A5003101151- Renal and related cancers
- Organ Donation and Transplantation
- Renal and Vascular Pathologies
- Cell Adhesion Molecules Research
- Pluripotent Stem Cells Research
- Cancer-related molecular mechanisms research
- Cellular Mechanics and Interactions
- MicroRNA in disease regulation
- Cancer Cells and Metastasis
- RNA modifications and cancer
- Fibroblast Growth Factor Research
- Acute Myeloid Leukemia Research
- Mitochondrial Function and Pathology
- Diet, Metabolism, and Disease
- Oral and Maxillofacial Pathology
- Pancreatic function and diabetes
- Neuroinflammation and Neurodegeneration Mechanisms
- Hippo pathway signaling and YAP/TAZ
- Cell death mechanisms and regulation
- Estrogen and related hormone effects
- Cancer-related gene regulation
- Protein Tyrosine Phosphatases
- Stress Responses and Cortisol
- Immunodeficiency and Autoimmune Disorders
- Tryptophan and brain disorders
University of Helsinki
2015-2025
The ChREBP/Mondo-Mlx transcription factors are activated by sugars and essential for sugar tolerance. They promote the conversion of to lipids, but beyond this, their physiological roles insufficiently understood. Here, we demonstrate that in an organism-wide setting Drosophila, Mondo-Mlx controls majority sugar-regulated genes involved nutrient digestion transport as well carbohydrate, amino acid, lipid metabolism. Furthermore, human orthologs targets display enrichment among gene variants...
Breast cancer is now globally the most frequent and leading cause of women's death. Two thirds breast cancers express luminal estrogen receptor-positive (ERα + ) phenotype that initially responsive to antihormonal therapies, but drug resistance emerges. A major barrier understanding ERα-pathway biology therapeutic discoveries restricted repertoire ERα models. The not stable in cultured cells for reasons fully understood. We examine 400 patient-derived epithelial explant cultures (PDECs)...
Diversity in the structure and expression of microRNAs, important regulators gene expression, arises from SNPs, duplications followed by divergence, production isomiRs, RNA editing. Inbred mouse strains crosses using them are reference populations for genetic mapping, as models human disease. We determined nature extent interstrain miRNA variation (i) identifying SNPs whole-genome sequence data 36 strains, (ii) examining editing hippocampus (Hpc) frontal cortex (FCx) six to facilitate study...
Head and neck squamous cell carcinoma (HNSCC) is a heterogeneous group of tumors that derive from the mucosal epithelium upper aerodigestive tract present high mortality rate. Lack efficient targeted-therapies biomarkers towards patients’ stratification are caveats in disease treatment. Anoctamin 1 (ANO1) gene amplified 30% HNSCC cases. Evidence suggests involvement ANO1 proliferation, migration, evasion apoptosis; however, exact mechanisms remain elusive. Aim this study was to unravel...
Abstract Background MAPK/ERK signaling is a well-known mediator of extracellular stimuli controlling intracellular responses to growth factors and mechanical cues. The critical requirement for embryonic stem cell maintenance demonstrated, but specific functions in progenitor regulation during development, particular kidney development remain largely unexplored. We previously demonstrated as key regulator through branching morphogenesis normal nephrogenesis where it also regulates expansion....
Anxiety is an evolutionarily conserved response that essential for survival. Pathological anxiety, however, a maladaptive to nonthreatening situations and greatly affects quality of life. The recent COVID-19 pandemic has increased the prevalence anxiety symptoms highlighted urge identify molecular events initiate pathological anxiety. To this aim, we investigated extent similarity brain region-specific gene expression patterns associated with innate stress-induced anxiety-like behavior. We...
PTPRF interacting protein alpha 1 ( PPFIA1 ) encodes for liprin‐α1, a member of the leukocyte common antigen–related tyrosine phosphatase (LAR‐RPTPs)‐interacting family. Liprin‐α1 localizes to adhesive and invasive structures in periphery cancer cells, where it modulates migration invasion head neck squamous cell carcinoma (HNSCC) breast cancer. To study possible role liprin‐α1 anticancer drug responses, we screened library oncology compounds lines with high endogenous expression. The...