A5003535808- Influenza Virus Research Studies
- Respiratory viral infections research
- Animal Disease Management and Epidemiology
- Viral gastroenteritis research and epidemiology
- Viral Infections and Vectors
- Immune Response and Inflammation
- COVID-19 epidemiological studies
- Virus-based gene therapy research
- RNA and protein synthesis mechanisms
- Bacteriophages and microbial interactions
- interferon and immune responses
- Genomics and Phylogenetic Studies
- Xenotransplantation and immune response
- Animal Virus Infections Studies
- Viral Infections and Immunology Research
- Bacterial Genetics and Biotechnology
- Pneumonia and Respiratory Infections
- Animal Genetics and Reproduction
- Virology and Viral Diseases
- Immune Cell Function and Interaction
- SARS-CoV-2 and COVID-19 Research
- Probiotics and Fermented Foods
- Biomarkers in Disease Mechanisms
- Tissue Engineering and Regenerative Medicine
- Bacillus and Francisella bacterial research
Peter Doherty Institute
2016-2025
The Royal Melbourne Hospital
2019-2025
Victorian Infectious Diseases Reference Laboratory
2014-2025
The University of Melbourne
2019-2025
Guangzhou Medical University
2025
The University of Western Australia
2025
Guangdong Provincial Hospital of Traditional Chinese Medicine
2022-2024
Guangzhou University of Chinese Medicine
2024
Center for High Pressure Science & Technology Advanced Research
2022-2024
Boston University
2023-2024
Abstract The clinical response to influenza infection ranges from mild disease severe pneumonia and it remains unclear whether the inflammatory is protective or pathogenic. We have defined a novel role for neutrophils in ameliorating lung injury during infection, thereby limiting development of disease. Infection neutrophil-depleted mice with virus HKx31 (H3N2) led rapid weight loss, pneumonia, death. Neutropenia was associated enhanced replication respiratory tract; however, viral titers...
Abstract Human respiratory syncytial virus (RSV) is an important cause of acute infection with the most severe disease in young and elderly. Non-pharmaceutical interventions travel restrictions for controlling COVID-19 have impacted circulation viruses including RSV globally, particularly Australia, where during 2020 normal winter epidemics were notably absent. However, late 2020, unprecedented widespread outbreaks occurred, beginning spring, extending into summer across two widely separated...
A complex interplay of viral, host, and ecological factors shapes the spatio-temporal incidence evolution human influenza viruses. Although considerable attention has been paid to viruses, a lack equivalent data means that an integrated evolutionary epidemiological framework until now not available for B despite their significant disease burden. Through analysis over 900 full genomes from collection more than 26,000 strains Australia New Zealand, we reveal fundamental differences in...
In March 2010, an outbreak of low pathogenicity avian influenza A (H10N7) occurred on a chicken farm in Australia. After processing clinically normal birds from the farm, 7 abattoir workers reported conjunctivitis and minor upper respiratory tract symptoms. Influenza virus subtype H10 infection was detected 2 workers.
Oseltamivir resistance in A(H1N1)pdm09 influenza is rare, particularly untreated community cases. Sustained transmission has not previously been reported.Influenza specimens from the Asia-Pacific region were collected through sentinel surveillance, hospital, and general practitioner networks. Clinical epidemiological information was on patients infected with oseltamivir-resistant viruses.Twenty-nine (15%) of 191 viruses between May September 2011 Hunter New England (HNE), Australia,...
ABSTRACT It is widely recognized that sialic acid (SA) can mediate attachment of influenza virus to the cell surface, and yet specific receptors entry are not known. For many viruses, a definitive demonstration receptor function has been achieved when nonpermissive cells rendered susceptible infection following transfection gene encoding putative receptor. virus, such approaches have confounded by abundance SA on mammalian so it difficult identify lines infection. We examined Lec2 Chinese...
In 2017, influenza seasonal activity was high in the southern hemisphere. We present interim vaccine effectiveness (VE) estimates from Australia. Adjusted VE low overall at 33% (95% confidence interval (CI): 17 to 46), 50% CI: 8 74) for A(H1)pdm09, 10% -16 31) A(H3) and 57% 41 69) B. For A(H3), poorer those vaccinated current prior seasons.
Escherichia coli INS33 was isolated from the urinary tract of an infected patient. It resistant to ampicillin, chloramphenicol, spectinomycin, streptomycin, sulfafurazole, tetracycline and trimethoprim. PCR screening revealed presence a class 1 integron that harboured two new gene cassettes, designated dfrA17 aadA5. The cassette 91% identical known dfrA7 cassette. aadA5 95% over first 830 bp aadA4, but lacked IS26 element found at 3' end this truncated Cloning expression region demonstrated...
