A5033864292- Parkinson's Disease Mechanisms and Treatments
- Neurological disorders and treatments
- Alzheimer's disease research and treatments
- Neuroscience and Neuropharmacology Research
- Genetic Neurodegenerative Diseases
- Pluripotent Stem Cells Research
- Ginkgo biloba and Cashew Applications
- Neuroinflammation and Neurodegeneration Mechanisms
- Biochemical effects in animals
- Biochemical Analysis and Sensing Techniques
- Neurological and metabolic disorders
- Tryptophan and brain disorders
- Neurological Disorders and Treatments
- Nerve injury and regeneration
- Amyotrophic Lateral Sclerosis Research
- Natural Antidiabetic Agents Studies
- RNA Interference and Gene Delivery
- Regulation of Appetite and Obesity
- Free Radicals and Antioxidants
- Olfactory and Sensory Function Studies
- Pharmacology and Obesity Treatment
- Stress Responses and Cortisol
- Neurological Disease Mechanisms and Treatments
- Neurogenesis and neuroplasticity mechanisms
- CRISPR and Genetic Engineering
Research Center of Neurology
2017-2024
Russian Academy of Sciences
2017-2023
Laboratory of Molecular Genetics
2017
Kurchatov Institute
2017
Institute of Molecular Genetics
2017
Introduction. Experimental and clinical studies have repeatedly shown the interplay between intestinal microbiota properties nervous system, with a clear link established changes in development of neurodegenerative process. It is thought that inflammation disturbances provoke spread pathological forms a-synuclein which recognized as main cause neurodegeneration Parkinson disease (PD). Aim study: to identify effect pharmabiotic based on Lactobacillus fermentum U-21 strain Wistar rats...
BACKGROUND: In recent years the theme of relationship Alzheimers disease (AD) and metabolic disorders has been widely discussed. Nevertheless, it remains unclear whether AD is a direct cause carbohydrate metabolism or presence classical risk factors for type 2 diabetes mellitus (DM 2), primarily obesity, that significantly increases AD. AIM: To evaluate separate contribution two to development metabolism: (1) weight gain due high-calorie diet (2) experimental-induced METHODS: Male Wistar...
Parkinson’s disease (PD) is a common neurodegenerative disorder with variety of motor and non-motor features. Non-motor symptoms, such as gastrointestinal dysfunction, usually set in 5 to 15 years earlier than manifestations. Cytoplasmic aggregates phosphorylated α-synuclein are typical marker PD. They observed not only cerebral neurons but also intramural plexuses the intestine. Therefore, it essential investigate peripheral component molecular pathogenesis using PD models, including those...
The aim of the study was to evaluate effect genome editing on outcome experimental transplantation neuronal precursors obtained from a patient with hereditary form Parkinson's disease.Materials and Methods.Parkinsonian syndrome modeled in Wistar rats (n=24) by unilateral administration (into substantia nigra) neurotoxin 6-hydroxydopamine, that selectively destroy dopaminergic neurons.The neural progenitors were differentiated induced pluripotent stem cells (iPSCs) derived PARK8 disease...
ВеСтНИК РоССИйСКой ВоеННо-МеДИцИНСКой АКАДеМИИ Всероссийская научно-практическая конференция 2018, ПРИЛоЖеНИе 3 (63) «Дегенеративные и сосудистые заболевания нервной системы» 104 НАУчНЫЕ СТАТьИ ВЫЯВЛЕНИЕ НЕМОТОРНЫх НАРУШЕНИЙ НА кЛАССИчЕСкОЙ МОДЕЛИ БОЛЕЗНИ ПАРкИНСОНА Ставровская А.В., Ольшанский А.С., Ямщикова Н
Оценка эффективности антиоксидантных (АО) препаратов при введении на поздней стадии экспериментального паркинсонизма в условиях тотальной гибели нейронов черной субстанции (ЧС) и нарушений дофаминергической иннервации стриатума является актуальной проблемой. Целью исследования было оценить эффективность АО карнозина липоевой кислоты (ЛК) модели паркинсонизма. Паркинсонизм индуцировали у крыс с помощью унилатерального стереотаксического введения 6-гидроксидофамина (ГДА) ЧС правого полушария....
Introduction. Over the past several decades, study of mutations associated with motor neuron disease has led to development a number transgenic animal models disease. One causes familial form this disorder is in gene encoding Cu/Zn superoxide dismutase 1. The B6SJL-Tg (SOD1*G93A) mouse strain expresses mutant human Aim study. To assess functions, dynamics survival, and morphological changes spinal cord mice. Material methods. In total, 31 animals have been studied. Starting from age 22...
Parkinson’s disease arises from the demise of dopaminergic neurons in substantia nigra resulting both environmental and hereditary factors. Drug interventions can solely delay progression, but cannot provide a cure. Therefore, cell replacement therapy may represent promising treatment approach. Although United States has already employed this technology, independent clinical preclinical trials are mandatory for its inclusion Russia. The iPSC technology enables acquisition personalized lines...
Introduction. The model involving injection of quinolinic acid (QA) into the rat striatum simulates many clinical and morphological characteristics Huntingtons disease (HD). Searching for effective treatment methods is rather topical because fatality HD. One such to create a neuroprotective environment slow down current degenerative process and/or replace dead neurons. In particular, this can be performed by transplantation cells capable undergoing neuronal differentiation integration proper...
Introduction. The model involving injection of quinolinic acid (QA) into the rat striatum simulates many clinical and morphological characteristics Huntingtons disease (HD). Searching for effective treatment methods is rather topical because fatality HD. One such to create a neuroprotective environment slow down current degenerative process and/or replace dead neurons. In particular, this can be performed by transplantation cells capable undergoing neuronal differentiation integration proper...
Background: Obesity is a risk factor for cognitive disorders. However, it still unknown whether low-calorie diet will improve function in obese patients. Aim: To evaluate and metabolic features male Sprague-Dawley rats receiving high-fat diets. Materials methods: The work was carried out on Sprague Dawley (n = 32), which were divided into 2 groups with 16 animals each group: Control (normal / diet) (high-fat diet). In 90 days the of group transferred to diet, continued receive diet. assess...
The late stage of Parkinson’s disease is characterized by massive neuronal loss in the substantia nigra (SN) and degeneration dopaminergic innervation striatum. There a need to assess neuroprotective effect antioxidants (AO) at this disease. aim our study was efficacy two AO, carnosine lipoic acid (LA), rat model late-stage parkinsonism. pathology induced unilateral injection 6-hydroxydopamine (6-OHDA) into SN right brain hemisphere. AO were administered 4 times, starting on day 14 following...