A5055438797- Pediatric health and respiratory diseases
- Cleft Lip and Palate Research
- Oral microbiology and periodontitis research
- Cytokine Signaling Pathways and Interactions
- Medical and Biological Sciences
- Craniofacial Disorders and Treatments
- Probiotics and Fermented Foods
- Antimicrobial Resistance in Staphylococcus
- T-cell and Retrovirus Studies
- Salivary Gland Disorders and Functions
- Oral Health Pathology and Treatment
- Inflammasome and immune disorders
- Tracheal and airway disorders
- Therapeutic Uses of Natural Elements
- Hair Growth and Disorders
- Psoriasis: Treatment and Pathogenesis
- HIV/AIDS oral health manifestations
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Antimicrobial Peptides and Activities
- Bee Products Chemical Analysis
- Vitamin C and Antioxidants Research
- Papaya Research and Applications
- Dermatology and Skin Diseases
- Mycobacterium research and diagnosis
- Neurological Disorders and Treatments
Kabardino-Balkarian State University
2011-2024
Kabardino-Balkarian Scientific Center
2017
Pirogov Russian National Research Medical University
1998-2004
Food supplements based on fermented Carica papaya and Morinda citrifolia, known for their immune modulating, redox balancing, anti-inflammatory effects, were added to conventional treatment protocols prescribed patients recovering after severe moderate COVID-19 disease in order alleviate long-lasting post-COVID symptoms. A randomized single-center placebo-controlled clinical laboratory study was designed performed (total number of participants 188, with delta variant virus 157, omicron 31)....
To distinguish clinical effects and mechanisms of sodium monofluorophosphate plus xylitol herbal extracts Swiss medicinal plants (Chamomilla recutita, Arnica montana, Echinacea purpurea, Salvia officinalis).A 2-month-long comparative study toothpaste containing 1450 ppm (control, 15 patients) additionally the herbs (experiment, 35 was performed on patients with gingivitis initial stage periodontitis. Clinical indices gingivitis/periodontitis were quantified by Loe & Silness's, CPITN, OHI-S,...
Введение. Исследование биомаркеров N-ацетил-бета-Д-глюкозаминидазы, тканевого ингибитора матриксных протеиназ-1 и proMMP1 у пациентов с артериальной гипертензией ишемической болезнью сердца, в том числе кардиосклерозом, может дать здравоохранению новый инструмент для определения степени тяжести данных форм патологии, а также их ранней диагностики. Цель. кардиосклерозом. Материалы методы. Исследовано 90 (40 мужчин 50 женщин среднего возраста 53±10 лет), разделенных на 3 группы (АГ, ИБС,...
Пациентка 60 лет находилась в госпитале особо опасных инфекций № 1 Нальчика 47 койко-дней с диагнозом «COVID-19, тяжелое течение, U07.1. Осложнения: внегоспитальная двусторонняя полисегментарная пневмония, ПП 75%. Несахарный диабет центрального генеза, средней степени тяжести, стадия субкомпенсации». На фоне основного заболевания у пациентки появились жалобы на неутолимую жажду и усиленное мочеиспускание. Уровень антидиуретического гормона (АДГ) оказался ниже нормы (0,81 нг/л). Пациентке был...
Введение. К клиническим проявлениям нарушений местного иммунитета у детей с врожденными расщелинами неба относятся хронические инфекционно-воспалительные заболевания лор-органов. После оперативного устранения дефекта очаги воспаления исчезают не сразу и нарушение микробиоценоза ороназофарингеальной области приходит к норме мгновенно, они претерпевают изменения течением времени. В связи этим актуальным является изучение характера лор-патологии состояния микрофлоры прооперированных разных...
Введение. Совершенствование диагностических и прогностических критериев, направленных на выявление факторов риска развития периимплантита, является актуальной проблемой современной стоматологии. Анализ цитокинового статуса может служить основанием для прогнозирования периимплантитов, представляя собой инструмент индивидуальной оценки рисков исхода дентальной имплантации. Цель. Изучение локальных показателей свободнорадикального периимплантных тканей осложнений Материалы методы. Обследованы...
Plant-derived secondary metabolites (polyphenols/terpenes/alkaloids) and microbial exometabolites/membrane components of fermented tropical fruits are known as highly bioavailable biomolecules causing skin hair improvement effects (wound healing, anti-inflammatory, antioxidant, antidiabetic, antiacne, skin/hair microbiota balancing, growth-promoting, loss-inhibiting). Caffein is considered a growth promoter. A randomized placebo- caffein-controlled clinical trial on the efficacy papaya (FP)...
