A5015431701- Respiratory viral infections research
- Influenza Virus Research Studies
- Viral gastroenteritis research and epidemiology
- Pneumonia and Respiratory Infections
- Congenital Diaphragmatic Hernia Studies
- Viral Infections and Vectors
- COVID-19 epidemiological studies
- Neonatal Respiratory Health Research
- Parvovirus B19 Infection Studies
- Cerebrospinal fluid and hydrocephalus
- Viral Infections and Outbreaks Research
- Cystic Fibrosis Research Advances
- Tracheal and airway disorders
- Mosquito-borne diseases and control
- Genomics and Phylogenetic Studies
- Vector-borne infectious diseases
- Respiratory Support and Mechanisms
- Congenital Anomalies and Fetal Surgery
- Viral Infections and Immunology Research
- Animal Disease Management and Epidemiology
- Gastrointestinal disorders and treatments
- COVID-19 Clinical Research Studies
- Escherichia coli research studies
- Bacteriophages and microbial interactions
Pathwest Laboratory Medicine
2013-2025
Queen Elizabeth II Medical Centre
2013-2025
Curtin University
2019
Abstract Public health measures targeting coronavirus disease 2019 have potential to impact transmission of other respiratory viruses. We found 98.0% and 99.4% reductions in syncytial virus influenza detections, respectively, Western Australian children through winter 2020 despite schools reopening. Border closures likely been important limiting external introductions.
The coronavirus disease pandemic was declared in March 2020, as the southern hemisphere’s winter approached. Australia expected co-circulation of severe acute respiratory syndrome 2, influenza and other seasonal viruses. However, notifications were 7,029 (March–September) compared with an average 149,832 for same period 2015–2019*, despite substantial testing. Restrictions on movement within into may have temporarily eliminated influenza. Other pathogens also showed remarkably changed activity 2020.
Abstract Human respiratory syncytial virus (RSV) is an important cause of acute infection with the most severe disease in young and elderly. Non-pharmaceutical interventions travel restrictions for controlling COVID-19 have impacted circulation viruses including RSV globally, particularly Australia, where during 2020 normal winter epidemics were notably absent. However, late 2020, unprecedented widespread outbreaks occurred, beginning spring, extending into summer across two widely separated...
Following a relative absence in winter 2020, large resurgence of respiratory syncytial virus (RSV) detections occurred during the 2020/2021 summer Western Australia. This seasonal shift was linked to SARS-CoV-2 public health measures. We examine epidemiology and RSV testing respiratory-coded admissions, compare clinical phenotype RSV-positive admissions between 2019 2020.At single tertiary paediatric centre, International Classification Diseases, 10th edition Australian Modification-coded...
Abstract Genomics is a cornerstone of modern pathogen epidemiology yet demonstrating transmission in One Health context challenging, as strains circulate and evolve within between diverse hosts environments. To identify phylogenetic linkages better define relevant measures genomic relatedness context, we collated 5471 Escherichia coli genome sequences from Australia originating humans ( n = 2996), wild animals 870), livestock 649), companion 375), environmental sources 292) food 289)...
In 2017, influenza seasonal activity was high in the southern hemisphere. We present interim vaccine effectiveness (VE) estimates from Australia. Adjusted VE low overall at 33% (95% confidence interval (CI): 17 to 46), 50% CI: 8 74) for A(H1)pdm09, 10% -16 31) A(H3) and 57% 41 69) B. For A(H3), poorer those vaccinated current prior seasons.
Non-pharmaceutical interventions (NPIs) to reduce SARS-CoV-2 transmission disrupted respiratory virus seasonality. We examined the unusual return of human metapneumovirus (hMPV) in Western Australia following a period absence 2020. analysed hMPV laboratory testing data from 1 January 2017 31 December 2021. Whole-genome sequencing selected hMPV-positive samples was performed using tiled-amplicon approach. Following an spring 2020, surge observed during wet summer season tropical Northern...
Abstract Background Respiratory syncytial virus (RSV) seasonality is dependent on the local climate. We assessed stability of RSV prior to SARS‐CoV‐2 pandemic in Western Australia (WA), a state spanning temperate and tropical regions. Method laboratory testing data were collected from January 2012 December 2019. WA was divided into three regions determined by population density climate: Metropolitan, Northern Southern. Season threshold calculated per region at 1.2% annual cases, with onset...
Objective: Circulation patterns of influenza and other respiratory viruses have been globally disrupted since the emergence coronavirus disease (COVID-19) introduction public health social measures (PHSMs) aimed at reducing severe acute syndrome 2 (SARS-CoV-2) transmission. Methods: We reviewed virus laboratory data, Google mobility data PHSMs in five geographically diverse regions Australia New Zealand. also described activity from January 2017 to August 2021. Results: observed a change...
