A5007564721- Allergic Rhinitis and Sensitization
- Food Allergy and Anaphylaxis Research
- Dermatology and Skin Diseases
- Contact Dermatitis and Allergies
- Asthma and respiratory diseases
- Pediatric health and respiratory diseases
- Nail Diseases and Treatments
- Immune responses and vaccinations
- Urinary Tract Infections Management
- Vaccine Coverage and Hesitancy
- Pelvic floor disorders treatments
- Fungal Biology and Applications
- Respiratory viral infections research
- Respiratory and Cough-Related Research
- Essential Oils and Antimicrobial Activity
- Ocular Surface and Contact Lens
- Immunotherapy and Immune Responses
- Lichen and fungal ecology
- Infant Health and Development
- Gut microbiota and health
- Food Quality and Safety Studies
- Immunodeficiency and Autoimmune Disorders
- Urinary Bladder and Prostate Research
- Plant Pathogens and Fungal Diseases
- Olfactory and Sensory Function Studies
Inmunotek (Spain)
2015-2024
Respiratory Research Institute
2024
Técnicas y Servicios de Ingeniería (Spain)
2010
LETI Pharma (Germany)
1994-2008
Universitat de Barcelona
1950-1953
Final kernel number in maize (Zea mays L.) is closely associated with the physiological condition of crop during critical period bracketing silking. The objective this study was to determine whether there a common underlying relationship between per plant (KNP) and growth rate (PGR) that when varies because different abiotic stresses. A KNP PGR obtained from previous variation density incident radiation used as reference. were measured experiments which plant, nitrogen (N), water...
Allergen immunotherapy (AIT) is the only curative treatment for allergy. AIT faces pitfalls related to efficacy, security, duration, and patient compliance. Novel vaccines overcoming such inconveniences are in demand.We sought study immunologic mechanisms of action novel targeting dendritic cells (DCs) generated by coupling glutaraldehyde-polymerized grass pollen allergoids nonoxidized mannan (PM) compared with (P) or native extracts (N).Skin prick tests basophil activation N, P, PM were...
MV130 is an inactivated polybacterial mucosal vaccine that confers protection to patients against recurrent respiratory infections, including those of viral etiology. However, its mechanism action remains poorly understood. Here, we find intranasal prophylaxis with modulates the lung immune landscape and provides long-term heterologous infections in mice. Intranasal administration systemic candidiasis wild-type Rag1-deficient mice lacking functional lymphocytes, indicative innate...
Recurrent wheezing in children represents a severe public health concern. Wheezing attacks (WA), mainly associated with viral infections, lack effective preventive therapies.
BackgroundRecurrent urinary tract infections (UTIs), which consist of three or more episodes in 1 year two 6 months, affect 5% to 10% women. MV140, a sublingual preparation whole-cell inactivated bacteria, has shown clinical benefit observational studies. This trial examined treatment with MV140 prevent recurrent UTI.MethodsIn this multicenter, randomized, double-blind, placebo-controlled, parallel-group 1-year trial, 240 women 18 75 years age from Spain and the United Kingdom UTI were...
Recurrent urinary tract infections (RUTIs) are one of the most common bacterial infectious diseases, especially in women. Antibiotics remain mainstay treatment, but their overuse is associated with antibiotic-resistant and deleterious effects microbiota. Therefore, alternative approaches fully demanded. Sublingual immunization MV140 (Uromune), a polyvalent preparation (PBP) whole heat-inactivated bacteria, demonstrated clinical efficacy for treatment RUTIs, involved immunological mechanisms...
Respiratory tract infections (RTIs) are among the most common and important problems in clinical medicine, making antibiotics gold standard therapeutic option regardless of their frequent viral etiology. Their excessive inappropriate use contributes to rapid rise antibiotic resistance underscores need for alternative strategies, especially when dealing with recurrent RTIs. Prevention is ideal alternative, but specific vaccines targeting a wide range respiratory pathogens scarce. MV130...
Background: Little information is available on the clinical efficacy of sublingual immunotherapy (SLIT) using extracts derived from mammalian epithelia. Objectives: To assess cat SLIT based natural exposure challenge test (NCT). Material and methods: Fifty allergic patients with rhinoconjunctivitis or without asthma were included in a randomized double blind placebo controlled trial during 1 year. Twenty‐five received active treatment 25 placebo. Sublingual was assessed by to cat‐room skin...
