A5006214532- Diabetes and associated disorders
- Anorectal Disease Treatments and Outcomes
- Ferroptosis and cancer prognosis
- Endometrial and Cervical Cancer Treatments
- Ovarian cancer diagnosis and treatment
- Radiomics and Machine Learning in Medical Imaging
- Pancreatic function and diabetes
- Diverticular Disease and Complications
- Renal cell carcinoma treatment
- Cervical Cancer and HPV Research
- Cancer Genomics and Diagnostics
- Cancer-related molecular mechanisms research
- Diabetes Management and Research
- Congenital gastrointestinal and neural anomalies
- Bioinformatics and Genomic Networks
- Immune Cell Function and Interaction
- Appendicitis Diagnosis and Management
- Heart Rate Variability and Autonomic Control
- Glycosylation and Glycoproteins Research
- Molecular Biology Techniques and Applications
- Glioma Diagnosis and Treatment
- Diabetes Treatment and Management
- Adipokines, Inflammation, and Metabolic Diseases
- Biliary and Gastrointestinal Fistulas
- Gallbladder and Bile Duct Disorders
University of Arizona
2024
Augusta University
2018-2023
Yale University
2022-2023
Children's Hospital Colorado
2023
University of Colorado Denver
2023
Center for Genomic Science
2021-2022
Augusta University Health
2019-2021
Eastern Virginia Medical School
2009
University of Nebraska Medical Center
2009
Chronic low-grade inflammation is involved in the pathogenesis of type-1 diabetes (T1D) and its complications. In this cross-section study design, we investigated association between serum levels soluble cytokine receptors with presence peripheral neuropathy 694 patients. Sex, age, blood pressure, smoking, alcohol intake, HbA1c lipid profile, DPN (peripheral autonomic), retinopathy nephropathy was obtained from patient’s chart. Measurement receptors, markers systemic vascular done using...
Larning Objectives: The reader is presumed to have a broad understanding of aesthetic surgical procedures. After studying this article, the participant should be able to:
Molecular biomarkers that can predict survival and therapeutic outcome are still lacking for cervical cancer. Here we measured a panel of 19 serum proteins in sera from 565 patients with stage II or III cancer identified 10 have an impact on disease specific (DSS) (Hazzard’s ratio; HR = 1.51–2.1). Surprisingly, all ten implicated senescence-associated secreted phenotype (SASP), hallmark cellular senescence. Machine learning using Ridge regression these SASP robustly stratify high SASP, which...
Publicly available gene expression datasets were analyzed to develop a chromophobe and oncocytoma related signature (COGS) distinguish chRCC from RO. The GSE11151, GSE19982, GSE2109, GSE8271 GSE11024 combined into discovery dataset. transcriptomic differences identified with unsupervised learning in the dataset (97.8% accuracy) density based UMAP (DBU). top 30 genes by univariate analysis ROC analysis, create called COGS. COGS, DBU, was able differentiate RO an accuracy of 97.8%....
Abstract Gliomas are currently classified through integration of histology and mutation information, with new developments in DNA methylation classification. However, discrepancies exist amongst the major classification methods. This study sought to compare transcriptome-based established RNAseq microarray data were obtained for 1032 gliomas from TCGA 395 REMBRANDT. Data analyzed using unsupervised supervised learning other statistical Global transcriptomic profiles defined four glioma...
Abstract Background Chronic uncontrolled hyperglycemia, a precursor to chronic low‐grade inflammation, is leading cause of coronary artery disease (CAD) due plaque buildup in type‐1 diabetes (T1D) patients. We evaluated levels 22 inflammatory markers cross‐sectional serum samples from 1222 subjects evaluate their potential as risk factors for CAD T1D Hypothesis Circulating inflammation may be the incident CAD. Methods The were divided into two groups: those without ( n = 1107) and with 115)....
