A5011586388- Marine and coastal ecosystems
- Microbial Community Ecology and Physiology
- Marine Biology and Ecology Research
- Antibiotic Resistance in Bacteria
- Protist diversity and phylogeny
- CRISPR and Genetic Engineering
- Mycobacterium research and diagnosis
- RNA and protein synthesis mechanisms
- Advanced biosensing and bioanalysis techniques
- Coastal wetland ecosystem dynamics
- Gut microbiota and health
- Geochemistry and Elemental Analysis
- Probiotics and Fermented Foods
- Isotope Analysis in Ecology
- Marine and coastal plant biology
- Atmospheric chemistry and aerosols
- Wastewater Treatment and Nitrogen Removal
- Syphilis Diagnosis and Treatment
- Reproductive tract infections research
- Pharmaceutical and Antibiotic Environmental Impacts
- Pneumocystis jirovecii pneumonia detection and treatment
- Virology and Viral Diseases
- Streptococcal Infections and Treatments
- Milk Quality and Mastitis in Dairy Cows
- Neonatal and Maternal Infections
Statens Serum Institut
2023-2025
University of Copenhagen
2013-2024
A highly virulent sub-lineage of the Streptococcus pyogenes M1 clone has been rapidly expanding throughout Denmark since late 2022 and now accounts for 30% new invasive group streptococcal infections. We aimed to investigate whether a shift in variant composition can account high incidence rates observed over winter 2022/23, or if these are better explained by impact COVID-19-related restrictions on population immunity carriage .
Background The war in Ukraine led to migration of Ukrainian people. Early 2022, several European national surveillance systems detected multidrug-resistant (MDR) bacteria related patients. Aim To investigate the genomic epidemiology New Delhi metallo-β-lactamase (NDM)-producing Providencia stuartii from patients among countries. Methods Whole-genome sequencing 66 isolates sampled 2022–2023 10 countries enabled whole-genome multilocus sequence typing (wgMLST), identification resistance genes,...
Background/Objectives: Fosfomycin, a critically important antibiotic, is widely used to treat urinary tract infections (UTIs) caused by multidrug-resistant (MDR) Escherichia coli, particularly those producing extended-spectrum β-lactamases (ESBLs). However, its increasing use in livestock has raised concerns about resistance development and global dissemination. This study investigated fosfomycin E. coli isolates from 400 fecal samples collected at Brazilian broiler farms. Methods: The were...
The CRISPR (clustered regularly interspaced short palindromic repeats) system protects archaea and bacteria by eliminating nucleic acid invaders in a crRNA-guided manner. Sulfolobus islandicus type III-B Cmr–α targets invading at both RNA DNA levels targeting relies on the directional transcription of protospacer vivo. To gain further insight into involved mechanism, we purified native effector complex from S. characterized it vitro. cleaved RNAs complementary to crRNA present its ssDNA...
A surge in gonorrhoea Denmark has occurred since 2022, a 46% increase from 2021. National surveillance, leveraging mandatory reporting and epidemiological data, highlights three distinct clades linked to heterosexual transmission. Despite the rise, these exhibit high susceptibility, contrasting MSM-associated strains. Geographical hotspots age-specific patterns further illuminate transmission dynamics. The combination of genomic data provides novel insights into evolving landscape...
Bacteria and Archaea encode clustered, regularly interspaced, short palindromic repeat (CRISPR) systems to confer adaptive immunity invasive viruses plasmids. Recent studies of CRISPR revealed that diverse CRISPR-associated (Cas) interference modules often coexist in different organisms but functions cas genes have not been dissected any these systems. The crenarchaeon Sulfolobus islandicus encodes three distinct modules, including a type IA system two IIIB systems: Cmr-α Cmr-β. To study the...
Nitrogen (N2) fixation by heterotrophic non-cyanobacterial diazotrophs is common in marine deep-sea sediments. However, shallow coastal areas, where resuspension of sediments extensive, the magnitude sediment-associated N2 during unknown. We examined nitrogen dark slurry incubations with (0–5 cm and 0–10 depths) under simulated from five stations (water depth <1 m) an anoxic site Bay Gdansk (109 Baltic Sea. Abiotic variables composition fixing organisms (diazotrophs) were measured at study...