The clinical efficacy of topical administration standardised fermented papaya gel (SFPG), known to have antioxidant and anti-inflammatory properties, versus conventional therapy was evaluated in a group 84 patients with moderate-to-severe periodontitis, randomly assigned control (<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="M1"><mml:mi>n</mml:mi><mml:mo>=</mml:mo><mml:mn fontstyle="italic">45</mml:mn></mml:math>) undergoing traditional pharmacologic/surgical protocols or...
Causative connections between infections and cancer are ascertained for several types of viruses, bacteria, parasites. The mechanisms induction in chronically infected inflamed tissues strongly implicate oxygen- nitrogen-centered reactive species, an impairment redox-sensitive molecular pathways involved the tumorigenic transformation, tumor growth, altered immune defense, cell death survival. Here, we briefly reviewed mechanistic data on carcinogenesis progression three major...
Bacteria colonizing human intestine adhere to the gut mucosa and avoid innate immune system. We previously demonstrated that Escherichia coli isolates can adsorb mucin from a diluted solution in vitro. Here, we evaluated effect of adsorption by E. cells on neutrophil activation Activation was based detection reactive oxygen species production chemiluminescent reaction (ChL), observation morphological alterations neutrophils exocytosis myeloperoxidase lactoferrin. report adsorbed SharL1...
In the observational clinical study, we identified oxidative markers of HPV-associated cervical carcinogenesis and local/circulating ligands TNF-alpha-induced apoptosis. Cervical biopsies 196 females infected with low-cancer-risk HPV10/13 or high-cancer-risk HPV16/18 (healthy, pre-cancerous CIN I II, III carcinoma) were analysed for OH radical scavenging, catalase, GSH-peroxidase, myeloperoxidase (MPO), nitrate/nitrite, nitrotyrosine, isoprostane. Ligands TNF-alpha-dependent apoptosis...
Water depleted of heavy isotopes, such as 2H1 and 18O16 (HIDW), has shown numerous biological/health effects in vitro, vivo, epidemiological studies. Major observations were related to cell growth/differentiation, immune/nervous system responses, endurance/adaptation, mitochondrial electron transfer, energy production, glucose metabolism, etc. No human studies confirm physiological, metabolic, immune responses the consumption HIDW have been performed. A placebo-controlled study on healthy...
РОЛЬ пРОВОСпАЛИТЕЛЬНЫХ ЦИТОКИНОВ В РАЗВИТИИ ХРОНИЧЕСКОГО пАРОДОНТИТА А
The aim of the study was to identify indicators cytokine and free radical periodontal status patients with moderate severity periodontitis that occurred after a new coronavirus infection 1–3 monthes ago. IL‑1ß, IL‑6, IL‑10, IL‑17A, nitrate-nitrite concentration, antioxidant activity, matrix metalloproteinase MMP‑8 in gingival fluid samples were studied. A significant increase local level methylproteinase‑8 nitrate-nitrites found compared diseases same severity, who have not had covid (p <...
Relevance. The presence of an orthodontic appliance within the oral cavity enhances formation supplementary retention sites for adhesion microorganisms. porosity acrylic base materials, coupled with their limited polishability, further predisposes surface to contamination by a biofilm Evaluating capacity materials attract bacterial adherence surfaces represents crucial phase in patient treatment. Purpose. This study aims perform comprehensive clinical and laboratory investigation into...
Введение. Одними из наиболее частых жалоб пациентов, перенесших COVID-19, являются различные гнойно-воспалительные заболевания органов ороназофарингеальной области рецидивирующего характера, в связи с чем актуальным является исследование причин несостоятельности защитного потенциала верхних дыхательных путей, слизистых этой области. Цель работы. Целью исследования было изучение иммунологических и микробиологических особенностей у пациентов постковидным синдромом, тяжелую форму COVID-19...
The local mechanisms of protection the mucous membranes oronasopharynx have their own characteristics, which should be considered when planning surgical interventions and selecting therapies. success is largely determined by understanding risks comprehensive prevention development. Tissue injury causes release cytokines, prostaglandins, resulting in increased interaction between leukocytes, platelets, endothelial cells, extracellular matrix. different types cells ensures stability body...