A5011372070- Advanced Polymer Synthesis and Characterization
- Surfactants and Colloidal Systems
- Hydrogels: synthesis, properties, applications
- Dendrimers and Hyperbranched Polymers
- Polymer Surface Interaction Studies
- Nanoparticle-Based Drug Delivery
- Intracerebral and Subarachnoid Hemorrhage Research
- Electrostatics and Colloid Interactions
- RNA Interference and Gene Delivery
- biodegradable polymer synthesis and properties
- Acute Ischemic Stroke Management
- Protein purification and stability
- Membrane Separation Technologies
- Prosthetics and Rehabilitation Robotics
- Neurosurgical Procedures and Complications
- Advanced biosensing and bioanalysis techniques
- Stroke Rehabilitation and Recovery
- Enzyme Structure and Function
- Fluorine in Organic Chemistry
- Inflammasome and immune disorders
- RNA and protein synthesis mechanisms
- Photochemistry and Electron Transfer Studies
- Minerals Flotation and Separation Techniques
- Wastewater Treatment and Nitrogen Removal
- DNA and Nucleic Acid Chemistry
University of Science and Technology of China
2016-2025
Huazhong University of Science and Technology
2021-2025
Tongji Hospital
2021-2025
Shanghai Institute of Organic Chemistry
2019-2024
University of Chinese Academy of Sciences
2019-2024
University of Illinois Urbana-Champaign
2023
Chinese Academy of Sciences
2019-2023
Institute of Intelligent Machines
2021-2023
Hefei Institutes of Physical Science
2012-2023
Shenhua Group (China)
2023
The currently low delivery efficiency and limited tumor penetration of nanoparticles remain two major challenges cancer nanomedicine. Here, we report a class pH-responsive nanoparticle superstructures with ultrasensitive size switching in the acidic microenvironment for improved effective vivo drug delivery. were constructed from amphiphilic polymer directed assembly platinum-prodrug conjugated polyamidoamine (PAMAM) dendrimers, which contains ionizable tertiary amine groups rapid...
In many organic reactions, the O2 activation process involves a key step where inert ground triplet is excited to produce highly reactive singlet O2. It remains elusive what factor induces change in electron spin state of molecules, although it has been discovered that presence noble metal nanoparticles can promote generation this work, we first demonstrate surface facet parameter modulate on nanocrystals, by employing single-facet Pd nanocrystals as model system. The experimental...
The flocculation of microorganisms plays a crucial role in bioreactors, and is substantially affected by pH. However, the mechanism for such an effect remains unclear. In this work, with integrated approach, pH dependence structure surface property microbial extracellular polymeric substances (EPS), excreted from Bacillus megaterium TF10, accordingly its elucidated. From Fourier transform infrared spectra acid-base titration test results, main functional groups buffering zones EPS...
Coagulation behaviors of humic acids (HAs) aggregates in electrolyte solutions at different pHs, valences and concentrations cations were investigated using dynamic light scattering technique combination other analytical tools. For monovalent sodium chloride (NaCl) solution, its low the average hydrodynamic radius (<Rh>) kept nearly constant. However, high NaCl concentrations, <Rh> could be scaled to time t as ∝ t(a), suggesting a diffusion-limited colloid aggregation (DLCA). The coagulation...
Abstract Chiral polyfluoroarene derivatives are an important scaffold in chemistry. An unprecedented enantioselective C−H alkylation of polyfluoroarenes with alkenes is described. The reaction employs bulky chiral N‐heterocyclic carbene (NHC) ligands for nickel catalysts to enable exclusive activation bonds over C−F and complete endo ‐selective annulation excellent enantioselectivity. A wide variety fluorotetralins, compounds otherwise difficultly accessed but serve as bioisosteric analogs...
Aggregation and dissolution of poly(N-isopropylacrylamide) (PNIPAM) in water were investigated using an ultrasensitive differential scanning calorimetry (US-DSC) a pressure perturbation (PPC). US-DSC reveals that both the aggregation PNIPAM chains are greatly dependent on rate, indicating processes kinetically controlled. The hysteresis process was found to have nonequilibrium nature, which is thought be related additional hydrogen bondings formed collapsed state chains. A bimodal appearing...
Formation of stable nanobubbles in aqueous solutions water-soluble organic molecules is a spontaneous process. Using combination laser light scattering (LLS) and zeta-potential measurements, we investigated the effects salt concentration pH on their stability alpha-cyclodextrin (alpha-CD) solutions. Our results reveal that are unstable solution with higher ionic strength, just like colloidal particles an dispersion, but become more alkaline The measurement shows negatively charged electric...
