A5047475944- Cardiovascular Conditions and Treatments
- Congenital Heart Disease Studies
- Nitric Oxide and Endothelin Effects
- Cardiac Valve Diseases and Treatments
- Proteoglycans and glycosaminoglycans research
- Cardiovascular Function and Risk Factors
- Cell Adhesion Molecules Research
- Cardiac Arrhythmias and Treatments
- Vascular anomalies and interventions
- Platelet Disorders and Treatments
- Hormonal Regulation and Hypertension
- Heart Rate Variability and Autonomic Control
- Congenital heart defects research
- Veterinary Oncology Research
- Cardiac electrophysiology and arrhythmias
- Mechanical Circulatory Support Devices
- Cardiomyopathy and Myosin Studies
- Cardiovascular Effects of Exercise
- Blood groups and transfusion
- Atrial Fibrillation Management and Outcomes
- Stress Responses and Cortisol
- Cardiac pacing and defibrillation studies
- Cardiac tumors and thrombi
- Pulmonary Hypertension Research and Treatments
- Adipose Tissue and Metabolism
University of Edinburgh
2015-2024
Royal Edinburgh Hospital
2008-2024
Roslin Institute
2013-2023
British Heart Foundation
2015-2023
The Queen's Medical Research Institute
2018-2023
University of Liverpool
2008
Scotland's Rural College
2006
The benefit of pimobendan in delaying the progression preclinical dilated cardiomyopathy (DCM) Dobermans is not reported.That chronic oral administration to with DCM will delay onset CHF or sudden death and improve survival.Seventy-six client-owned recruited at 10 centers UK North America.The trial was a randomized, blinded, placebo-controlled, parallel group multicenter study. Dogs were allocated 1:1 ratio receive (Vetmedin capsules) visually identical placebo. composite primary endpoint...
Background Hypertrophic cardiomyopathy is the most prevalent heart disorder in cats and principal cause of cardiovascular morbidity mortality. Yet, impact preclinical disease unresolved. Hypothesis/Objectives Observational study to characterize survival with nonobstructive (HCM) obstructive (HOCM) hypertrophic apparently healthy (AH). Animals One thousand seven hundred thirty client‐owned (430 HCM; 578 HOCM; 722 AH). Methods Retrospective multicenter, longitudinal, cohort study. Cats from 21...
Abstract Although the origin of hepatitis C virus infections in humans remains undetermined, a close homolog this virus, termed canine hepacivirus (CHV) and found respiratory secretions dogs, provides evidence for wider distribution hepaciviruses mammals. We determined frequencies active infection among dogs other mammals United Kingdom. Samples from (46 respiratory, 99 plasma, 45 autopsy samples) were CHV negative by PCR. Screening 362 samples cats, horses, donkeys, rodents, pigs identified...
Non-primate hepacivirus (NPHV), equine pegivirus (EPgV) and Theiler's disease associated virus (TDAV) are newly discovered members of two genera in the Flaviviridae family, Hepacivirus Pegivirus respectively, that include human hepatitis C (HCV) (HPgV). To investigate their epidemiology, persistence clinical features infection, large cohorts horses other mammalian species were screened for NPHV, EPgV TDAV viraemia past exposure through serological assays NPHV EPgV-specific antibodies....
Objective: To determine the outcome, independent predictors of cardiac death, and Doppler-derived pressure gradient cut-off for predicting death in dogs with pulmonic stenosis, or without tricuspid regurgitation, that do not undergo balloon valvuloplasty valve surgery. Methods: Review medical records two UK referral centres between July 1997 October 2008 all cases stenosis had no Inclusion criteria included a diagnosis stenosis; spectral Doppler velocity greater than 1·6 m/s; characteristic...
Abstract Objective —To map the cellular distribution and phenotypic alteration of predominant stromal cell population throughout entire valve length dogs with myxomatous mitral disease (MMVD). Sample Population —31 complexes (ie, leaflets) collected from 4 clinically normal 27 MMVD varying severity. Procedures —A combination standard histologic immunohistochemical techniques was used to identify pathologic changes, presence mast cells, density cells expressing vimentin, desmin, A-smooth...
Epidemiologic knowledge regarding noncardiovascular and all-cause mortality in apparently healthy cats (AH) with preclinical hypertrophic cardiomyopathy (pHCM) is limited, hindering development of evidence-based healthcare guidelines.
O bjectives : To investigate the prognostic and diagnostic value of heart rate variability (HRV) using vasovagal tonus index (VVTI) in dogs suffering from idiopathic dilated cardiomyopathy (DCM). M ethods Electrocardiographic (ECG) recordings 369 patients presented to a referral centre between 1993 2006 were reviewed. R esults VVTI values calculated 132 dogs. Lower found International Small Animal Cardiac Health Council (ISACHC) failure (HF) class 2 3 compared with 1. was be positively...
The objective of this study was to determine the demographic, clinical and survival characteristics identify risk factors for mortality due tricuspid valve dysplasia in UK dogs. Records client-owned dogs diagnosed with at a referral centre were retrospectively reviewed. Only based on presence right-sided heart murmur identified prior one year age, confirmed Doppler echocardiography, included. Dogs concomitant cardiac diseases, pulmonary hypertension and/or trivial regurgitation excluded....
Key points Type 1 diabetes mellitus increases cardiovascular risk; hypertension amplifies this risk, while pressure natriuresis regulates long‐term blood pressure. We induced type in rats by streptozotocin injection and demonstrated a substantial impairment of natriuresis: acute did not increase renal medullary flow, tubular sodium reabsorption was downregulated, proximal tubule reabsorption, measured lithium clearance, unaffected. Insulin reduced glucose diabetic rats, rescued the response...
Abstract Background Insulin, insulin‐like growth factor‐1 (IGF‐1), and inflammation possibly are involved in cats with asymptomatic hypertrophic cardiomyopathy (aHCM). Objectives To evaluate echocardiography, morphology, cardiac inflammatory markers, insulin IGF‐1 aHCM. Animals Fifty‐one client‐owned Methods Observational descriptive study. Variables (body weight [BW], body condition score [BCS], serum concentrations of N‐terminal pro‐B‐type natriuretic peptide [NT‐proBNP], ultra‐sensitive...
A 7-month-old intact female Cocker Spaniel weighing 7.7 kg was presented for investigation of a heart base murmur. The dog free from clinical signs. There grade IV/VI pansystolic murmur localized over the left base. Femoral pulses were normal volume and character. Routine serum biochemistry hematology unremarkable. Echocardiography showed increased ventricular internal end diastolic diameter (LVIDD) at 4.2 cm (reference range, 2.3–3.4 cm1) systolic (LVIDS) 2.8 1.4–2.4 cm1), mildly atrial...
Abstract Objective —To map aspects of the innervation mitral valve complex and determine any association with development or progression myxomatous disease (MMVD) in dogs. Sample Population —Septal leaflets from 11 dogs aged 6 months to > 10 years. Procedures —Expression protein gene product 9.5 (general neuronal marker), tyrosine hydroxylase (adrenergic vasoactive intestinal peptide (parasympathetic calcitonin gene–related (sensory marker) was assessed by use a standard...