A5102851715- RNA Interference and Gene Delivery
- Reproductive tract infections research
- Advanced Drug Delivery Systems
- HIV Research and Treatment
- Reproductive System and Pregnancy
- Immunotherapy and Immune Responses
- Cell Adhesion Molecules Research
- Protein purification and stability
- Quantum Dots Synthesis And Properties
- Extracellular vesicles in disease
- Monoclonal and Polyclonal Antibodies Research
- Probiotics and Fermented Foods
- Antimicrobial Peptides and Activities
- Herpesvirus Infections and Treatments
- COVID-19 Impact on Reproduction
- HIV/AIDS drug development and treatment
- Adolescent Sexual and Reproductive Health
- Sex work and related issues
- Gut microbiota and health
- T-cell and B-cell Immunology
- Sexual function and dysfunction studies
University of Manitoba
2013-2024
University of Waterloo
2018-2024
The goal of this study was to develop and characterize a novel intravaginal film platform for targeted delivery small interfering RNA (siRNA)-loaded nanoparticles (NP) dendritic cells as potential gene therapy the prevention sexually transmitted human immunodeficiency virus (HIV) infection. Poly(ethylene glycol) (PEG)-functionalized poly(D, L-lactic-co-glycolic acid) (PLGA)/polyethylenimine (PEI)/siRNA NP (siRNA-NP) were fabricated using modified emulsion-solvent evaporation method...
Abstract: The goal of this study was to develop and characterize an intravaginal nanomedicine for the active targeted delivery saquinavir (SQV) CD4 + immune cells as a potential strategy prevent or reduce HIV infection. formulated into vaginal gel provide ease in self-administration enhance retention within tract. SQV-encapsulated nanoparticles (SQV-NPs) were prepared from poly(lactic- co -glycolic acid)(PLGA) conjugated antihuman anti-CD4 antibody. Antibody-conjugated SQV-NPs (Ab-SQV-NPs)...
Abstract C. trachomatis is the most common sexually transmitted bacterial infection in world. Although can be easily controlled by use of antibiotics, several reports clinical isolates that are resistant to antibiotics have prompted us search for alternative strategies manage this disease. In paper, we developed a nanoparticle formulation (PDGFR-β siRNA-PEI-PLGA-PEG NP) simultaneously induce autophagy human cells and knock down PDGFR-β gene expression, an important surface binding protein...
Abstract We designed and engineered novel intravaginal ring (IVR) medical devices via fused deposition modeling (FDM) three-dimensional (3D) printing for controlled delivery of hydroxychloroquine, IgG, gp120 fragment (encompassing the CD4 binding site), coumarin 6 PLGA-PEG nanoparticles (C6NP). The hydrophilic polyurethanes were utilized to 3D-print reservoir-type IVRs containing a tunable release controlling membrane (RCM) with varying thickness adaptable micro porous structures (by...
Anti-α 4 β 7 monoclonal antibody–conjugated nanoparticles block integrin α on intravaginal T cells in rhesus macaques.
Recently, a growing number of macromolecules such as peptides and proteins have been formulated into various microbicide formulations for the prevention sexually transmitted infections. However, fast reliable high-throughput method quantitating peptide/protein in polymer-based is still lacking. As result, we developed validated reversed-phase high-performance liquid chromatography quantitation gp120 fragment LL-37 simultaneously gel formulations. This was capable detecting limit linearity...