Chihiro NAKAGAWA

ORCID: 0000-0003-2301-1514
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About
Contact & Profiles
Research Areas
  • Vehicle Dynamics and Control Systems
  • Vibration and Dynamic Analysis
  • Engineering Applied Research
  • Soil Mechanics and Vehicle Dynamics
  • Simulation and Modeling Applications
  • Autonomous Vehicle Technology and Safety
  • Structural Engineering and Vibration Analysis
  • Mechanical Engineering and Vibrations Research
  • Ergonomics and Musculoskeletal Disorders
  • Seismic Performance and Analysis
  • Robotic Locomotion and Control
  • Fluid Dynamics Simulations and Interactions
  • Control and Dynamics of Mobile Robots
  • Dynamics and Control of Mechanical Systems
  • Structural Health Monitoring Techniques
  • Evacuation and Crowd Dynamics
  • Fluid Dynamics and Vibration Analysis
  • Robotic Path Planning Algorithms
  • Railway Engineering and Dynamics
  • Stroke Rehabilitation and Recovery
  • Hydraulic and Pneumatic Systems
  • Cerebral Palsy and Movement Disorders
  • Earthquake and Tsunami Effects
  • Soft Robotics and Applications
  • Biomimetic flight and propulsion mechanisms

Osaka Metropolitan University
2022-2024

Osaka Prefecture University
2015-2024

Kindai University
2019-2024

Yokohama Sakae Kyosai Hospital
1995-2023

University of Transport and Communications
2022

Japan Science and Technology Agency
2022

Osaka City University
2011-2020

Osaka University
2005-2019

Kitasato University Hospital
2017

The University of Tokyo
2006-2009

Personal mobility vehicles (PMVs) have increasingly attracted research interest as new individual transportation that are environmentally friendly, compact, and convenient to use. It is important ensure the safety comfort of pedestrians sharing space with PMVs. In this paper, we developed a simulation model considering interaction between PMV pedestrians, investigated effects in pedestrian flows using concept personal (PS), which invasion by others induces psychological strain. To estimate...

10.1109/tits.2014.2388219 article EN IEEE Transactions on Intelligent Transportation Systems 2015-02-20

Introduction: Warfarin and direct oral anticoagulants (DOACs) have been widely used in antithrombotic therapy.Although warfarin use has suspected to be associated with osteoporosis risk, several studies shown otherwise.Conversely, a few reports found an association between DOACs osteoporosis.This study therefore clarifies the by analyzing real-world data using different methodologies, algorithms, databases.Methods: Real-world from US Food Drug Administration Adverse Event Reporting System...

10.7150/ijms.39523 article EN cc-by-nc International Journal of Medical Sciences 2020-01-01

Pancreatic cancer-related mortality is increasing worldwide, and prevention methods effective novel therapies are required. In pancreatic cancer, sodium-glucose cotransporters (SGLT) involved in glucose uptake. This study aimed to clarify the association between SGLT2 inhibitors cancer development.A nested case-control was conducted using JMDC administrative claims database (January 2005 June 2020). Patients newly diagnosed with type 2 diabetes mellitus (T2DM) were included, cases defined as...

10.5414/cp204465 article EN International Journal of Clinical Pharmacology and Therapeutics 2023-08-30

We present two cases of benign oncocytoma derived from the parotid gland and minor salivary one case malignant gland. The proliferative activity tumor cells was evaluated immunohistochemically for Ki-67. average frequency Ki-67-positive 3.3% in oncocytomas 6.5% oncocytoma. higher might reflect active cell proliferation. Ki-67 immunostaining may be useful distinguishing a

10.1159/000027766 article EN ORL 2000-01-01

Background: Osteoporosis, which is a major public health concern, has been known to reduce health-related quality of life. Some studies have suggested that antipsychotics could perhaps cause osteoporosis by increasing serum prolactin levels. However, the association between and risk for developing controversial. Objective: The present study aimed assess antipsychotic use onset in real-world settings. Methods: A multimethod data-mining approach using different algorithms databases was used....

10.1177/1060028020913974 article EN Annals of Pharmacotherapy 2020-03-18

Treatment of rheumatoid arthritis (RA) has advanced with the introduction biological disease-modifying antirheumatic drugs. However, more than 20% patients RA still have moderate or severe disease activity. Hence, novel drugs are required. Recently, drug repurposing, a process identifying new indications for existing drugs, received great attention. Furthermore, few reports shown that antipsychotics capable affecting several cytokines also modulated by Therefore, we investigated association...

10.1177/1759720x211047057 article EN cc-by-nc Therapeutic Advances in Musculoskeletal Disease 2021-01-01

Hyperuricemia is defined as high uric acid levels within the bloodstream and commonly associated with gout, type 2 diabetes mellitus, kidney disease. Sodium-glucose cotransporter inhibitors (SGLT2i) are novel drugs that prevent glucose reabsorption; additionally, this drug has shown promising results in patients at risk of developing cardiovascular or renal complications by lowering levels. This study aimed to investigate association between SGLT2i hyperuricemia. Here, a self-controlled...

10.1248/bpb.b24-00330 article EN Biological and Pharmaceutical Bulletin 2024-11-07

Personal mobility vehicles (PMVs) as new individual transportation have been proposed around the world. It is important to ensure safe operation of a PMV, especially when PMV travels in pedestrian flows. In this work, affinity felt by pedestrians toward compact use which can be considered an extension walking, investigated simulations. The simulation model built introducing idea personal space. space invasion others induces psychological strain. To evaluate between and surrounding...

