A5114860709- Ginseng Biological Effects and Applications
- Food Quality and Safety Studies
- Pharmacological Effects of Natural Compounds
- Health and Wellbeing Research
- Medicinal Plants and Neuroprotection
- Immune Cell Function and Interaction
- Neuroinflammation and Neurodegeneration Mechanisms
- Neurogenesis and neuroplasticity mechanisms
- Probiotics and Fermented Foods
- T-cell and B-cell Immunology
- Helicobacter pylori-related gastroenterology studies
- Diverse Approaches in Healthcare and Education Studies
- Gut microbiota and health
- Inflammatory Bowel Disease
- Microbial Metabolism and Applications
- Phytochemistry and Biological Activities
- Hair Growth and Disorders
- TGF-β signaling in diseases
- Cancer-related molecular mechanisms research
- Phytoestrogen effects and research
- Biological and pharmacological studies of plants
- Gastrointestinal motility and disorders
- Wound Healing and Treatments
- Cancer-related gene regulation
- Nutrition, Health and Food Behavior
Bucheon University
2021-2022
Korea Institute of Oriental Medicine
2017
Chungnam National University
2009-2014
Yonsei University
2014
Kangwon National University
2009-2013
Korea Research Institute of Bioscience and Biotechnology
2013
Huzhou University
2012
Seoul National University Hospital
2010
Seoul National University
2003-2009
Sungkyunkwan University
2008
The present study demonstrates that RA has activity of an IgA switch factor and is more specific than TGF-β1. independently caused only switching, whereas TGF-β1 IgG2b switching. We found increased production this was a result its ability to increase the frequency IgA-secreting B cell clones. Increased accompanied by GLTα. abrogated antagonist RAR. Additionally, affected intestinal in mice. Surprisingly, RA, combination with TGF-β1, notably enhanced not GLTα expression but also CCR9 α4β7 on...
Hu protein R (HuR) binds to the AU-rich element (ARE) in 3'UTR stabilize TNF-α mRNA. Here, we identified chemical inhibitors of interaction between HuR and ARE mRNA using RNA electrophoretic mobility gel shift assay (EMSA) filter binding assay. Of 179 chemicals screened, three with a half-maximal inhibitory concentration (IC50) below 10 µM. The IC50 quercetin, b-40, b-41 were 1.4, 0.38, 6.21 µM, respectively, for Quercetin b-40 did not inhibit tristetraprolin When LPS-treated RAW264.7 cells...
We investigated the effects of a Leonurus japonicus ethanol extract (LJE) on nonalcoholic fatty liver disease (NAFLD). An in vitro model hepatic steatosis was treated with 1 mM free acid (FFA) HepG2 cells. vivo NAFLD established using C57BL/6 mice fed high-fat diet (HFD) and administered LJE (100 or 200 mg/kg) orally for 14 weeks. treatment suppressed lipid accumulation intracellular triglyceride levels significantly concentration-dependent manner Moreover, reduced expression sterol...
Ginsenosides, the secondary plant metabolites produced by Panax ginseng are responsible for enhancing effects on learning observed following treatment with ginseng. A number of studies have provided correlational evidence that cell proliferation and survival closely associated hippocampal-dependent tasks. In this study, to investigate beneficial ginsenoside Rh1 hippocampal cells learning, mice (6 months old) were administered at a dose 5 10 mg/kg/day period 3 months. Saline-treated used as...
Trimethyltin (TMT) is a potent neurotoxicant that affects various regions within the central nervous system, including neocortex, cerebellum, and hippocampus. In present study, ginsenoside Rd was investigated as candidate neuroprotective agent in primary hippocampal neuron culture mouse models. TMT induced neurotoxicity seven-day dose-dependent manner (2.5-10 µM). However, pre-treatment with 20 µg/ml for 24 h reversed toxic action. ICR mice were administered single injection of 2 mg/kg body...
Colitis is a well-known subtype of inflammatory bowel disease and caused by diverse factors. Previous research has shown that KIOM-MA elicits anti-inflammatory anti-allergic effects on various diseases. KIOM-MA-128, our novel herbal formula, was generated from using probiotics to improve the therapeutic efficacy. We investigated whether KIOM-MA-128 protective activity in mouse model acute colitis induced dextran sodium sulfate (DSS). DSS administered ICR mice drinking water. (125 or 250...
Chrysanthemum zawadskii has been proven to possess hair growth activity and used as treatment for loss. The aim of this study was provide a novel explanation the mechanism by which extracts (CZe) promote characterize affected follicle (HF) regions progression growth. n-butanol water fractions CZe were induction topical application backs C57BL/6 mice up 30 days. To investigate cell development during HF morphogenesis, bromodeoxyuridine-labeled skin sections detected using...
Pueraria lobata (Willd.) Ohwi, known as kudzu, is one of the most popular traditional medicines in Asian countries. It has been widely used a natural alternative to hormone replacement therapy for treating postmenopausal symptoms. This study aimed investigate estrogenic effect P. extract (PE) against osteoporosis ovariectomized (OVX) rats. OVX rats were treated with PE (25–1600 mg/kg) 8 weeks. Biochemical parameters, estradiol, and bone turnover markers (e.g., osteocalcin, C-terminal...
A wide range of plant foods and dietary supplements are able to modify the functioning central nervous system. In present study, we observed that oral administration ginsenoside Rh2 (10 mg/mL) for 3 weeks significantly improved spatial learning memory. Spatial memory was evaluated in mice by hippocampus-dependent tasks (Morris water maze test) immunohistochemical marker cell genesis bromodeoxyuridine. Ginsenoside treatment (30 days) promoted survival genesis. Further, enriched condition had...
IFN-γ has been shown to either up- or down-regulate the expression of specific TGF-β1-induced target genes. We investigated effect on IgA isotype expression. found that inhibited not only germ-line (GL) α transcription, but also secretion by TGF-β1-stimulated murine B cells. Overexpression Stat1 diminished TGF-β1-induced, Smad3/4-and Runx3-mediated GLα promoter activity. p300 increased activity, while its was abrogated co-transfected Stat1. interfered with Smad3:p300 interaction, likely due...