Polymerized allergoids conjugated with mannan represent a novel approach of allergen immunotherapy targeting dendritic cells. In this study, we aimed to determine the optimal dose mannan-allergoid conjugates derived from grass pollen (Phleum pratense and Dactylis glomerata) administered via either subcutaneous or sublingual route. A randomized, double-blind, placebo-controlled trial double-dummy design was conducted, involving 162 participants across 12 centers in Spain. Subjects were...
Abstract Background Polymerized allergoids coupled to nonoxidized mannan ( PM ‐allergoids) may represent novel vaccines targeting dendritic cells DC s). ‐allergoids are better captured by s than native allergens and favor Th1/Treg cell responses upon subcutaneous injection. Herein we have studied in mice the vivo immunogenicity of administered sublingually comparison with allergens. Methods Three immunization protocols (4‐8 weeks long) were used Balb/c mice. Serum antibody levels tested...
Abstract Background Polymerized allergens conjugated to non‐oxidized mannan (PM‐allergoids) are novel vaccines targeting dendritic cells (DCs). Previous experimental data indicate that PM‐allergoids readily taken up by DCs and induce Treg cells. This first‐in‐human study was aimed evaluate safety find the optimal dose of house dust mite PM‐allergoid (PM‐HDM) administered subcutaneously (SC) or sublingually (SL). Methods In a randomized, double‐blind, double‐dummy, placebo‐controlled trial,...
Abstract Background There is still great need to develop new strategies improve the efficacy of allergen immunotherapies with optimal safety standards for patients. A promising approach couple allergoids mannan. The objective this phase IIa/IIb study was identify dose mannan‐conjugated birch pollen short‐course treatment pollen–induced allergic rhinoconjunctivitis. Methods For prospective, randomized, double‐blind, placebo‐controlled, dose‐finding study, 246 pollen–allergic adults received...
Abstract Food security is the way to quantify degree of access population has nutritious and safe food at all times. It depends on several factors, including availability affordability that food. This term should not be confused with safety, which understood discipline, process or action prevents from containing living organisms (bacteria, viruses parasites) chemical substances could cause harm health consumers. Climate change climate altering due anthropogenic activities, are adversely...
Immunotherapy for treating IgE-mediated allergies requires high doses of the corresponding allergen. This may result in undesired side effects and, to avoid them, hypoallergenic allergens (allergoids) polymerized with glutaraldehyde are commonly used. Targeting allergoids dendritic cells enhance cell uptake a more effective immunotherapy. Allergoids coupled yeast mannan, as source polymannoses, would be suitable this purpose, since mannose-binding receptors expressed on these cells....
Four administration schedules of immunotherapy have been reported: conventional, cluster, rush and ultra-rush.To evaluate the safety clinical advantage using standardized modified allergen extracts in an ultra-rush protocol without premedication and/or hospitalization.One thousand sixty-eight patients with rhinoconjunctivitis asthma sensitized to mites pollen were included a prospective observational study. Patients received therapeutic vaccine containing depigmented glutaraldehyde-modified...
<i>Background:</i> The physiochemical modification of allergens to reduce allergenicity, while retaining immunogenicity, provides a chance for the administration higher doses immunotherapy, with decreased risk systemic reactions. <i>Objective:</i> To evaluate safety depigmented glutaraldehyde-polymerized vaccine <i>Dermatophagoides pteronyssinus</i> increasing those used in normal clinical conditions comparison regular non-modified vaccine....
The major complication of allergen immunotherapy is a severe reaction.To evaluate the safety depigmented and glutaraldehyde-modified extracts in large group patients undergoing treatment.Seven hundred sixty-six patients, having rhinoconjunctivitis and/or asthma, were entered prospective, multi-centre, observational cohort study, to with modified vaccines. Patients sensitized mites pollen received therapeutic vaccine containing polymerized pollens adsorbed onto aluminium hydroxide. schedule...
Subcutaneous immunotherapy has emerged as an effective option for treating allergic diseases. Here, we assessed the clinical impact of mannan-conjugated birch pollen polymerized allergoid T502 in pollen-induced rhinoconjunctivitis.
We have recently reported that grass pollen allergoids conjugated with nonoxidized mannan of Saccharomyces cerevisae using glutaraldehyde results in a novel hypoallergenic mannan-allergen complex improved properties for allergen vaccination. Using this approach, human dendritic cells show better uptake and cytokine profile production (higher IL-10/IL-4 ratio) therapeutic purposes. Here we aim to address whether similar approach can be extended dogs canine cells. Six healthy Spanish Greyhound...