This study investigated the use of pure polymer chitosan (CS), xanthan gum (XG), monomer 2-acrylamido-2-methylpropane sulfonic acid (AMPS) and initiator potassium persulfate (KPS) as drug carrier system crosslinked through N' N'-methylene bis-acrylamide (MBA) for controlled delivery acyclovir (ACV). ACV is highly effective selective antiviral drugs used prophylaxis treatment against herpes simplex viruses (HSV) infections. Present oral marketed formulations are associated with number side...

Abstract A series of sodium alginate‐graft‐poly(acrylic acid) hydrogels (SA‐g‐pAA hydrogels) were synthesized with alginate (SA) and acrylic acid (AA) in aqueous solution, ethylene glycol dimethacrylate (EGDMA) as a cross‐linker ammonium peroxodisulfate (APS) an initiator. Hydrogels evaluated for thermal stability (TGA & DSC), revealing their higher strength toward variation compared to individual components. SEM micrographs show smooth solid outer surface lack porosity on it. FTIR...

Abstract An oral route of administration is a most acceptable for patient, so we designed chemically cross‐linked polyethylene glycol‐co‐poly(methacrylic acid) hydrogels ( PEGMA 4000) by free radical polymerization method pH ‐responsive colon target delivery oxaliplatin OXP ). Polyethylene glycol PEG was with methacrylic acid MAA ) in distilled water. Ammonium peroxodisulfate APS and N, N‐methylene bisacrylamide MBA were used as initiator cross‐linker respectively. loaded prepared hydrogels....

In this work, series of pH-responsive hydrogels (FMA1-FMA9) were synthesized, characterized, and evaluated as potential carrier for oral delivery an antiviral drug, acyclovir (ACV). Different proportions β-cyclodextrin (β-CD), chitosan (CS), methacrylic acid (MAA) N' N'-methylenebis-acrylamide (MBA) used to fabricate

Free-radical polymerization technique was adopted to fabricate a stimuli-responsive intelligent quince/mucin co-poly (methacrylate) hydrogel for the controlled delivery of acyclovir sodium. The developed matrices were appraised using different parameters, such as drug loading (%), swelling kinetics, pH- and electrolyte-responsive swelling, sol–gel fraction. Drug-excipient compatibility study, scanning electron microscopy, thermal analysis, powder X-ray diffraction (PXRD) in vitro release...

Hydrogels with the main objective of releasing mesalamine (5-aminosalicylic acid) in colon a modified manner were formulated present work using free-radical polymerization approach. Different ratios hyaluronic acid cross-linked methacrylic and acrylic acids methylenebis(acrylamide). The development new polymeric network successful loading drug revealed by Fourier transform infrared spectroscopy. Thermogravimetric analysis demonstrated that hydrogel was more thermally stable than pure polymer...

ABSTRACT The purpose of this study was to develop and characterize chemically crosslinked chondroitin sulfate‐ co ‐poly(methacrylic acid) (CSMA) hydrogels for colon targeting oxaliplatin (OXP) treat colorectal cancer. CSMA were synthesized by free‐radical polymerization. Chondroitin sulfate with methacrylic acid in an aqueous medium. Ammonium peroxodisulfate N,N ‐methylene bisacrylamide used as the initiator crosslinker, respectively. Fourier transform infrared spectroscopy,...

The objective of this study was to fabricate and evaluate a pH sensitive cross-linked polymeric network through the free radical polymerization technique for model drug, cyclophosphamide, used in treatment non-Hodgkin’s lymphoma. Hydrogels were prepared using blend agarose, Pluronic acid, glutaraldehyde, methacrylic acid. hydrogels characterized drug loading (%), swelling pattern, release behavior, ingredient’s compatibility, structural evaluation, thermal integrity, toxicity evaluation...

Acyclovir is an antiviral drug that frequently prescribed for the herpes virus. However, requires frequent dosing due to limited bioavailability (10-26.7%). The rationale of present study was develop a self-dissolving microneedle system local and systemic delivery acyclovir using topical lyophilized wafer on microneedle-treated skin provide at site infection. microneedles prepared with hydroxypropyl methylcellulose (HPMC) (8% w/w) or HPMC w/w)-polyvinyl pyrrolidone (PVP) (30% penetrated...

