A5029146832- Catalytic C–H Functionalization Methods
- Radical Photochemical Reactions
- Asymmetric Synthesis and Catalysis
- Sulfur-Based Synthesis Techniques
- Cyclopropane Reaction Mechanisms
- Synthesis and Catalytic Reactions
- Oxidative Organic Chemistry Reactions
- Asymmetric Hydrogenation and Catalysis
- Catalytic Alkyne Reactions
- Synthetic Organic Chemistry Methods
- Axial and Atropisomeric Chirality Synthesis
- Chemical Synthesis and Reactions
- Fluorine in Organic Chemistry
- Chemical Synthesis and Analysis
- Synthesis of Indole Derivatives
- Advanced Photocatalysis Techniques
- Organic Chemistry Cycloaddition Reactions
- Synthesis and Biological Evaluation
- Synthesis of β-Lactam Compounds
- Catalytic Cross-Coupling Reactions
- Crystallization and Solubility Studies
- Synthesis and Characterization of Pyrroles
- Chemical synthesis and alkaloids
- Phosphorus compounds and reactions
- X-ray Diffraction in Crystallography
Central China Normal University
2016-2025
Wuhan Institute of Technology
2023-2025
Henan Normal University
2003-2025
Lanzhou Institute of Chemical Physics
2017-2025
Chinese Academy of Sciences
2017-2025
Shanghai Institute of Organic Chemistry
2019
Chemical Synthesis Lab
2018
Leibniz Institute for Catalysis
2012-2016
Collaborative Innovation Center of Chemical Science and Engineering Tianjin
2014
Aarhus University
2012
ConspectusVisible-light photocatalysis has recently received increasing attention from chemists because of its wide application in organic synthesis and significance for sustainable chemistry. This catalytic strategy enables the generation various reactive species, frequently without stoichiometric activation reagents under mild reaction conditions. Manipulation these intermediates can result numerous synthetically useful bond formations a controllable manner.In this Account, we describe our...
To shed light on: The title reaction allows the generation of a variety functionalized phenols and analogues using [Ru(bpy)3Cl2]⋅6 H2O as photocatalyst under very mild conditions. This not only incorporates an oxygen atom from molecular directly into product, but also expands application visible-light photocatalysis. bpy=bipyridine. Detailed facts importance to specialist readers are published "Supporting Information". Such documents peer-reviewed, copy-edited or typeset. They made available...
Splitting of alcohols into hydrogen and corresponding carbonyl compounds has potential applications in production chemical industry. Herein, we report that a heterogeneous photocatalyst (Ni-modified CdS nanoparticles) could efficiently split aldehydes or ketones stoichiometric manner under visible light irradiation. Optimized apparent quantum yields 38%, 46%, 48% were obtained at 447 nm for dehydrogenation methanol, ethanol, 2-propanol, respectively. In the case turnover number greater than...
Visible-light-induced photocatalytic decarboxylative alkynylations of carboxylic acids have been developed for the first time. The reaction features extremely mild conditions, broad substrate scope, and avoids additional oxidants. Importantly, a carbonylative alkynylation has also carried out in presence carbon monoxide (CO) under which affords valuable ynones high yields at room temperature.
Abstract A photocatalytic formal [3+2] cycloaddition of 2 H ‐azirines with alkynes has been achieved under irradiation by visible light in the presence organic dye photocatalysts. This transformation provides efficient access to highly functionalized pyrroles good yields and applied synthesis drug analogues. primary trial photocascade catalysis merging energy transfer redox neutral reactions was shown be successful.
An unprecedented α-allylation of amines was achieved by combining palladium catalysis and visible-light photoredox catalysis. In this dual process, the catalytic generation allyl radical from corresponding π-allylpalladium intermediate without additional metal reducing reagents (redox-neutral). Various allylation products were obtained in high yields through cross-coupling under mild reaction conditions. Moreover, transformation applied to formal synthesis 8-oxoprotoberberine derivatives...
The first copper-catalyzed asymmetric decarboxylative [4 + 1] cycloaddition of propargylic carbamates and sulfur ylides was successfully developed. This strategy led to a series chiral indolines with synthetically flexible alkyne groups in good yields high enantio- diastereoselectivities (up 99% yield, 98% ee, >95:5 dr). A possible mechanism stereoinduction mode copper–allenylidenes were proposed as the dipolar intermediate.
Catalytic asymmetric cycloadditions of reactive ketene intermediates provide new opportunities for the production chiral heterocyclic molecules. Though known over 100 years, ketenes still remain underexplored in field transition-metal (TM)-catalyzed because (1) ketenes, as highly electron-deficient species, are possibly unstable to low-valence TMs (i.e., decarbonylation or aggregation) and (2) conventional thermal synthesis from acyl chlorides amines may be incompatible with TM catalysis...
A novel visible-light-responsive chiral ligand has been developed by grafting a triplet state photosensitizer to bisoxazoline ligands. Complexation of this with Ni(acac)2 results in powerful catalyst for the asymmetric oxidation reaction β-ketoesters, which uses oxygen or air as green oxidant and visible light sunlight ideal driving force. Using protocol, products containing α-hydroxy-β-dicarbonyl motif are produced high yields excellent enantiopurities.
An enantioselective [5+2] cycloaddition of vinylethylene carbonates and α-diazoketones was achieved for the first time by merging photoactivation asymmetric Pd catalysis. The key to success this method is trapping Pd-containing, 1,5-dipolar intermediates ketenes, a class reactive C2 synthons, which were generated in an situ traceless manner under visible light irradiation. Through trapping, variety 7-membered lactones bearing challenging chiral quaternary stereocenters can be accessed facile...
The first asymmetric propargylic radical cyanation was realized through a dual photoredox and copper catalysis. An organic photocatalyst serves to both generate propargyl radicals oxidize Cu(I) species Cu(II) species. A chiral Cu complex functions as an efficient organometallic catalyst resemble the cyanide in enantio-controlled manner. Thus, diverse range of optically active cyanides were produced with high reaction efficiency enantioselectivities (28 examples, 57–97% yields 83–98% ee)....
Abstract A novel and efficient CP bond formation reaction of diarylphosphine oxides with aryl iodides was achieved by combining nickel catalysis visible‐light‐induced photoredox catalysis. This dual‐catalytic showed a broad substrate scope, excellent functional group tolerance, afforded the corresponding products in good to yields. Compared previously reported use photoredox/nickel dual construction CC bonds, methodology described herein observed be first allow for C‐heteroatom formation.
1,3-Dienes are readily available feedstocks that widely used in the laboratory and industry. However, potential of converting 1,3-dienes into value-added products, especially chiral has not yet been fully exploited. By synergetic photoredox/copper catalysis, we achieve first visible-light-induced, enantioselective carbocyanation by using carboxylic acid derivatives trimethylsilyl cyanide. Under mild neutral conditions, a diverse range allyl cyanides produced generally good efficiency with...
Grignard addition is one of the most important methods used for syntheses alcohol compounds and has been known over a hundred years. However, research on asymmetric catalysis relies use organometallic nucleophiles. Here, we report first visible-light-induced cobalt-catalyzed reductive Grignard-type synthesizing chiral benzyl alcohols (>50 examples, up to 99% yield, ee). This methodology advantages mild reaction conditions, good functionality tolerance, excellent enantiocontrol, avoidance...