This study examined postconcussion-like symptoms in a group of university students and explored their relationships to neuropsychological function performance. A sample 124 was recruited. All the participants received Rivermead Post-Concussion Symptoms Questionnaire (RPQ) completed comprehensive set tests. They reported relatively high base rate symptoms. The most frequently endorsed items were "fatigue" (76.9%), "longer time think" (60.3%), "poor concentration" (58.7%), "sleep disturbance"...
In April 2009, an A(H1N1) influenza virus of swine lineage was detected in humans the USA, and just over a month has infected 10,000 people more than 40 countries.To determine performance Binax Now, BD Directigen EZ, Quidel QuickVue rapid point-of-care (POC) tests for detection recently emerged virus.Swine human seasonal strains were cultured then diluted to specific infectivity titres. Viral dilutions assayed by POC real-time RT-PCR.All three successfully viruses at levels between 10(3)...
A novel influenza A(H1N1)2009 variant with mildly reduced oseltamivir and zanamivir sensitivity has been detected in more than 10% of community specimens Singapore 30% samples from northern Australia during the early months 2011. The variant, which also other regions Asia-Pacific, contains a S247N neuraminidase mutation. When combined H275Y mutation, as an oseltamivir-treated patient, dual S247N+H275Y mutant had extremely high resistance.
Abstract Acquired immune responses elicited to recent strains of seasonal H1N1 influenza viruses provide limited protection against emerging A(H1N1) pandemic viruses. Accordingly, pre-existing or rapidly induced innate defenses are critical importance in limiting early infection. Respiratory secretions contain proteins the system, including members collectin and pentraxin superfamilies. These mediate potent antiviral activity act as an initial barrier In this study, we have examined...
ABSTRACT Avian influenza virus (AIV) surveillance in Antarctica during 2013 revealed the prevalence of evolutionarily distinct viruses H11N2 subtype Adélie penguins. Here we present results from continued AIV on Antarctic Peninsula 2014 and 2015. In addition to detection H11 a snowy sheathbill 2014, isolated novel H5N5 chinstrap penguin Gene sequencing phylogenetic analysis that detected had >99.1% nucleotide similarity 2013, suggesting this over multiple years. However, showed genome...
Abstract How innate and adaptive immune responses work in concert to resolve influenza disease is yet be fully investigated one single study. Here, we utilize longitudinal samples from patients hospitalized with acute understand these responses. We report the dynamics of 18 important parameters, related clinical, genetic virological factors, across different severity levels. Influenza correlates increases IL-6/IL-8/MIP-1α/β cytokines lower antibody Robust activation circulating T follicular...
Xenotransplantation using pig organs or tissues may alleviate the human donor organ shortage. However, one concern is potential transmission of pathogens to humans, especially endogenous retroviruses (PERV), which infect cell lines in vitro. In this report, cross-species vivo PERV by xenotransplantation was studied a severe combined immunodeficient (SCID) mouse model.Twenty-one SCID mice were transplanted with fetal pancreatic cells and left for periods from three 41 weeks before being...
Evidence suggests that induction of heme oxygenase-1 (HO-1) inhibits proliferation vascular smooth muscle cells and intimal thickening after arterial injury, therapeutic molecules induce HO-1. Probucol is the only oral drug restenosis in humans animals, although its underlying mechanism remains unclear.Aortas were harvested from New Zealand White rabbits fed normal or 0.75% (wt/wt) probucol-fortified chow, with without endothelial denudation abdominal aorta on day 21, analyzed for oxygenase...
Abstract Relatively few international comparisons of the incidence influenza related to climate parameters have been performed, particularly in Eastern hemisphere. In this study, and data such as temperature, relative humidity, rainfall, from cities at different latitudes with contrasting climates: Singapore, Hong Kong (China), Ulaanbaatar (Mongolia), Vancouver (Canada), three Australian (Brisbane, Melbourne Sydney) were examined determine whether there was any overall relationship between...
Pandemic H1N1 influenza virus is of global health concern and currently the predominant subtype circulating in southern hemisphere 2010 winter. The has changed little since it emerged 2009, however, this report we describe several genetically distinct changes pandemic virus. These variants were first detected Singapore early have subsequently spread through Australia New Zealand. At stage, these signature haemagglutinin neuraminidase proteins not resulted significant antigenic which might...