A5010110605- Cell Adhesion Molecules Research
- RNA Research and Splicing
- RNA modifications and cancer
- Caveolin-1 and cellular processes
- Cancer-related gene regulation
- Cancer-related molecular mechanisms research
- Skin and Cellular Biology Research
- Head and Neck Cancer Studies
- Cellular Mechanics and Interactions
- Advanced Proteomics Techniques and Applications
- Monoclonal and Polyclonal Antibodies Research
- Developmental Biology and Gene Regulation
- Genomics and Chromatin Dynamics
- Platelet Disorders and Treatments
- Radiopharmaceutical Chemistry and Applications
- Protein Kinase Regulation and GTPase Signaling
- Chemical Synthesis and Analysis
- Cancer Research and Treatments
- Cancer Genomics and Diagnostics
- Protein Tyrosine Phosphatases
- Kruppel-like factors research
- MicroRNA in disease regulation
- Peptidase Inhibition and Analysis
- Boron Compounds in Chemistry
- Ubiquitin and proteasome pathways
University of Helsinki
2011-2024
Monash University
2012
Institute for Molecular Medicine Finland
2011
HOXB7 encodes a transcription factor that is overexpressed in number of cancers and encompasses many oncogenic functions. Previous results have shown it to promote cell proliferation, angiogenesis, epithelial–mesenchymal transition, DNA repair survival. Because its role tumorigenic processes, has been suggested be potential drug target. However, binding sites on chromatin targets are poorly known. The aim our study was identify breast cancer delineate direct target genes located nearby these...
Abstract PPFIA1 is located at the 11q13 region, which one of most commonly amplified regions in several epithelial cancers including head and neck squamous cell carcinoma breast carcinoma. Considering location this amplicon, we examined whether protein encoded by , liprin-α1, possesses oncogenic properties relevant lines. Our results indicate that liprin-α1 localizes to different adhesion cytoskeletal structures regulate vimentin intermediate filament network, thereby altering invasion...
PPFIA1 is located at the 11q13 region commonly amplified in cancer. The protein liprin-α1 encoded by PPF1A1 contributes to adhesive and invasive structures of cytoskeletal elements invadosomes cancer cells. However, precise mechanism function progression has remained elusive. Invasion regulating activity was examined analyzing functions squamous cell carcinoma head neck (HNSCC) lines three-dimensional collagen I after RNAi mediated gene knockdown. Transcriptome profiling Gene Set Enrichment...
Head and neck squamous cell carcinoma (HNSCC) is a heterogeneous group of tumors that derive from the mucosal epithelium upper aerodigestive tract present high mortality rate. Lack efficient targeted-therapies biomarkers towards patients’ stratification are caveats in disease treatment. Anoctamin 1 (ANO1) gene amplified 30% HNSCC cases. Evidence suggests involvement ANO1 proliferation, migration, evasion apoptosis; however, exact mechanisms remain elusive. Aim this study was to unravel...
PTPRF interacting protein alpha 1 ( PPFIA1 ) encodes for liprin‐α1, a member of the leukocyte common antigen–related tyrosine phosphatase (LAR‐RPTPs)‐interacting family. Liprin‐α1 localizes to adhesive and invasive structures in periphery cancer cells, where it modulates migration invasion head neck squamous cell carcinoma (HNSCC) breast cancer. To study possible role liprin‐α1 anticancer drug responses, we screened library oncology compounds lines with high endogenous expression. The...
This research investigates boronated tryptophans as potential boron delivery agents for neutron capture therapy (BNCT) of cancer. We synthesized both enantiomers 5- and 6-boronotryptophans (1a 1b) using simple inexpensive methods. Their uptake was assessed in two human cancer cell lines, CAL27 (head neck cancer) U87-MG (brain cancer), compared to l-p-boronophenylalanine (l-BPA) a reference. To determine whether these tryptophan derivatives are substrates large amino acid transporter 1, we...
Abstract PPFIA1 (liprin α1) is a member of the liprin (LAR protein-tyrosine phosphatase-interacting protein) family and located at 11q13 amplification region, which one most common amplicons in multiple epithelial cancers. In squamous cell carcinoma head neck (HNSCC), this occurs 30-50% cases. cancers, size structure amplicon complex consists cores that differ between different tumor types. HNSCC, core contains 10 genes are amplified cases with amplification. This region well-established...
Abstract Gene amplification is one of the most common mechanisms for oncogenic activation in human cancer. Some genomic regions are more frequently amplified than others. For example, 11q13 occurs at high frequencies several cancers, such as lung, bladder, breast and ovarian carcinomas, well head neck squamous cell carcinoma (HNSCC). Approximately 40% HNSCC affected by this specific amplification, which associated with presence lymph node metastasis poor prognosis. Distinct core areas within...
Liprin-α1 is a scaffold protein involved in cell adhesion, motility, and invasion malignancies. inhibits the expression of metastatic suppressor CD82 cancers such as oral carcinoma, these proteins has been known to correlate negatively. The role not previously studied human papillomavirus (HPV)-related head neck cancers. Our aim was assess clinical prognostic liprin-α1 HPV-positive oropharyngeal squamous carcinoma (OPSCC) comparison HPV-negative OPSCC. data included 139 OPSCC patients...