Pheochromocytoma and paragangliomas (PPGLs) are rare neuroendocrine tumors carrying 25–40% pathogenic germline gene variants (PGVs). We evaluated clinical, laboratory, molecular profile of 115 patients with pathologic (14 were relatives from 8 different families recruited for genetic survey) confirmed PPGL followed in our institution. Patients classic MEN2A/MEN2B phenotypes at-risk underwent direct analysis RET proto-oncogene, the remaining had samples submitted to complete next-generation...

Aim: Peroxisome‐proliferator‐activated receptor‐γ2 (PPAR‐γ2) is a nuclear receptor that plays an important role in lipid metabolism and insulin sensitivity. The purpose of this study to investigate the association Pro12Ala polymorphism at PPAR‐γ2 gene Brazilian patients with type‐2 diabetes mellitus (T2D m ) controls (CG). Methods: Genomic DNA was obtained from 207 unrelated white people presenting T2D 170 controls. Anthropometric data included body mass index waist hip ratio. Biochemical...

This study sought to compare patients with thyroid eye disease (TED) and normal controls respect the expression of NR3C1, CHUK, IKBKB, FOS, NFKB HSD11B1 genes in orbital fat (OF) extraocular muscle (EOM).A prospective design was used evaluate 34 TED 38 healthy controls. OF harvested from 33 27 EOM biopsies were obtained 32 18 Samples examined by real-time PCR evaluated using appropriate statistical analyses a significance cut-off P < 0.05.NR3C1 mRNA levels higher (median 213 (96-376)) than...

Treatments for Graves' disease (GD) in children and adolescents include oral antithyroid drugs (ATDs), near total thyroidectomy, radioactive iodine (RAI). ATDs remain the preferred choice this age group, but because persistent remission occurs 30% of cases, RAI is becoming a common option definitive therapy.We performed review 65 medical records GD patients under 19 years who were followed between 1985 2005.The prevalence was higher females (3:1) during puberty (for both genders). If no...

We sought to assess the relationship between stimulated thyroglobulin (sTg) before radioactive iodine therapy (RIT), and dynamic risk stratification 1 year after treatment, establish utility of sTg as a predictor response in these patients. A retrospective chart review patients with differentiated thyroid cancer (DTC) who underwent RIT surgery were followed for at least year, was carried out.

Brown tumors are rare skeletal manifestations that occur in less than 2% of primary hyperparathyroidism (PHPT) cases. Even rarer is the occurrence brown tumor orbit, and few cases have been reported around world. The instance this benign has prompted us to report case treatment an orbital a patient with PHPT caused by parathyroid adenoma. We present undergoing follow-up at referral center. 60-year-old female patient, presented herself progressive swelling nasal region, epistaxis proptosis,...

The aim of this study was to evaluate the results endoscopic transsphenoidal technique for growth hormone (GH)-secreting adenomas.A retrospective analysis based on medical records 23 acromegalic patients submitted surgery. Biochemical control defined as basal GH < 1ng/ml, nadir 0.4ng/ml after glucose load and age-adjusted IGF-1 normal at last follow-up.The overall endocrinological remission rate 39.1%. While all microademonas achieved a cure, just one third macroadenomas went into remission....

Serum thyroglobulin is used as part of the early postoperative assessment differentiated thyroid cancer (DTC) since there a clear relationship between an increased risk recurrence and persistent disease after initial treatment high stimulated (ps-Tg) values. Thus, although ps-Tg above 10-30 ng/mL considered independent predictor worse prognosis, value that associated with distant metastases not defined. this was our objective. We selected 655 DTC patients from nuclear medicine department...

Abstract Disclosure: J.R. Cicogna: None. S.P. Hajnal: F.V. Barsotti: E.R. Silva: G.D. Martins: M.N. Lemos: M. Buchpiguel: N.M. Scalissi: J.V. Lima-Jr: Thyroid storm is a rare complication of hyperthyroidism characterized by multi-organ dysfunction, including liver failure. Treatment involves antithyroid drugs (ATD); however, when contra-indicated or life-threatening complications require obtention rapid euthyroidism, Therapeutic Plasma Exchange (TPE) an effective bridge to definitive...

&lt;i&gt;Background/Aim:&lt;/i&gt; In several populations, major histocompatibility complex and CTLA-4 (cytotoxic T lymphocyte antigen-4) gene polymorphisms are related to adult subjects with Graves’ disease (GD). Our aim was study the association of +49A&gt;G polymorphism in Brazilian children adults GD its correlation clinical laboratory markers severity. &lt;i&gt;Methods:&lt;/i&gt; established by polymerase chain reaction-restriction fragment length analysis 44 72 compared a stringent...

The intermediate-risk (IR) category includes tumors with different degrees of aggression. We aimed to identify the risk factors associated unfavorable response initial treatment and compare effect low/high radioactive iodine (RAI) therapy.A total 614 IR patients were selected from a database, during 1972-2015. All underwent thyroidectomy RAI therapy reclassified after 12-18 months into favorable (complete/indeterminate) group (biochemical/incomplete structural) group. A 92 assessed for late...

