray absorption feature in the BL Lacertae object PKS 2155-304. Canizares, C. R. ; Kruper, J. An appears at 600 eV and extends to higher energies by 50 - 100 a spectrum that covers range from 0.38 1.6 keV obtained with objective grating spectrometer on Einstein Observatory. The can be fitted single edge or trough plus two power laws slopes are consistent...
Reading is a cognitive skill that requires our brain to go through myriad of changes during learning. While many studies have described how reading acquisition shapes children's function, less known about the impact on structure. Here we examined short-term causal effects training preschoolers' behavior and white matter Forty-eight English-speaking preschoolers (4y10m 6y2m) participated in randomized controlled trial where they were randomly assigned two programs: Letter program was focused...
With the great promise of deep learning, discoveries new particles at Large Hadron Collider (LHC) may be imminent. Following discovery a Beyond Standard model particle in an all-hadronic channel, learning can also used to identify its quantum numbers. Convolutional neural networks (CNNs) using jet-images significantly improve upon existing techniques chromodynamic (QCD) (‘color’) as well spin two-prong resonance substructure. Additionally, are useful determining what information jet...
We created a set of resources to enable research based on openly-available diffusion MRI (dMRI) data from the Healthy Brain Network (HBN) study. First, we curated HBN dMRI (N = 2747) into Imaging Data Structure and preprocessed it according best-practices, including denoising correcting for motion effects, susceptibility-related distortions, eddy currents. Preprocessed, analysis-ready was made openly available. quality plays key role in analysis dMRI. To optimize QC scale this large dataset,...
The validity of research results depends on the reliability analysis methods. In recent years, there have been concerns about that uses diffusion-weighted MRI (dMRI) to understand human brain white matter connections in vivo , part based methods used this field. We defined and assessed three dimensions dMRI-based tractometry, an technique assesses physical properties pathways: (1) reproducibility, (2) test-retest (3) robustness. To facilitate we provide software automates tractometry (...
The latency of neural responses in the visual cortex changes systematically across lifespan. Here, we test hypothesis that development white matter pathways mediates maturational signals. Thirty-eight children participated a cross-sectional study including diffusion magnetic resonance imaging (MRI) and magnetoencephalography (MEG) sessions. During MEG acquisition, participants performed lexical decision fixation task on words presented at varying levels contrast noise. For all stimuli tasks,...
Diffusion-weighted MRI (dMRI) provides a unique non-invasive view of human brain tissue properties. The present review article focuses on tractometry analysis methods that use dMRI to assess the properties within long-range connections comprising networks. We focus specifically major white matter tracts convey visual information. These are particularly important because vision rich information from environment supports large range daily life activities. Many diseases system associated with...
Introduction The Human Connectome Project (HCP) has become a keystone dataset in human neuroscience, with plethora of important applications advancing brain imaging methods and an understanding the brain. We focused on tractometry HCP diffusion-weighted MRI (dMRI) data. Methods used open-source software library (pyAFQ; https://yeatmanlab.github.io/pyAFQ ) to perform probabilistic tractography delineate major white matter pathways subjects that have complete dMRI acquisition ( n = 1,041)....
The neural pathways that carry information from the foveal, macular, and peripheral visual fields have distinct biological properties. optic radiations (OR) foveal thalamus to primary cortex (V1) through adjacent but separate in white matter. Here, we perform matter tractometry using pyAFQ on a large sample of diffusion MRI (dMRI) data subjects with healthy vision U.K. Biobank dataset (UKBB; N = 5382; age 45-81). We use characterize tissue properties parts OR transmit about fields, changes...
Abstract We created resources to facilitate research on the role of human brain microstructure in development mental health disorders, based openly-available diffusion MRI (dMRI) data from Healthy Brain Network (HBN) study. First, we curated HBN dMRI (N=2747) into Imaging Data Structure and preprocessed it according best-practices, including denoising correcting for motion effects, susceptibility-related distortions, eddy currents. Preprocessed, analysis-ready was made openly available....
Alpha is the strongest electrophysiological rhythm in awake humans at rest. Despite its predominance EEG signal, large variations can be observed alpha properties during development, with an increase frequency over childhood and adulthood. Here, we tested hypothesis that these changes are related to maturation of visual white matter pathways. We capitalized on a diffusion MRI (dMRI)-EEG dataset (dMRI
The formation of myelin, the fatty sheath that insulates nerve fibers, is critical for healthy brain function. A fundamental open question what impact being born on myelin growth. To address this question, we evaluated a large (n=300) cross-sectional sample newborns from Developing Human Connectome Project (dHCP). First, developed new software automated identification 20 white matter bundles in individuals well-suited samples. Next, fit linear models quantify T1w/T2w, myelin-sensitive...
Abstract Cross-sectional studies have linked differences in white matter tissue properties to reading skills. However, past reported a range of, sometimes conflicting, results. Some suggest that act as individual-level traits predictive of skill, whereas others skill and develop function an individual’s educational experience. In the present study, we tested two hypotheses: a) diffusion reflect stable brain characteristics relate skills over development or b) is dynamic system, with learning...
Abstract Changes in sensory input with aging and disease affect brain tissue properties. To establish the link between glaucoma, most prevalent cause of irreversible blindness, changes major connections, we characterized white matter properties diffusion MRI measurements a large sample subjects glaucoma (N=905; age 49-80) healthy controls (N=5,292; 45-80) from UK Biobank. Confounds due to group differences were mitigated by matching sub-sample subjects. A convolutional neural network (CNN)...
With the great promise of deep learning, discoveries new particles at Large Hadron Collider (LHC) may be imminent. Following discovery a Beyond Standard model particle in an all-hadronic channel, learning can also used to identify its quantum numbers. Convolutional neural networks (CNNs) using jet-images significantly improve upon existing techniques chromodynamic (QCD) (`color') as well spin two-prong resonance substructure. Additionally, are useful determining what information jet...
Abstract Reading is a cognitive skill that requires our brain to go through myriad of changes during learning. While many studies have described how reading acquisition shapes children’s function, less known about the impact on structure. Here we examined short-term causal effects training preschoolers’ behavior and white matter Forty-eight English-speaking preschoolers (4y10m 6y2m) participated in randomized controlled trial where they were randomly assigned two programs: Letter program was...
ABSTRACT Diffusion-weighted magnetic resonance imaging (dMRI) measurements and models provide information about brain connectivity are sensitive to the physical properties of tissue microstructure. Diffusional Kurtosis Imaging (DKI) quantifies degree non-Gaussian diffusion in biological from dMRI. These estimates interest because they were shown be more microstructural alterations health diseases than measures based on total anisotropy which highly confounded by dispersion fiber crossings....