A5042032832- Lung Cancer Treatments and Mutations
- Head and Neck Cancer Studies
- RNA modifications and cancer
- Cancer Cells and Metastasis
- Cell Adhesion Molecules Research
- Molecular Biology Techniques and Applications
- Synthesis and biological activity
- interferon and immune responses
- Plant Disease Resistance and Genetics
- Peptidase Inhibition and Analysis
- Cancer-related Molecular Pathways
- Synthesis and Biological Evaluation
- Cellular Mechanics and Interactions
- Metal complexes synthesis and properties
- Cancer Mechanisms and Therapy
- Telomeres, Telomerase, and Senescence
- Cancer-related gene regulation
- Cancer-related molecular mechanisms research
- Cancer and Skin Lesions
- Oral and Maxillofacial Pathology
- Cancer Research and Treatments
- Cancer and biochemical research
- Lung Cancer Research Studies
- Ubiquitin and proteasome pathways
- Biological Research and Disease Studies
University of Helsinki
2011-2024
Abstract There is an unmet need for effective targeted therapies patients with advanced head and neck squamous cell carcinoma (HNSCC). We correlated gene expression, copy numbers, point mutations in 45 human papillomavirus–negative HNSCC lines the sensitivity to 220 anticancer drugs discover predictive associations genetic alterations. The drug response profiles revealed diverse efficacy of tested across lines. Several genomic abnormalities expression differences were associated mTOR, MEK,...
In vitro cancer drug testing carries a low predictive value. We developed the human leiomyoma–derived matrix “Myogel” to better mimic tumor microenvironment (TME). hypothesized that Myogel could provide an appropriate for cells, thereby allowing more in vivo–relevant testing. screened 19 anticancer compounds, targeting epidermal growth factor receptor (EGFR), MEK, and PI3K/mTOR on 12 head neck squamous cell carcinoma (HNSCC) lines cultured plastic, mouse sarcoma–derived Matrigel (MSDM),...
Abstract PPFIA1 is located at the 11q13 region, which one of most commonly amplified regions in several epithelial cancers including head and neck squamous cell carcinoma breast carcinoma. Considering location this amplicon, we examined whether protein encoded by , liprin-α1, possesses oncogenic properties relevant lines. Our results indicate that liprin-α1 localizes to different adhesion cytoskeletal structures regulate vimentin intermediate filament network, thereby altering invasion...
Oncoproteomics aims to the discovery of molecular markers, drug targets and pathways by studying cancer specific protein expression, localization, modification interaction. Cell surface proteins play a central role in several pathological conditions, including its metastatic spread. However, cell are underrepresented proteomics analyses performed from whole extracts due their hydrophobicity low abundance. Different methods have been developed enrich isolate reduce sample complexity. Despite...
Head and neck squamous cell carcinoma (HNSCC) is a heterogeneous group of tumors that derive from the mucosal epithelium upper aerodigestive tract present high mortality rate. Lack efficient targeted-therapies biomarkers towards patients’ stratification are caveats in disease treatment. Anoctamin 1 (ANO1) gene amplified 30% HNSCC cases. Evidence suggests involvement ANO1 proliferation, migration, evasion apoptosis; however, exact mechanisms remain elusive. Aim this study was to unravel...
PTPRF interacting protein alpha 1 ( PPFIA1 ) encodes for liprin‐α1, a member of the leukocyte common antigen–related tyrosine phosphatase (LAR‐RPTPs)‐interacting family. Liprin‐α1 localizes to adhesive and invasive structures in periphery cancer cells, where it modulates migration invasion head neck squamous cell carcinoma (HNSCC) breast cancer. To study possible role liprin‐α1 anticancer drug responses, we screened library oncology compounds lines with high endogenous expression. The...
<p>Figure S1. Heat map of drug responses 220 compounds across 45 HPV negative cell lines. Figure S2. DSS scores and grouping the used drugs based on their functional categories. S3. An effect transient knock-down RAB25 FAM83H to cellular response EGFR inhibitors afatinib erlotinib.</p>
<div>Abstract<p>There is an unmet need for effective targeted therapies patients with advanced head and neck squamous cell carcinoma (HNSCC). We correlated gene expression, copy numbers, point mutations in 45 human papillomavirus–negative HNSCC lines the sensitivity to 220 anticancer drugs discover predictive associations genetic alterations. The drug response profiles revealed diverse efficacy of tested across lines. Several genomic abnormalities expression differences were...
<p>Figure S1. Heat map of drug responses 220 compounds across 45 HPV negative cell lines. Figure S2. DSS scores and grouping the used drugs based on their functional categories. S3. An effect transient knock-down RAB25 FAM83H to cellular response EGFR inhibitors afatinib erlotinib.</p>
Liprin-α1 is a scaffold protein involved in cell adhesion, motility, and invasion malignancies. inhibits the expression of metastatic suppressor CD82 cancers such as oral carcinoma, these proteins has been known to correlate negatively. The role not previously studied human papillomavirus (HPV)-related head neck cancers. Our aim was assess clinical prognostic liprin-α1 HPV-positive oropharyngeal squamous carcinoma (OPSCC) comparison HPV-negative OPSCC. data included 139 OPSCC patients...
<div>Abstract<p>There is an unmet need for effective targeted therapies patients with advanced head and neck squamous cell carcinoma (HNSCC). We correlated gene expression, copy numbers, point mutations in 45 human papillomavirus–negative HNSCC lines the sensitivity to 220 anticancer drugs discover predictive associations genetic alterations. The drug response profiles revealed diverse efficacy of tested across lines. Several genomic abnormalities expression differences were...