A5039965685- Advanced Drug Delivery Systems
- Nanoparticle-Based Drug Delivery
- Drug Solubulity and Delivery Systems
- Nanoparticles: synthesis and applications
- Advancements in Transdermal Drug Delivery
- Bone Metabolism and Diseases
- Estrogen and related hormone effects
- Blood groups and transfusion
- Phytoestrogen effects and research
- Analytical Chemistry and Chromatography
- Analytical Methods in Pharmaceuticals
- Bone Tissue Engineering Materials
- Immunodeficiency and Autoimmune Disorders
- Heat shock proteins research
- Anesthesia and Pain Management
- Heavy Metal Exposure and Toxicity
- Chemical Synthesis and Characterization
- Curcumin's Biomedical Applications
- Pharmacological Effects of Natural Compounds
- Hemoglobinopathies and Related Disorders
- Plant Pathogens and Fungal Diseases
- Rangeland and Wildlife Management
- Inorganic and Organometallic Chemistry
- Dendrimers and Hyperbranched Polymers
- Hydrogels: synthesis, properties, applications
Guizhou University
2025
China Agricultural University
2025
University of Maryland Eastern Shore
2023-2025
Combined Military Hospital
2018-2024
Armed Forces Institute of Pathology
2019-2024
Indian Institute of Science Education and Research, Bhopal
2024
Temple University Hospital
2024
University of Veterinary and Animal Sciences
2023-2024
University College for Women
2023
Husson University
2022-2023
Background: Delivery of a high concentration anticancer drugs specifically to cancer cells remains the biggest challenge for treatment multidrug-resistant cancer. Poloxamers and D-α-Tocopheryl polyethylene glycol 1000 succinate (TPGS) are known inhibitors P-glycoprotein (P-gp). Mixed micelles prepared from Poloxamer 407 TPGS may increase therapeutic efficacy drug by delivering concentrations inside inhibiting P-gp. Gambogic acid (GA) is naturally derived novel agent, but poor solubility...
Doxorubicin was intercalated into novel zirconium phosphate nano-platelets (ZrP). The obtained doxorubicin ZrP had an impressive 34.9% (w/w) drug loading. We used this material to deliver breast cancer cells (MCF-7). Cellular studies with MCF-7 showed higher uptake and cytotoxicity of loaded compared free doxorubicin.
Objective: The aim of this study was to investigate the in vitro and vivo performance self-nanoemulsifying drug delivery systems (SNEDDS) talinolol (TAL), a poorly water soluble drug. Method: SNEDDS TAL were prepared using various oils, non-ionic surfactants and/or water-soluble co-solvents assessed visually/by droplet size measurement. Equilibrium solubility anhydrous diluted conducted achieve maximum loading. dissolution experiments human red blood cells (RBC) toxicity test, ex gut...
Formulation and evaluation of mixed polymeric micelles quercetin for treatment breast, ovarian, multidrug resistant cancers Arjun Patra,1,2,* Swaha Satpathy,1,2,* Anitha K Shenoy,1 Jason A Bush,3 Mohsin Kazi,4 Muhammad Delwar Hussain1,* 1College Pharmacy, Department Pharmaceutical Biomedical Sciences, California Health Sciences University, Clovis, CA, USA; 2Institute Guru Ghasidas Vishwavidyalaya, Bilaspur (C.G.), India; 3Department Biology, State Fresno, 4Kayyali Chair Industries, College...
The biggest challenge for the treatment of multidrug resistance cancer is to deliver high concentration anticancer drugs specifically cells longer period time. Poloxamers and D-alpha-Tocopheryl polyethylene glycol 1000 succinate (TPGS) are known inhibitors P-glycoprotein. Mixed micelles prepared from Poloxamer 407 TPGS may increases therapeutic efficacy drug by delivering inside inhibition P-gp. Curcumin (CUR) a naturally derived novel agent but poor solubility limited its clinical use. In...
Exosomes are extracellular vesicles released by almost all cell types, including cancer cells, into bodily fluids such as saliva, plasma, breast milk, semen, urine, cerebrospinal fluid, amniotic synovial fluid and sputum. Their key function being intercellular communication with both neighbouring well distant cells. Cancer exosomes have been shown to regulate organ-specific metastasis. However, little is known about the functional differences molecular consequences of normal cells responding...
The objective of this study was to evaluate the biocompatibility zirconium phosphate (ZrP) nanoplatelets (NPs), and their use in drug delivery. ZrP doxorubicin-intercalated (DOX:ZrP) NPs were characterized by using X-Ray Powder Diffraction (XRPD), Thermogravimetric Analysis (TGA), Transmission Electron Micrography (TEM), Scanning Microscopy (SEM) Atomic Force (AFM). Biocompatibility evaluated human embryonic kidney (HEK-293), breast cancer (MCF-7), metastatic (MDA-MB-231), ovarian (OVCAR-3),...
