A5003186980- SARS-CoV-2 detection and testing
- Advanced biosensing and bioanalysis techniques
- HIV Research and Treatment
- SARS-CoV-2 and COVID-19 Research
- interferon and immune responses
- Biosensors and Analytical Detection
- Influenza Virus Research Studies
- Animal Virus Infections Studies
- Immune Cell Function and Interaction
- COVID-19 epidemiological studies
- COVID-19 Clinical Research Studies
- Respiratory viral infections research
- Viral Infections and Outbreaks Research
Emory University
2025
University of Wisconsin–Madison
2020-2022
Abstract Background Healthcare personnel (HCP) are at increased risk of infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). We posit that current control guidelines generally protect HCP from SARS-CoV-2 in a healthcare setting. Methods In this retrospective case series, we used viral genomics to investigate the likely source major academic medical institution Upper Midwest United States between 25 March and 27 December 2020. obtained limited epidemiological data...
The SARS-CoV-2 B.1.621 (Mu) variant emerged in January 2021 and was categorized as a of interest by the World Health Organization August 2021. This designation prompted us to study sensitivity this antibody neutralization. In live virus neutralization assay with serum samples from individuals vaccinated Pfizer/BioNTech or Moderna mRNA vaccines, we measured titers against B.1.621, an early isolate (spike 614D), concern (B.1.351, Beta variant). We observed reduced neutralizing (3.4- 7-fold...
In the past two decades, pandemic respiratory viruses (H1N1 and SARS-CoV-2) have emerged via spillover from animal reservoirs. an effort to avert future pandemics, surveillance studies aimed at identifying zoonotic high risk of spilling over into humans act monitor `viral chatter' animal-human interface. These are hampered, however, by diversity limited tools available assess risk. Methods currently in use include characterization candidate using vitro laboratory assays experimental...
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) control in the United States remains hampered, part, by testing limitations. We evaluated a simple, outdoor, mobile, colorimetric reverse-transcription loop-mediated isothermal amplification (RT-LAMP) assay workflow where self-collected saliva is tested for SARS-CoV-2 RNA. From July 16, 2020, to November 19, surveillance samples (n = 4704) were collected from volunteers and at 5 sites. Twenty-one positive RT-LAMP; 12 confirmed...
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) control in the United States remains hampered, part, by testing limitations. We evaluated a simple, outdoor, mobile, colorimetric reverse transcription loop-mediated isothermal amplification (RT-LAMP) assay workflow where self-collected saliva is tested for SARS-CoV-2 RNA. From July 16 to November 19, 2020, 4,704 surveillance samples were collected from volunteers and at 5 sites. A total of 21 positive RT-LAMP; 12 confirmed...
From 2010 to 2015, 73 common marmosets (Callithrix jacchus) housed at the Wisconsin National Primate Research Center (WNPRC) were diagnosed postmortem with lymphocytic enterocolitis. We used unbiased deep-sequencing screen blood of deceased enterocolitis-positive for viruses. In five out eight enterocolitis, we discovered a novel pegivirus not present in ten matched, clinically normal controls. The virus, which named Southwest bike trail virus (SOBV), is most closely related (68% nucleotide...
Abstract From 2010 to 2015, 73 common marmosets ( Callithrix jacchus ) housed at the Wisconsin National Primate Research Center (WNPRC) were diagnosed postmortem with lymphocytic enterocolitis. We used unbiased deep-sequencing screen blood of deceased enterocolitis-positive for presence RNA viruses. In five out eight enterocolitis, we discovered a novel pegivirus that was not present in ten subsequently deep-sequenced matched, clinically-normal no evidence The virus, which have named...