A5082082576- Sulfur-Based Synthesis Techniques
- Chemical Synthesis and Reactions
- Catalytic C–H Functionalization Methods
- Synthesis and Catalytic Reactions
- Click Chemistry and Applications
- Multicomponent Synthesis of Heterocycles
- Nanocluster Synthesis and Applications
- Advanced biosensing and bioanalysis techniques
- Nanomaterials for catalytic reactions
- Synthesis and biological activity
- Studies on Chitinases and Chitosanases
- Catalytic Cross-Coupling Reactions
- Synthesis and Biological Evaluation
- Cholinesterase and Neurodegenerative Diseases
- Oxidative Organic Chemistry Reactions
- Enzyme Production and Characterization
- Phytase and its Applications
- Protein Hydrolysis and Bioactive Peptides
- Advanced Nanomaterials in Catalysis
- Synthesis of Organic Compounds
- Urinary Bladder and Prostate Research
- Moringa oleifera research and applications
- Electrochemical sensors and biosensors
- Carbon and Quantum Dots Applications
- Organoselenium and organotellurium chemistry
Shoolini University
2023-2025
Panjab University
2020-2024
Abdul Wali Khan University Mardan
2022-2024
Delhi Pharmaceutical Science and Research University
2024
Central Drug Research Institute
2014-2023
University of Lahore
2023
National Institute of Pharmaceutical Education and Research
2018-2023
Betsi Cadwaladr University Health Board
2023
Council of Scientific and Industrial Research
2011-2022
Academy of Scientific and Innovative Research
2015-2022
Chitin is one of the most abundant biopolymers widely distributed in marine and terrestrial environments. Chitinase enzyme has received increased attention due to its wide range biotechnological applications, especially agriculture for biocontrol phytopathogenic fungi harmful insects. In present study, 58 bacterial isolates were screened chitinolytic activity on basis chitin hydrolysis zone 6 selected chitinase production broth media. Based production, two potent identified as Aeromonas...
Novel stilbene–chalcone (S-C) hybrids were synthesized via a sequential Claisen–Schmidt–Knoevenagel–Heck approach and evaluated for antiplasmodial activity in vitro red cell culture using SYBR Green I assay. The most potent hybrid (11) showed IC50 of 2.2, 1.4, 6.4 μM against 3D7 (chloroquine sensitive), Indo, Dd2 resistant) strains Plasmodium falciparum, respectively. Interestingly, the respective individual stilbene (IC50 > 100 μM), chalcone = 11.5 or an equimolar mixture 32.5 μM) less than...
Bovine serum albumin–iodine acts as a cooperative catalyst for C(sp<sup>2</sup>)–H sulfenylation of indoles and hydroxyaryls (<italic>i.e.</italic> 2-naphthol/4-hydroxycoumarin) with diverse thiols (aryl/heteroaryl) using water under aerobic conditions.
Abstract Thiol–ene “click” chemistry has emerged as a powerful strategy to construct carbon–heteroatom (CS) bonds, which generally results in the formation of two regioisomers. To this end, neutral ionic liquid [hmim]Br been explored solvent cum catalyst for synthesis linear thioethers from activated and inactivated styrene derivatives or secondary benzyl alcohols thiols without requirement using metal complex, base, free radical initiator. Furthermore, detailed mechanistic investigations 1...
In the present scenario, resistance to antibiotics has become a threatening situation for public health. To find solution this, conjugation of cationic peptide with silver nanoparticles is emerging as promising route attain enhanced antibacterial activity. this direction, work reports synthesis lysine-based (BP100: NH2–KKLFKKILKYL–amide) functionalized (BP100@AgNPs). The interacts electrostatically in an aqueous medium. developed nanosystem followed green chemistry principles, owing use...
Abstract Reduction of nitroarenes was achieved using magnetically separable and reusable iron oxide nanoparticles (Fe 3 O 4 @ RA NPs) Rhododendron arboreum ( ) flower extract with high yields in water hydrazine hydrate as a green hydrogen source. The synthesis the biogenic NPs has been done tools displays excellent magnetic properties, which have proved by vibrating sample magnetometry (VSM). Further, field‐emission scanning electron microscopy (FE‐SEM), Fourier transform infrared...
Bifunctionalized indoles are an important class of biologically active heterocyclic compounds and potential drug candidates. Because the lack efficient synthetic methods, one pot cascade synthesis these is rare remains a challenge. To expand this field, we herein disclose step-economical temperature tunable strategy wherein synergistic effect between [hmim]Br-ArSO2Cl leads exclusively to formation 3-arylthio indole via sulfenylation at room temperature, while heating reaction mixture 50 °C...
