A5085225556- Pluripotent Stem Cells Research
- Immune Cell Function and Interaction
- CAR-T cell therapy research
- RNA Interference and Gene Delivery
- CRISPR and Genetic Engineering
- 3D Printing in Biomedical Research
- Reproductive System and Pregnancy
- Herpesvirus Infections and Treatments
- Prostate Cancer Treatment and Research
- Microbial infections and disease research
- Cancer-related molecular mechanisms research
- Neurological and metabolic disorders
- Therapeutic Uses of Natural Elements
- Cervical Cancer and HPV Research
- Microencapsulation and Drying Processes
- Seaweed-derived Bioactive Compounds
- Epigenetics and DNA Methylation
- Neurological disorders and treatments
- Neurogenesis and neuroplasticity mechanisms
- Parkinson's Disease Mechanisms and Treatments
- Renal and related cancers
Federal Medical-Biological Agency
2019-2024
Lomonosov Moscow State University
2019-2023
Moscow State University
2023
Federal Research and Clinical Center of Physical-Chemical Medicine named after Y.M. Lopukhin
2023
Abstract Background Dozens of transplants generated from pluripotent stem cells are currently in clinical trials. The creation patient-specific iPSCs makes personalized therapy possible due to their main advantage immunotolerance. However, some reports have claimed recently that aberrant gene expression followed by proteome alterations and neoantigen formation can result recognition autologous T-cells. Meanwhile, the possibility NK-cell activation has not been previously considered. This...
The mismatch of HLA haplotypes between donor and recipient adversely affects the outcome tissue transplantation. TheB2Mgene knockout (B2M-KO) disrupts I heterodimer formation; therefore,B2M-KO cells have reduced immunogenicity to allogeneic CD8+ T cells. Thus, theB2M-KO IPSCs their derivatives can potentially solve a problem immunological compatibility in transplantations. Using CRISPR/Cas9-mediated genome editing, we generated human B2M-KO iPSC line (RCPCMi007-A-1). RCPCMi007-A-1 iPSCs...
A bstract Background Prostate adenocarcinoma (PRAD) is the second leading cause of cancer-related deaths in men. High variability DNA methylation and a high rate large genomic rearrangements are often observed PRAD. Results To investigate reasons for such variance, we integrated methylation, RNA-seq, copy number alterations datasets from The Cancer Genome Atlas (TCGA), focusing on PRAD, employed weighted gene co-expression network analysis (WGCNA). Our results show that only single cluster...
Induced pluripotent stem cells (iPSCs) due to their ability differentiate into the desired cell type are a promising tool for solving problems of transplantation medicine. In addition, reprogramming technology makes it possible obtain personalized, i.e., patient-specific, product whose should not cause related histocompatibility transplanted tissues and organs. At same time, inconsistent information about main advantage autologous iPSC derivatives – lack immunogenecity still casts doubt on...
Abstract Background : Dozens of transplants generated from pluripotent stem cells are currently in clinical trials. The creation patient-specific iPSCs makes personalized therapy possible due to their main advantage immunotolerance. However, some reports have claimed recently that aberrant gene expression followed by proteome alterations and neoantigen formation can result recognition autologous T-cells. Meanwhile, the possibility NK-cell activation has not been previously considered. This...
Parkinson’s disease arises from the demise of dopaminergic neurons in substantia nigra resulting both environmental and hereditary factors. Drug interventions can solely delay progression, but cannot provide a cure. Therefore, cell replacement therapy may represent promising treatment approach. Although United States has already employed this technology, independent clinical preclinical trials are mandatory for its inclusion Russia. The iPSC technology enables acquisition personalized lines...