Introduction Surgery has been the standard treatment for Cushing's disease. Currently, endoscopic endonasal approach (EEA) is most widely used technique. However, among some endocrinologists and neurosurgeons to microscope assisted technique, there are still questions about effectiveness safety of transitioning EEA. We aim show our initial experience with such transition. Method Retrospective review medical records patients, who underwent EEA in center as a first disease, minimum 18 months...

Objective We aimed to evaluate the impact of minimal extrathyroidal extension (mETE) alone on risk recurrence papillary thyroid carcinoma (PTC). The other factors, including multifocality, age, tumor size, and stimulated thyroglobulin (sTg) values was also assessed. Subjects methods retrospectively analyzed 1,108 PTC patients from a medical institution, who presented tumors ≤ 4 cm without any adverse characteristics than mETE. Patients were classified according their response initial...

Objective To compare the long-term medical costs of active surveillance (AS), partial thyroidectomy (PT), and total (TT) in patients with low-risk papillary thyroid microcarcinoma (PTMC) receiving care covered by Brazilian Public Health System. Materials methods After reviewing AS cohorts our own data, we created a model AS, PT, TT flow for PTMC over 10, 20, 30 years. The included those associated diagnosis, surgery, follow-up. We considered [...]

Abstract Disclosure: L.D. Santos: None. G. Oliveira Martins: L. Costa Figueiredo: M. Nascimento de Lemos: J.V. Lima: L.A. Alvares: E.N. Sakane: N. Scalissi: Post-surgical hypoparathyroidism is an event that may occur, especially after extensive procedures in the cervical region. There are few long-term follow-up studies on individuals who develop permanent post-surgical and its complications. Objective: This study aims to assess clinical laboratory characteristics of patients diagnosed with...

Abstract Disclosure: L.D. Santos: None. G. Oliveira Martins: J.V. Lima: L.A. Alvares: M.N. Lemos: L. Costa Figueiredo: E.N. Sakane: N. Scalissi: Introduction: The consensus published in 2022 suggests that a parathyroid hormone (PTH) level below 10 pg/mL may predict permanent hypoparathyroidism. However, these data have not yet been tested the Brazilian population.Objective: To assess clinical and laboratory characteristics of patients undergoing anterior cervical surgery, aiming to identify...

Abstract Disclosure: M.N. Lemos: None. G.D. Martins: J.R. Cicogna: N.M. Scalissi: J.V. Lima-Jr: Background: X-linked adrenal hypoplasia congenita caused by a pathogenic variant in NR0B1/DAX-1 is rare inherited disorder. Patients with are usually diagnosed primary insufficiency infancy or early childhood and present hypogonadotropic hypogonadism during adolescence. Clinical Case: Our male patient first presented crisis at the age of 11 years, managed glucocorticoids (prednisolone)...

<title>Abstract</title> <bold>Context</bold>: Pheochromocytomas (Pheo) and paragangliomas (PGL) (PPGL) are catecholamine-producing tumours, whose functionality is confirmed by elevated plasma (Pl) and/or 24-h urinary (Ur) metanephrines (MN). <bold>Objective/Design</bold>: We review clinical, hormonal, imaging aspects of 116 patients studied prospectively: 93 Pheo, 22 PGL, one Pheo plus PGL. <bold>Results</bold>: Twenty-five % PPGL were discovered incidentally. Systemic arterial hypertension...

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Fungal infections can affect the adrenal glands, causing primary insufficiency (PAI). Although endemic to South America, paracoccidioidomycosis (PCM), which lead PAI, has gained global relevance with increase in international travel and migration.The present report describes 3 patients PAI caused by PCM.Patients cases 1 2 both reported indisposition, asthenia, nausea, hyperpigmentation of skin, hypotension, weight loss. Complementary exams confirmed due PCM. Case was serologically diagnosed....

Abstract Disclosure: A.B. Figueiredo: None. C.A. Baptista: C.R. Xavier: A.K. Nascimento: R.L. Dolci: A.L. dos Santos: J. Ethel: C.T. da Silva: N.M. Scalissi: J.V. Lima: Introduction: Patients with Cushing's syndrome (CS) have a 4-fold increased risk of thrombosis, due to synthesis Von Willebrand factor and cortisol-stimulated fibrinogen, as well type 1 plasminogen activator inhibitor. The first 4 weeks after surgery are the period most susceptible thromboembolism worsening coagulation...

Although thyroid microcarcinoma (TMC) usually has a favorable prognosis, some patients present higher risk of disease recurrence or persistence. Thus, we aimed at identifying possible factors associated with an incomplete response to therapy in TMC.This was retrospective study 517 TMC treated total thyroidectomy, without radioactive iodine (RAI) therapy, reclassified after 1.1 ± 0.4 years according the treatment into "favourable" (excellent/indeterminate) "unfavorable"...