Gene expression profiling has been shown to be comparable other molecular methods for glioma classification. We sought validate a gene-expression based classification method. Formalin-fixed paraffin embedded tissue and flash frozen collected at the Augusta University (AU) Pathology Department between 2000–2019 were identified 2 mm cores taken. The RNA was extracted from these after deparaffinization bead homogenization. One hundred sixty-eight genes evaluated in samples on nCounter...
The purpose of this study was to model the damage sustained by healthcare campus, in aftermath a hurricane, as tool facilitate pre- and post-storm planning for provision services or campus evacuation. Using HAZUS analysis estimating disaster associated losses, storm surge, residual flooding, wind were modeled hurricane categories 1 thru 5. ability deliver assessed function functional infrastructure. Implications peristorm developed. A Category 2 surge 6 8 feet would completely isolate flood...
Malignant chromophobe renal cancer (chRCC) and benign oncocytoma (RO) are two tumor types difficult to differentiate using histology immunohistochemistry-based methods because of their similarity in appearance. We previously developed a transcriptomics-based classification pipeline with “Chromophobe-Oncocytoma Gene Signature” (COGS) on single-molecule counting platform. Renal patients (n = 32, chRCC 17, RO 15) were recruited from Augusta University Medical Center (AUMC). Formalin-fixed...
Type 1 diabetes (T1D) is an autoimmune disease, characterized by the presence of autoantibodies to protein and non-protein antigens. Here we report identification specific anti-carbohydrate antibodies (ACAs) that are associated with pathogenesis progression T1D. We compare circulatory levels ACAs against 202 glycans in a cross-sectional cohort T1D patients (n = 278) healthy controls 298), as well longitudinal 112). identify 11 clusters glycan function class. Clusters enriched for...
Campylobacter jejuni CsrA is an mRNA-binding, post-transcriptional regulator that controls many metabolic- and virulence-related characteristics of this important pathogen. In contrast to E. coli CsrA, whose activity modulated by binding small non-coding RNAs (sRNAs), C. controlled the antagonist FliW. study, we identified FliW site on CsrA. Deletion C-terminus which extended relative sRNA-binding proteins, abrogated binding. Bacterial two-hybrid experiments were used assess interaction with...
Multiple cross-sectional and longitudinal studies have shown that serum levels of the chemokine ligand 2 (CCL-2) are associated with type 1 diabetes (T1D), although direction effect differs. We assessed CCL-2 in a cohort to clarify this association, combined genetic data elucidate regulatory role T1D pathogenesis. The Diabetes Autoimmunity Study Young (DAISY) followed 310 subjects high risk developing T1D. Of these, 42 became persistently seropositive for islet autoantibodies but did not...
Development of complications in type 1 diabetes patients can be reduced by modifying risk factors. We used a cross-sectional cohort 1646 diagnosed with (T1D) to develop clinical score for diabetic peripheral neuropathy (DPN), autonomic (AN), retinopathy (DR), and nephropathy (DN). Of these patients, 199 (12.1%) had DPN, 63 (3.8%) AN, 244 (14.9%) DR, 88 (5.4%) DN. selected five variables include each the four microvascular models: age, age T1D diagnosis, duration T1D, average systolic blood...
Pediatric advanced endoscopy consists primarily of endoscopic retrograde cholangiopancreatography (ERCP) and ultrasound (EUS) is becoming more common in pediatrics. This study aims to characterize the current landscape pediatric training practice by directly surveying independently practicing endoscopists (PAEs). We also aim ascertain expert opinion on competency ERCP EUS.A 66-question REDCap survey a 73-question Qualtrics were distributed members Special Interest Group North American...
Abstract Malignant chromophobe renal cancer (chRCC) and benign oncocytoma (RO) are two tumor types difficult to differentiate using histology immunohistochemistry-based methods because of their similarity in appearance. We previously developed a transcriptomics-based classification pipeline with “ Chromophobe-Oncocytoma Gene Signature” (COGS) on single-molecule counting platform. Renal patients (n=32, chRCC=17, RO=15) were recruited from Augusta University Medical Center (AUMC)....