Interstitial cystitis (IC) is the principal unwanted effect associated with use of cyclophosphamide (CYP). It results in increased oxidative stress, overexpression proinflammatory cytokines, and bladder overactivity. Patients receiving CYP treatment had severely depreciated quality life, as available not safe effective. The goal this study was to assess protective caftaric acid CYP-induced IC. IC induced female Sprague Dawley by injecting (150 mg/kg, i.p.). In present study, oral...
Apigenin is a phytochemical obtained from Chamomilla recutita. Its role in interstitial cystitis not yet known. The present study aimed at understanding the uroprotective and spasmolytic effects of apigenin cyclophosphamide-induced cystitis. was analyzed by qRT-PCR, macroscopic analysis, Evans blue dye leakage, histological evaluation, molecular docking. response measured adding cumulative concentrations to isolated bladder tissue pre-contracted with KCl (80 mM) carbachol (10-9-10-4) on...
Whole exome sequencing has provided significant opportunities to discover novel candidate genes for intellectual disability and autism spectrum disorders. Variants in the spectrin SPTAN1, SPTBN1, SPTBN2 , SPTBN4 have been associated with neurological disorders; however, SPTBN5 gene-variants not any human disorder. This is first report that associates gene variants (ENSG00000137877: c.266A&gt;C; p.His89Pro, c.9784G&gt;A; p.Glu3262Lys, c.933C&gt;G; p.Tyr311Ter, c.8809A&gt;T;...
Abstract Advancement in nanotechnology paves new way nanomedicine via synthesis of various scaffolds bearing multifunctionalities having characteristics both as diagnostic and therapeutic applications. Quantum dots (QDs) with exceptional luminescent properties exhibited some unbeatable small size ease surface modifications thus make them suitable candidates to be used drug delivery diagnosis diseases. Meanwhile, type peptides are known literature for their excellent promising conjugate...
Abstract Tandem reactions that involve chemoselective Knoevenagel/Perkin condensation–decarboxylation–Heck/Suzuki coupling or Heck–aldol sequences have been achieved. This enabled the first concise and efficient synthesis of several important hydroxy‐functionalized compound classes, such as stilbene–cinnamoyl hybrids (potent protein tyrosine phosphatase1B inhibitors), cinnamoyl–cinnamic acid hybrids, asymmetric distyrylbenzenes, biarylstyrenes. Previously reported require multiple steps...
Abstract In this work, a new strategy to synthesize 3‐sulfenyl/selenyl indole is reported wherein LC−MS reveals novel insight into synergistic cooperative effect of NaBH 4 ‐I 2 which allows cascade C−N and C−S/C−Se bond formations via reduction‐nucleophilic cyclization‐chalcogenylation, three steps in one‐pot, towards regioselective synthesis diverse 3‐chalcogenyl indoles including 5‐bromo‐3‐[(3,4,5‐trimethoxyphenyl)thio]‐1H‐indole, known lead anticancer compound, directly from...
Arginine in conjunction with water has been employed as an effective and recyclable organocatalyst for oxidative coupling of thiophenols hydrothiolation alkynes.
Abstract The reduction of nitro compounds is one the fundamental organic transformations and ascertain wide applicability in industrial chemistry, synthesis valuable scaffolds, fine chemical synthesis, as well environmental for decontamination process. transformation involves conversion into scaffolds including amino, nitroso, hydroxyl amines, azo, hydrazo compounds. Conventional approaches environmentally harmful stoichiometric reagents, high-boiling reaction media, tedious processes, harsh...
A new one-pot strategy has been developed, wherein abundantly available methoxylated phenylpropenes are directly transformed into corresponding dienones (1,5-diarylpenta-2,4-dien-1-ones) and enones (chalcones cinnamic esters) via allylic oxidation-condensation or oxidation-esterification sequences. Preliminary antimalarial activity studies of the above synthesized diaryldienones against Plasmodium falciparum (Pf3D7) have shown them to be promising lead candidates for developing newer...
Abstract Thiol–ene “click” chemistry has emerged as a powerful strategy to construct carbon–heteroatom (CS) bonds, which generally results in the formation of two regioisomers. To this end, neutral ionic liquid [hmim]Br been explored solvent cum catalyst for synthesis linear thioethers from activated and inactivated styrene derivatives or secondary benzyl alcohols thiols without requirement using metal complex, base, free radical initiator. Furthermore, detailed mechanistic investigations 1...