10.1109/syscon.2012.6189432 article EN 2022 IEEE International Systems Conference (SysCon) 2012-03-01

From the viewpoints of environmental protection, support for aged and ensuring right to mobility, there is a need develop new type mobility vehicle that provides more effective transportation. The authors propose an inverted pendulum with pedals as one forms personal vehicles (PMVs). In this paper, steering performance discussed based on experiments prototype. experimental results, it was confirmed errors from five subjects target trajectory five-grade evaluation maneuverability were...

10.1063/2.1301309 article EN cc-by-nc-nd Theoretical and Applied Mechanics Letters 2013-01-01

In order to tackle with the problems surrounding environment, aged society and individual mobility right, new type of vehicle which is compact convenient expected be developed. The authors have been investigated such a called Personal Mobility Vehicle (PMV), friendly for human environment. this paper, we proposed two-wheeled inverted pendulum moved by pedaling. basic mechanism consists system stabilization control pedaling torque human. This has following benefits. By adding power, battery...

10.1299/jsdd.5.389 article EN Journal of System Design and Dynamics 2011-01-01

Abstract Cardiac glycosides, such as digoxin, inhibit Na + /K -ATPases and cause secondary activation of /Ca 2+ exchangers. Preclinical investigations have suggested that digoxin may anticancer properties. In order to clarify the functional mechanisms in cancer, we performed an integrative analysis clinical bioinformatics databases. The US Food Drug Administration Adverse Event Reporting System Japan Medical Data Center claims database were used databases evaluate reporting odds ratios...

10.1038/s41598-019-53392-y article EN cc-by Scientific Reports 2019-11-12

For the reduction of environmental load, support aged society and right to mobility, new individual mobility methods are expected. As a method, Personal Mobility Vehicles (PMVs) investigated developed these days. Compact PMVs have enough possibility be used in pedestrian areas for its convenience. It is important insure safety comfort pedestrians when they share spaces with PMV users. In this paper, order evaluate influence on pedestrians, we measured personal space who walked against user....

10.1299/kikaic.78.3332 article EN TRANSACTIONS OF THE JAPAN SOCIETY OF MECHANICAL ENGINEERS Series C 2012-01-01

These days, the dynamically stabilized two-wheeled vehicles are investigated as a form of new personal mobility vehicle. With control theory inverted pendulum, they kept in equilibrium. It is important to investigate stability vehicle especially on rough road. For this background, authors responses which by an optimal controller, vertical vibrations. theoretical analysis, numerical simulations and experiments using large scale vibration exciter, examined. The results show system dynamics...

10.1299/jmtl.2.78 article EN Journal of Mechanical Systems for Transportation and Logistics 2009-01-01

Personal mobility vehicles (PMVs) as new individual transportation have been proposed around the world. It is important to ensure safe operation of a PMV, especially when PMV shares space with pedestrian. In this paper, in order evaluate influence size on pedestrians, we measured personal pedestrians who walked against user. From experimental results, it was shown that width and height step significantly affected pedestrians. Especially becomes larger, front expanded. simulation introducing...

10.1115/dscc2012-movic2012-8578 article EN 2012-10-17

The use of shape memory alloy (SMA) wire actuators for a moving body has some advantages over other conventional because the high specific power, small size, and simplicity these actuators. However, large power consumption SMA prevents its practical use. This paper shows how to optimize input voltage First, numerical actuator model is created from measured data. Next, waves are optimized three evaluation functions using multiobjective optimization: maximum voltage, time-averaged consumption,...

10.1109/tmech.2018.2836352 article EN IEEE/ASME Transactions on Mechatronics 2018-05-15

<div class=""abs_img""><img src=""[disp_template_path]/JRM/abst-image/00260003/08.jpg"" width=""300"" />Analytical model</span></div> A flexible fish-like biomimetic robot developed for use in narrow passage flows was downsized using shape memory alloy (SMA) actuators. We constructed a fluid-body-coupled model of the and considered undulatory swimming effect nonlinear SMA characteristics. An experimental also to confirm analytical model’s feasibility. Shrinkage due...

10.20965/jrm.2014.p0349 article EN cc-by-nd Journal of Robotics and Mechatronics 2014-06-20

An inverted pendulum vehicle controlled by movement of driver's center gravity, such as Winglet or Segway is one Personal Mobility Vehicles (PMV). PMV sometimes expected to be used in pedestrian space. However the dynamics an and a driver haven't been studied enough. In this study, coupling model human built using Multibody Dynamics. The expressed 2 rigid bodies (tire body) 8 bodies(foot, lower leg, femoral, body, head, upper arm, hand). Two types impulses external forces are inputted...

10.1299/kikaic.78.1497 article EN TRANSACTIONS OF THE JAPAN SOCIETY OF MECHANICAL ENGINEERS Series C 2012-01-01

A vehicle for the individual usage called a personal mobility (PMV) is investigated in terms of its affinity with pedestrians. PMV sometimes share space Therefore, it very important to ensure safety and comfort pedestrians PMVs space. In this investigation, we evaluate between using The which causes psychological strain by approach others. By space, strains are measured physical distances. It shown that two-wheeled dynamically stabilized has higher than bicycle, 2,0 2.3 times larger spaces...

10.1299/kikaic.76.2493 article EN TRANSACTIONS OF THE JAPAN SOCIETY OF MECHANICAL ENGINEERS Series C 2010-01-01

Abstract The association between statins and open-angle glaucoma (OAG) remains controversial. This study investigated the relationship OAG in Japanese patients with dyslipidemia using administrative claims database. A nested case–control two models was conducted JMDC database (01/2005–01/2020). onset of OAG: index date defined as diagnosis glaucoma, prescription anti-glaucoma drugs, or surgery glaucoma. For each case, a maximum 10 age-, sex-, calendar year/month–matched controls were...

10.1038/s41598-023-38957-2 article EN cc-by Scientific Reports 2023-07-19
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