A5040858155- Dermatology and Skin Diseases
- Skin and Cellular Biology Research
- Psoriasis: Treatment and Pathogenesis
- Allergic Rhinitis and Sensitization
- Cutaneous lymphoproliferative disorders research
- Acne and Rosacea Treatments and Effects
- Autoimmune Bullous Skin Diseases
- Urticaria and Related Conditions
- Mast cells and histamine
- Dermatological and COVID-19 studies
- Food Allergy and Anaphylaxis Research
- Nonmelanoma Skin Cancer Studies
- Contact Dermatitis and Allergies
- Biotin and Related Studies
- Skin Diseases and Diabetes
- Drug-Induced Adverse Reactions
- Colorectal and Anal Carcinomas
- Autoimmune and Inflammatory Disorders
- Cancer Immunotherapy and Biomarkers
- Streptococcal Infections and Treatments
- Histiocytic Disorders and Treatments
- Parvovirus B19 Infection Studies
- Retinoids in leukemia and cellular processes
- Alzheimer's disease research and treatments
- Chemotherapy-related skin toxicity
University of Mississippi Medical Center
2018-2025
State Street (United States)
2023-2025
Australian Government
2025
Department of Health and Aged Care
2025
Government of Western Australia Department of Health
2025
Yale University
2025
Texas Tech University
2024
University of Mississippi
2024
Jackson Memorial Hospital
2023
Northwestern University
2016-2022
Abstract Genomics is a cornerstone of modern pathogen epidemiology yet demonstrating transmission in One Health context challenging, as strains circulate and evolve within between diverse hosts environments. To identify phylogenetic linkages better define relevant measures genomic relatedness context, we collated 5471 Escherichia coli genome sequences from Australia originating humans ( n = 2996), wild animals 870), livestock 649), companion 375), environmental sources 292) food 289)...
Central conducting lymphatic anomaly (CCLA) due to congenital maldevelopment of the lymphatics can result in debilitating and life-threatening disease with limited treatment options. We identified 4 individuals CCLA, lymphedema, microcystic malformation pathogenic, mosaic variants KRAS. To determine functional impact these identify a targeted therapy for individuals, we used primary human dermal endothelial cells (HDLECs) zebrafish larvae model dysplasia. Expression p.Gly12Asp p.Gly13Asp...
Dystrophic neurites (also termed axonal spheroids) are found around amyloid deposits in Alzheimer's disease (AD), where they impair electrical conduction, disrupt neural circuits and correlate with AD severity. Despite their importance, the mechanisms underlying spheroid formation remain incompletely understood. To address this, we developed a proximity labeling approach to uncover proteome of spheroids human postmortem mouse brains. Additionally, established induced pluripotent stem cell...
Abstract Background High-protein diets are often enriched with branched-chain amino acids (BCAAs) known to enhance protein synthesis and provide numerous physiological benefits, but recent studies reveal their association obesity diabetes. In support of this, or BCAA supplementation is shown disrupt glucose metabolism while restriction improves it. However, it not clear if these primary, direct effects BCAAs secondary other changes during chronic manipulation dietary BCAAs. Methods...
Systemic drug-related intertriginous and flexural exanthema (SDRIFE) is a cutaneous reaction, characterized by 5 diagnostic criteria (Table I).1 We report on 3 patients with SDRIFE induced radio contrast media (RCM) describe the dermatologist's role in treatment prevention of SDRIFE.
Abstract Background/Objectives Though maculopapular cutaneous mastocytosis is the most common form of pediatric mastocytosis, it remains unclear which patients will experience severe symptoms. We sought to better define presentation and systemic signs symptoms in with mastocytosis. Methods analyzed retrospective data on 227 diagnosed prior age 15 years from five US clinical sites. collected signs, symptoms, onset, laboratory testing. Results Median onset was 3 months, 94% presenting 2 (range...
The ASCEND Trial [n=110] is a Phase 3, vehicle-controlled study of subjects >6 years age with moderate-severe (IGA >3; 10-90% BSA involvement) XLRI or ARCI treated TMB-001 0.05%. 32 substudy (Maximal Use Study [MuST]) apply open-label 0.05% BID to 75-90% for 15 days (D) collect pharmacokinetics (PK) isotretinoin (ISO), 4-oxo-isotretinoin (4-O-ISO), tretinoin (TR), and 4-oxo-tretinoin (4-O-TR). Analysis first 13 MuST contemporaneous PK in healthy male volunteers (HV) administered oral 80 mg...
Introduction: Epidermolysis bullosa with pyloric atresia (EB-PA) is a rare subtype of the broader bullous disorder known as epidermolysis resulting from mutations in basal keratinocyte proteins, most notably plectin or α6β4 integrin. Objective: Our case aims to highlight both cutaneous and extracutaneous manifestations this entity that lead diagnosis guide management. Case: We report EB-PA newborn born skin fragility respiratory distress, later found have PLEC genes on chromosome 8. In...