A5023209015- Transplantation: Methods and Outcomes
- SARS-CoV-2 and COVID-19 Research
- Cancer Immunotherapy and Biomarkers
- Cholangiocarcinoma and Gallbladder Cancer Studies
- COVID-19 Clinical Research Studies
- Reconstructive Surgery and Microvascular Techniques
- Genetic factors in colorectal cancer
- Tracheal and airway disorders
- Lymphatic System and Diseases
- Cancer Genomics and Diagnostics
- Polyomavirus and related diseases
- Lung Cancer Diagnosis and Treatment
- Congenital Diaphragmatic Hernia Studies
- Pleural and Pulmonary Diseases
- Cancer, Stress, Anesthesia, and Immune Response
- Lung Cancer Treatments and Mutations
- Liver physiology and pathology
- Lymphatic Disorders and Treatments
- Inflammatory mediators and NSAID effects
- Vascular Malformations and Hemangiomas
- Estrogen and related hormone effects
- Immune Cell Function and Interaction
- Surgical site infection prevention
- Renal Transplantation Outcomes and Treatments
- Inflammatory Biomarkers in Disease Prognosis
LMU Klinikum
2022-2025
Ludwig-Maximilians-Universität München
2022-2025
Medical University of Vienna
2015-2018
Comprehensive Cancer Center Vienna
2018
The presence of tumor-infiltrating lymphocytes (TILs) and tertiary lymphoid structures (TLSs) reflects an active inflammatory tumor microenvironment. High density TILs as well TLS is associated with improved survival in various solid cancer types. We aimed to describe the distribution pulmonary metastases (PMs) from primary colorectal (CRC) its correlation clinicopathological variables. Fifty-seven CRC metastasectomy specimen (PM) 31 matched were included. Cluster differentiation (CD)3+,...
Introduction Acute rejection is a significant risk factor for developing chronic lung allograft dysfunction. Current monitoring tools, transbronchial biopsies and HLA antibody determination, have limitations in detecting acute rejection. This study aims to explore the potential utility of donor-derived cell-free DNA (ddcfDNA) as non-invasive biomarker transplant recipients (LTR). Methods We developed molecular method based on digital droplet PCR determine total amount proportion ddcfDNA....
OBJECTIVESPulmonary metastasectomy (PM) has evolved to become a standard treatment for colorectal cancer lung metastases. However, biomarkers estimate the prognosis after PM are currently missing. We therefore investigated prognostic impact of inflammatory-related and scores in patients undergoing curative cancer.
Pulmonary metastasectomy is one of the cornerstones in treatment oligometastatic colorectal cancer (CRC). However, selection patients who benefit from a surgical resection difficult. Mutational profiling has become an essential part diagnosis and malignant disease. Despite this, comprehensive data on mutational profile CRC its clinical impact context pulmonary sparse. We therefore aimed to provide complete status metastases (PM) corresponding primary tumors by targeted next-generation...
The c-MET tyrosine kinase is known to play a key role in tumour promotion variety of cancers. prognostic significance pathway alterations has previously been described primary colorectal cancer (CRC). However, data on the expression and genetic mutational status CRC pulmonary metastases (PM) are lacking. We aimed assess clinical implications patients undergoing metastasectomy. From April 2009 November 2013, all with complete lung metastasectomy were included this study prospectively followed...
Pulmonary metastasectomy (PM) is a standard procedure in the treatment of stage IV colorectal cancer (CRC). In most centers indication for PM solely based on clinical factors without taking tumor biology into account. This results diverse outcomes ranging from long-term remission to early recurrence. Inflammation considered hallmark development and progression. On other hand accessibility CRC cells immune system reflects grade aggressiveness. We sought investigate impact cyclooxygenase-2...
Lung transplant recipients are at increased risk of severe disease following infection with acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) due to high-dose immunosuppressive drugs and the lung is main organ affected by Coronavirus 2019 (COVID-19). Several studies have confirmed SARS-CoV-2-related mortality morbidity in patients living allografts; however, detailed immunological SARS-CoV-2 early phase transplantation remain scarce.
There are various reconstructive methods after total sternectomy. Reproducibility is scarce due to overall small patient numbers. Therefore we present a standardized, interdisciplinary approach for thoracic and plastic surgery.