Abstract Estuaries receive substantial anthropogenic nitrogen loading and are mainly considered net sinks. While several studies have identified diverse diazotrophic communities in estuarine sediments, the role of pelagic diazotrophs these systems is not well understood. We investigated links between community composition, nitrogenase ( nifH ) gene expression, N 2 fixation, environmental conditions Narragansett Bay (USA). Pelagic fixation rates ranged 0.02 9.41 nmol L −1 d correlated...
Abstract. N2 fixation rates were measured in the 0–1000 m layer at 13 stations located open western and central Mediterranean Sea (MS) during PEACETIME cruise (late spring 2017). While spatial variability was not related to Fe, P nor N stocks, surface composition of diazotrophic community indicated a strong longitudinal gradient increasing eastward for relative abundance non-cyanobacterial diazotrophs (NCDs) (mainly γ-Proteobacteria) conversely decreasing photo-heterotrophic group A (UCYN-A)...
Extraintestinal pathogenic
Seagrasses can enhance nutrient mobilization in their rhizosphere via complex interactions with sediment redox conditions and microbial populations. Yet, limited knowledge exists on how seagrass-derived dynamics affect nitrogen cycling. Using optode gel-sampler-based chemical imaging, we show that radial O2 loss (ROL) from rhizomes roots leads to the formation of gradients around below-ground tissues seagrass (Zostera marina), which are co-localized regions high ammonium concentrations...
Nitrogen (N2) fixation rates in the brackish Baltic Sea are among highest per unit of area world. However, beyond filamentous heterocyst-forming cyanobacteria, knowledge about composition and distribution N2-fixing microbes (diazotrophs) is limited. To address this, we investigated nitrogenase gene (nifH) expression at coastal (<10 km offshore) offshore (>10 stations, surface (avg. 1.8 m) depth 24 free-living (0.2–3 μm) particle-associated size fractions (>3 μm). Surprisingly, nifH genes...
Abstract Linezolid resistance in Enterococcus spp. is increasingly considered critically important and a public health threat which mandates the need to understand their genomic contents dissemination patterns. Here, we used whole-genome sequencing characterize resistome, virulome mobile genetic elements of nine linezolid-resistant (LZD R ) enterococci (seven optrA - E. faecalis, one poxtA faecium casseliflavus previously obtained from nares healthy dogs, pigs, pig farmers tracheal samples...
The contribution of non-cyanobacterial diazotrophs (NCDs) to total N2 fixation in the marine water column is unknown, but their importance likely constrained by limited availability dissolved organic matter and low O2 conditions. Light could support growth NCDs, yet no examples from bacterioplankton exist. In this study, we show that phototrophic NCD, Rhodopseudomonas sp. BAL398, which a member diazotrophic community surface waters Baltic Sea, can utilize light. Our study highlights...
Abstract Background Linezolid resistance in Enterococcus faecalis (a normal gut bacterium) is increasingly considered a critical public health concern, hence the need to understand their genomic contents and dissemination patterns. Methods Illumina-based sequencing was used characterize seven linezolid-resistant (LZDR) E. strains obtained from nares of healthy humans animals Spain. Also, relatedness with publicly available genomes similar lineages AMR determinants accessed by core-genome SNP...
A panaritium developed in a woman Demark after her cat scratched her. Analysis of tissue by 16S rRNA gene sequencing revealed Mycoplasma phocimorsus, known to cause seal finger. The source the bacterium likely transmitted is unknown, but awareness potential zoonotic transmission from cats should be raised.
Abstract. N2 fixation rates were measured in the 0–1000 m layer at 13 stations located open western and central Mediterranean Sea (MS) during PEACETIME cruise (late spring 2017). While spatial variability of was not related to Fe, P nor N stocks, surface composition diazotrophic community indicated a strong eastward increasing longitudinal gradient for relative abundance non-cyanobacterial diazotrophs (NCD) (mainly γ-Proteobacteria) conversely decreasing UCYN-A -A1 -A3) as did rates. UCYN-A4...