The technology of 3D printing offers a customizable manufacturing method, while decreasing material waste. sustainability this industry is important as it grows into more role in the market. use and development recyclable, biodegradable, sustainably sourced materials for extrusion‐based may allow decrease environmental impacts demonstrate importance sustainable method manufacturing. goal article to provide an insight state printing, such cellulose‐based feedstock.

Abstract C. trachomatis is the most common sexually transmitted bacterial infection in world. Although can be easily controlled by use of antibiotics, several reports clinical isolates that are resistant to antibiotics have prompted us search for alternative strategies manage this disease. In paper, we developed a nanoparticle formulation (PDGFR-β siRNA-PEI-PLGA-PEG NP) simultaneously induce autophagy human cells and knock down PDGFR-β gene expression, an important surface binding protein...

Abstract: Hydroxychloroquine (HCQ) has been shown to demonstrate anti-­inflammatory properties and direct anti-HIV activity. In this study, we describe for the first time fabrication in vitro evaluation of two types intravaginal ring (IVR) devices (a surfaced-modified matrix IVR a reservoir segmental IVR) achieving sustained delivery (>14 days) HCQ as strategy preventing male-to-female transmission HIV. Both IVRs were fabricated by hot-melt injection molding. Surface-modified with...

Abstract We designed and engineered novel intravaginal ring (IVR) medical devices via fused deposition modeling (FDM) three-dimensional (3D) printing for controlled delivery of hydroxychloroquine, IgG, gp120 fragment (encompassing the CD4 binding site), coumarin 6 PLGA-PEG nanoparticles (C6NP). The hydrophilic polyurethanes were utilized to 3D-print reservoir-type IVRs containing a tunable release controlling membrane (RCM) with varying thickness adaptable micro porous structures (by...

The use of polymeric devices for controlled sustained delivery drugs is a promising approach the prevention HIV-1 infection. Unfortunately, certain microbicides, when topically applied vaginally, may be cytotoxic to vaginal epithelial cells and protective microflora present within female genital tract. In this study, we evaluated impact hydroxychloroquine (HCQ)-loaded, reservoir-type, polyurethane intravaginal rings (IVRs) on growth Lactobacillus crispatus jensenii viability ectocervical...

Additive manufacturing, commonly referred to as three-dimensional (3D) printing, has the potential initiate a paradigm shift in field of medicine and drug delivery. Ever since advent first-ever United States Food Drug Administration (US FDA)-approved 3D printed tablet, there been an increased interest application this technology delivery biomedical applications. printing brings us one step closer personalized medicine, hence rendering “one size fits all” concept dosing obsolete. In review...

In this study, we investigated the viscoelastic and mechanical behaviour of polyvinyl alcohol films formulated along with carrageenan, plasticizing agents (polyethylene glycol glycerol), when loaded nanoparticles as a model for potential applications microbicides. The storage modulus, loss modulus glass transition temperature were determined using dynamic analyzer. Films fabricated from 2% to 5% containing 3 mg or 5 fluorescently labeled evaluated. values blank shown be higher than...

To achieve a pH-responsive switchable on-demand release of nanoparticles (NPs) from intravaginal rings (IVR), new pH-sensitive polyurethane (PU) bearing dimethylolpropionic acid (PEG-DMPA-HDI-PG) was synthesized to encapsulate NPs as physically cross-linked hydrogel within segmented reservoir-IVR. A PEGylated polyaspartic acid-based copolymer conjugated with the fluorescent dye Orange II (PASP-PEG-Ph-Orange) self-assemble in aqueous solution into (251-283 nm) for study. Chemical structures...

New amphiphilic PEGylated poly(aspartic acid) graft copolymer (PASP-PEG-Ph) was synthesized as a nanocarrier for intravaginal drug delivery of poorly water-soluble drugs. PASP-PEG-Ph self-assembled into negatively charged spherically shaped nanoparticles in the presence pH 4.5 and 7.0 vaginal fluid simulants with diameter approximately 200 nm evidenced by Zeta-potentiometer, scanning electron microscope (SEM), dynamic light scattering (DLS) analysis. A significant number stable NPs could be...

Acquired superficial fungal infections are among the most common infections. It is necessary to create new effective and non-toxic disinfectants. AKWATON a disinfectant of polymeric guanidine family. Its fungicidal activity against Trichophyton mentagrophytes its in vitro toxicity assessment were determined this study. The MIC, minimum concentration (MFC) time required for at MFC evaluated using official methods analysis Association Official Analytical Chemists, with modifications as...

Abstract Vaginal drug delivery has been shown to be a promising strategy for the prevention of sexually transmitted infections. Therapy delivered at site infection many advantages including improved therapeutic efficacy, reduction in systemic toxicity, and reduced potential development resistance. We developed “smart” combination intravaginal ring (IVR) that will (1) provide continuous release hydroxychloroquine (HCQ) induce T cell immune quiescence as first-line defense (2) nanoparticles...