A5008173815- Head and Neck Cancer Studies
- Cancer Cells and Metastasis
- Lung Cancer Research Studies
- Estrogen and related hormone effects
- Cellular Mechanics and Interactions
- Plant Disease Resistance and Genetics
- Molecular Biology Techniques and Applications
- Lung Cancer Treatments and Mutations
University of Helsinki
2018-2021
Breast cancer is now globally the most frequent and leading cause of women's death. Two thirds breast cancers express luminal estrogen receptor-positive (ERα + ) phenotype that initially responsive to antihormonal therapies, but drug resistance emerges. A major barrier understanding ERα-pathway biology therapeutic discoveries restricted repertoire ERα models. The not stable in cultured cells for reasons fully understood. We examine 400 patient-derived epithelial explant cultures (PDECs)...
Abstract There is an unmet need for effective targeted therapies patients with advanced head and neck squamous cell carcinoma (HNSCC). We correlated gene expression, copy numbers, point mutations in 45 human papillomavirus–negative HNSCC lines the sensitivity to 220 anticancer drugs discover predictive associations genetic alterations. The drug response profiles revealed diverse efficacy of tested across lines. Several genomic abnormalities expression differences were associated mTOR, MEK,...
<div>Abstract<p>There is an unmet need for effective targeted therapies patients with advanced head and neck squamous cell carcinoma (HNSCC). We correlated gene expression, copy numbers, point mutations in 45 human papillomavirus–negative HNSCC lines the sensitivity to 220 anticancer drugs discover predictive associations genetic alterations. The drug response profiles revealed diverse efficacy of tested across lines. Several genomic abnormalities expression differences were...