Primary aim was to review severe acute respiratory infections (SARI) hospitalisations caused by syncytial virus (RSV) in children aged < 2 years paediatric hospitals Australia. Secondary aims included RSV subtyping, assessing seasonality and contributing the World Health Organisation's surveillance programme. We prospectively reviewed medical records of (< age) with a confirmed SARI who were admitted one four major Australian had sample analysed Polymerase Chain Reaction (PCR). A detailed...
The Australian Therapeutic Goods Administration approved the use of nirsevimab, a long-acting monoclonal antibody for prevention Respiratory Syncytial Virus (RSV), in November 2023. Western Australia (WA) implemented combination nirsevimab administration strategies designed to protect all infants starting April 2024, before epidemic season. We developed dynamic transmission model predict impact WA's RSV immunisation program on infant hospitalisations. Our is calibrated monthly-aggregated...
Background: Nirsevimab is a long-acting monoclonal antibody used to prevent respiratory syncytial virus (RSV) infection in infants and high-risk children. During the 2024 RSV season Western Australia, 23,525 doses were administered entering their first season, 1,233 at-risk In this context, selection spread of escape variants potential concern. This study aimed investigate nirsevimab-binding site mutations using both clinical wastewater data. Methods: We performed whole-genome sequencing on...
Abstract Human respiratory syncytial virus (RSV) is an important cause of acute infection (ARI) with the most severe disease in young and elderly 1,2 . Non-pharmaceutical interventions (NPIs) travel restrictions for controlling COVID-19 have impacted circulation viruses including RSV globally, particularly Australia, where during 2020 normal winter epidemics were notably absent 3–6 However, late 2020, unprecedented widespread outbreaks occurred, beginning spring, extending into summer across...
The incidence of respiratory syncytial virus (RSV) in adults is inadequately defined and the impact SARS-CoV-2-related non-pharmaceutical interventions (NPIs) underexplored. Using laboratory data, we described detection rate RSV ≥16 years Western Australia (WA) between 2017 2023. With exception 2020, detections rose annually 2023, reaching 50.7 per 100,000 2023 (95% confidence interval [CI], 47.9–53.8). testing expanded considerably across study period, with more than five times total. was...
Respiratory syncytial virus (RSV) reinfection in children is poorly understood. We examined the incidence, characteristics, and outcomes of hospital-attended RSV reinfections <16 years Western Australia between 2012 2022. Individuals with repeat detections ≥56 days apart were identified using laboratory data. The incidence first five life was estimated total birth population from to 2017. Clinical data on a subset episodes obtained two metropolitan pediatric centers. A 466 identified....
To ascertain the full mortality of influenza and other respiratory viruses, testing community autopsy specimens is essential.Respiratory virus PCR culture were performed on 2418 fresh unfrozen samples collected from 1611 coronial cases where death was either unknown or infection suspected, July 2007 to June 2011, detect common viruses in children adults, using standardized microbiological testing.The positive rate 8·3% (134 cases) with a peak 28% (42 151 under 10 years age. Influenza...
This study compares the frequency and severity of influenza A/H1N1pdm09 (A/H1), A/H3N2 (A/H3) other respiratory virus infections in hospitalised patients. Data from 17 332 adult patients admitted to Sir Charles Gairdner Hospital, Perth, Western Australia, with a illness between 2012 2015 were linked data containing reverse transcription polymerase chain reaction results for viruses including A/H1, A/H3, B, human metapneumovirus, syncytial parainfluenza. Of these, 1753 (10.1%) had test...
Western Australian laboratory data demonstrated a decrease in human metapneumovirus (hMPV) detections through 2020 associated with SARS-CoV-2-related non-pharmaceutical interventions (NPIs), followed by subsequent surge metropolitan region mid-2021. We aimed to assess the impact of hMPV on paediatric hospital admissions and contribution changes testing.All respiratory-coded children aged <16 years at tertiary centre between 2017 2021 were matched respiratory virus testing data. Patients...
In 2016, modified CO2 -baited encephalitis virus surveillance (EVS) traps were evaluated for flavivirus in the Northern Territory, Australia. The fitted with honey-soaked nucleic acid preservation cards (FTATM ) mosquitoes to expectorate while feeding on cards. Cards tested presence of selected arboviruses, two testing positive Kunjin and Alfuy, sentinel chickens parallel also showed activity at same time. results from vector mosquito rates indicate that EVS coupled honey-baited FTATM are an...