Background Some species of the whitefly Bemisia tabaci complex cause tremendous losses to crops worldwide through feeding directly and virus transmission indirectly. The primary salivary glands whiteflies are critical for their transmission. However, partly due tiny size, research on is limited our knowledge these scarce. Methodology/Principal Findings We sequenced transcriptome Mediterranean B. using an effective cDNA amplification method in combination with short read sequencing...
Abstract The deactivation effects and mechanism of plasma‐activated water (PAW) against Staphylococcus aureus biofilm the inhibitory effect on regrowth capacity for surviving S. post PAW treatment were investigated in vitro. Systematic measurements bacterial cultivability, metabolic capacity, membrane integrity intracellular reactive oxygen species (ROS) concentration under two different experimental categories carried out after treatment. Considerable discovered both prolonging inducement...
Telechelic ("dumbbell-shaped") POSS-containing inorganic/organic hybrid poly(tert-butyl acrylate) (POSS-PtBA-POSS) was prepared by the combination of ATRP and copper-catalyzed azide–alkyne "click" reaction. bromoterminated PtBAs with different molecular weights were first via using a dibromo-functionalized initiator; subsequently, bromo groups transformed to azido sodium azide in DMF nucleophilic substitution. The coupling between azido-terminated PtBA alkyne-functionalized POSS successfully...
Abstract A novel disulfide core cross‐linked PEGylated polypeptide nanogel has been synthesized by a one‐step ring opening copolymerization of γ‐benzyl L ‐glutamate N ‐carboxyanhydride and ‐cystine using an amino group‐terminated poly(ethylene glycol) methyl ether as initiator. Characterization products confirms the formation with linkages size about 250 nm, these studies also confirm that this can easily be broken glutathione. Cell viability experiments show good biocompatibility...
The effect of urea on the phase transition PNIPAM was studied using differential scanning calorimetry (DSC). For a certain concentration, enthalpy change poly(N-isopropylacrylamide) (PNIPAM) aqueous solution increases with number DSC cycles, presumably due to displacement water molecules bound amide groups by at temperature higher than lower critical (LCST) and causes decrease in absolute value exothermic heat related dehydration hydrophilic interactions residues around 0. Moreover,...
The trifluoromethylselenyl group (CF3Se) has become an emerging fluorinated moiety in synthetic chemistry due to its high Hansch lipophilicity parameter and strong electron-withdrawing effect. trifluoromethylselenolation is hampered by limited methods related reagents. Herein, we designed synthesized the new electrophilic reagents, trifluoromethyl selenoxides, which are easy prepare easy-to-handle not moisture or air sensitive. selenoxides successfully applied metal-free C-H of a series...
ADVERTISEMENT RETURN TO ISSUEPREVCommunication to the...Communication the EditorNEXTHow Many Stages in Coil-to-Globule Transition of Linear Homopolymer Chains a Dilute Solution?Xiaodong Ye, Yijie Lu, Lei Shen, Yanwei Ding, Shilin Liu, Guangzhao Zhang, and Chi WuView Author Information The Hefei National Laboratory for Physical Sciences at Microscale Department Chemical Physics, University Science Technology China, Hefei, Anhui 230026, Chemistry, Chinese Hong Kong, Shatin N.T., Kong Cite...
Due to the ability easily accept and donate electrons Mn(III)N-alkylpyridylporphyrins (MnPs) can dismute O(2)(·-), reduce peroxynitrite, but also generate reactive species behave as pro-oxidants if conditions favour such action. Herein two ortho isomers, MnTE-2-PyP(5+), MnTnHex-2-PyP(5+), a meta isomer MnTnHex-3-PyP(5+), which differ greatly with regard their metal-centered reduction potential, E(1/2) (Mn(III)P/Mn(II)P) lipophilicity, were explored. Employing Mn(III)P/Mn(II)P redox system...
Soluble microbial products (SMPs) are of significant concern in the natural environment and engineered systems. In this work, poly-γ-glutamic acid (γ-PGA), which is predominantly produced by Bacillus sp., was investigated terms pH-induced conformational changes molecular interactions aqueous solutions; accordingly, its sedimentation coefficient distribution viscosity were also elucidated. Experimental results indicate that pH has a impact on structure γ-PGA. The conformation γ-PGA form...
Abstract Aims/Introduction Diabetic hearts are more vulnerable to ischemia‐reperfusion injury (I/RI). The activation of nucleotide‐binding oligomerization domain‐like receptor protein 3 (NLRP3) inflammasome can mediate the inflammatory process, and hence might contribute myocardial I/RI. Activation autophagy eliminate excess reactive oxygen species alleviate I/RI in diabetes. present study aimed investigate whether diabetic through inhibition NLRP3 activation. Materials Methods A dose 65...