In the present study, we have synthesized silver nanoparticles (AgNPs) using Pueraria tuberosa aqueous extract (PTAE) in a straightforward manner without involvement of toxic chemicals. Various reaction parameters (reaction time, AgNO3 concentration, pH, temperature and PTAE concentration) were optimizeded for synthesis AgNPs through visual observation colour change absorption peak by UV-Vis spectroscopy. The green analyzed DLS, FTIR, SEM, TEM, EDS XRD their bio-physical characteristics....
Hydrogels with the main objective of releasing mesalamine (5-aminosalicylic acid) in colon a modified manner were formulated present work using free-radical polymerization approach. Different ratios hyaluronic acid cross-linked methacrylic and acrylic acids methylenebis(acrylamide). The development new polymeric network successful loading drug revealed by Fourier transform infrared spectroscopy. Thermogravimetric analysis demonstrated that hydrogel was more thermally stable than pure polymer...
Self-nanoemulsifying drug delivery systems (SNEDDS) have become a popular formulation option as nanocarriers for poorly water-soluble drugs. The objective of this study was to investigate the factor that can influence design successful lipid classification system (LFCS) Type III SNEDDS and improve oral bioavailability (BA) fenofibrate.LFCS were designed using various oils, surfactants, and/or cosolvents (in considering polarity lipids) model anticholesterol drug, fenofibrate. developed...
Genistein (GEN), a natural isoflavone possesses wide range of pharmacological properties and nutraceutical applications. GEN has been studied for its anticancer activity against different types cancers, but use in clinical practice is limited due to low water solubility, rapid metabolism excretion, lack cancer cell targeting poor bioavailability. In the present study, we investigated folate receptor-targeted PEGylated poly(lactide-co-glycolide) nanoparticles (PLGA-PEG-FA NPs) containing...
The utilization of phytoconstituents in skin care products has emerged as a notable trend due to their recognized safety and therapeutic efficacy. However, the challenge lies improving effective delivery specific tissues, primarily attributed poor solubility low permeability. This study endeavors address this by developing, optimizing characterizing Cucumis melo var. agrestis (CME) extract loaded nanoemulsion gel (CME-NEG), aiming enhance permeability antifungal activity. Herein,...
Age-related neurodegenerative diseases and vascular dementia are major challenges to the modern health care system. Most associated with impaired spatial working memory anxiety-like behavior. Thus, it is important understand underlying cellular mechanisms of in different regions brain develop an effective therapeutic approach. In our previous research paper, we have reported ameliorative effect curcumin Cd-induced hippocampal neurodegeneration. However, recently many researchers had role...
Propofol is a relatively short-acting potent anesthetic lipophilic drug used during short surgical procedures. Despite the success of propofol intravenous emulsions, drawbacks to such formulations include inherent emulsion instability, lack safe vehicle prevent sepsis, and concern regarding hyperlipidemia-related side effects. The aim current investigation was develop novel, lipid-based self-nanoemulsifying delivery system (SNEDDS) for with improved stability activity human use.A series...
Several biologically relevant phospholipids were assessed as potential carriers/additives for rapidly dissolving solid formulations of piroxicam (Biopharmaceutics Classification System Class II drug). On the basis in vitro dissolution studies, dimyristoylphosphatidylglycerol (DMPG) was ranked first potent rate enhancer model drug. Subsequently, dispersions varying piroxicam/DMPG ratios prepared and further investigated. Within concentration range studied (6.4-16.7 wt %), from appeared to...
Objective: The focus of this study was to develop and optimize in situ implant formulation meloxicam by quality design (QbD) principle for long-term management musculoskeletal inflammatory disorders.Methods: optimized Box–Behnken with polylactide-co-glycolide (PLGA) level (X1), N-methyl pyrrolidone (X2) PLGA intrinsic viscosity (X3) as the independent variables initial burst release drug (Y1), cumulative (Y2), dissolution efficiency (Y3) dependent variables. physicochemically characterized...
Nimbolide (Nim), a limonoid obtained from the neem tree, Azadirachta indica, has several pharmacological properties, including anticancer effects in different type of cancers. No drug-delivery system been reported for enhancing therapeutic application this novel hydrophobic molecule.In present research, poly(lactic-co-glycolic acid) (PLGA) nanoparticles Nim (Nim-nano) were formulated by nanoprecipitation, characterized physicochemical and screened potential breast (MCF-7 MDA-MB-231)...
Nowadays, nanotechnology is extensively employed in the medical profession. In this study, we used aqueous extract of bark Mitragyna parvifolia to synthesize silver nanoparticles (AgNPs) by microwave-assisted green synthesis. The synthesis AgNPs was confirmed visual color change brown and characteristic surface plasmon resonance peak at 432 nm. hydrodynamic diameter 171.81 nm having a zeta potential −24.14 mV; Fourier Transmission Infrared Spectroscopy presence different functional groups on...