The main objective of the current research work was to synthesize mesoporous silica nanoparticles for controlled delivery mometasone furoate potential nasal delivery. optimized sol-gel method used synthesis nanoparticles. Synthesized were processed through Zeta sizer, SEM, TEM, FTIR, TGA, DSC, XRD, and BET analysis structural characterization. in vitro dissolution test performed inclusion compound, while Franz diffusion experiment permeability formulation. For determination expression levels...

Interstitial cystitis (IC) is the principal unwanted effect associated with use of cyclophosphamide (CYP). It results in increased oxidative stress, overexpression proinflammatory cytokines, and bladder overactivity. Patients receiving CYP treatment had severely depreciated quality life, as available not safe effective. The goal this study was to assess protective caftaric acid CYP-induced IC. IC induced female Sprague Dawley by injecting (150 mg/kg, i.p.). In present study, oral...

Abstract The purpose of current research work was to synthesize and evaluate the cross‐linked ternary hydrogels using polyvinyl alcohol ( PVA ) two monomers itaconic acid methacrylic acid. Controlled combinatorial drug delivery systems CCDDS were synthesized by free radical solution polymerization method ethylene glycol dimethacrylate EGDMA as cross‐linking agent. 5‐Fluorouracil (5‐ FU leucovorin calcium LC loaded in combination into gels for colonic delivery. Various characterizations such...

Research aimed to develop and evaluate biodegradable, pH-responsive chemically cross-linked Pluronic F127 co-poly- (acrylic acid) nanogels for dermal delivery of Terbinafine HCL (TBH) increase its permeability as a new approach treat skin fungal infections. TBH-loaded were successfully synthesized from acrylic acid (AA) by free-radical copolymerization technique using N,N'-methylene bisacrylamide (MBA) crosslinker ammonium persulphate (APS) initiator. Prepared exhibited 93.51% drug...

Objective of the research was to potentiate solubility Rosuvastatin by nanogels synthesized free radical polymerization. Surface morphology and structural compatibility were studied through scanning electron microscopy (SEM) Fourier Transform Infrared (FTIR) spectroscopy. Zeta sizer used for particle size analysis. Swelling, in-vitro release studies accomplished in different media. Similarly, results commercially available tablets compared dissolution Biocompatibility study performed healthy...

This study investigates the anti-inflammatory and immunomodulatory effects of a Benzimidazole derivative 2-((1H-benzo[d]imiadazol-2-yl) thio)-1-3, 5-diphenyl-1h-pyrazol-1-yl)ethanone (BZ), in both chronic acute inflammation models. For induction arthritis, Freund’s Complete Adjuvant was used. After inducing arthritis rats, three different doses benzimidazole (25,50 100 mg/kg) were given. The treatment started on 7th day continued for 3 weeks. Piroxicam used as standard drug. On last...

Cyclophosphamide (CYP)-induced cystitis is a significant clinical challenge in cancer patients, characterized by inflammation, oxidative stress, and muscle dysfunction. This study aimed to investigate the protective effects of lamotrigine cinnamaldehyde silver complex (LCSC) against CYP-induced cystitis. Sprague-Dawley rats were divided into six groups: Control, (Disease Control), mesna (standard drug), three LCSC treatment groups (2.5, 5, 10 mg/kg). Nociception, open-field test, bladder...

Recent study aimed to fabricate pH responsive, intelligent, Pluronic F127 based polymeric system for controlled delivery of Famciclovir. Nine formulations were developed through free radical polymerization. Polymeric exhibited dependent swelling by showing higher degree in simulated intestinal fluid 7.4 while negligible gastric 1.2. Drug loading increased with increase percent water content. Famciclovir was found range 60.892% 73.741%. In FTIR spectra, characteristic peaks achieved...

Poor solubility is a global issue of copious pharmaceutical industries as large number drugs in development stage well already marketed products are poorly soluble which results low dissolution and ultimately dosage increase. Current study aimed at developing polyvinylpyrrolidone- (PVP-K30-) based nanogel delivery system for enhancement drug olanzapine (OLP), solubilization the most noteworthy application nanosystems. Crosslinking polymerization with subsequent condensation technique was...