A5089516516- Fuel Cells and Related Materials
- Membrane-based Ion Separation Techniques
- 3D Printing in Biomedical Research
- Advanced Battery Technologies Research
- Electrocatalysts for Energy Conversion
- Advanced battery technologies research
- Electrospun Nanofibers in Biomedical Applications
- Advanced Battery Materials and Technologies
- Conducting polymers and applications
- CAR-T cell therapy research
- Innovative Microfluidic and Catalytic Techniques Innovation
- Nanoparticle-Based Drug Delivery
- Extracellular vesicles in disease
- Mesenchymal stem cell research
- Bone Tissue Engineering Materials
- Cellular Mechanics and Interactions
- Nanoplatforms for cancer theranostics
- Immunotherapy and Immune Responses
- RNA Interference and Gene Delivery
- Tissue Engineering and Regenerative Medicine
- Periodontal Regeneration and Treatments
- Microfluidic and Bio-sensing Technologies
- Microfluidic and Capillary Electrophoresis Applications
- Polymer Surface Interaction Studies
- Wound Healing and Treatments
University of California, Los Angeles
2016-2025
Samueli Institute
2021-2024
California NanoSystems Institute
2016-2021
Los Angeles City College
2020
Georgia Institute of Technology
2013-2019
Fraunhofer USA
2019
Amirkabir University of Technology
2008-2016
École Polytechnique Fédérale de Lausanne
2010-2016
Royan Institute
2015-2016
Academic Center for Education, Culture and Research
2015-2016
Cell-laden hydrogels are widely used in tissue engineering and regenerative medicine. However, many of these not optimized for use the oral environment, where they exposed to blood saliva. To address challenges, we engineered an alginate-based adhesive, photocrosslinkable, osteoconductive hydrogel biomaterial (AdhHG) with tunable mechanical properties. The was as injectable mesenchymal stem cell (MSC) delivery vehicle craniofacial bone applications. Subcutaneous implantation mice confirmed...
We present a microfluidic platform for the synthesis of monodisperse chitosan based nanoparticles via self-assembly at physiological pH. The resultant are shown to encapsulate hydrophobic anticancer drugs while providing sustainable release profile with high tunability.
Periodontitis is a common chronic inflammatory disease that affects tooth-supporting tissues. We engineer multifunctional periodontal membrane for the guided tissue regeneration of lost The major drawback current membranes lack properties. Here, series nanofibrous based on poly(ε-caprolactone) with tunable biochemical and biophysical properties were developed regeneration. engineered surface coated using biomimetic polydopamine to promote adhesion therapeutic proteins cells. demonstrate...
The use of solvent‐free microfluidics to fine‐tune the physical and chemical properties chitosan nanoparticles for drug delivery is demonstrated. Nanoparticle self‐assembly driven by pH changes in a water environment, which increases biocompatibility avoiding organic solvent contamination common with traditional techniques. Controlling time mixing (2.5–75 ms) during nanoparticle enables us adjust size surface potential order maximize cellular uptake, turn dramatically effectiveness. compact...
Alginate is a biopolymer with favorable pH-sensitive properties for oral delivery of peptides and proteins. However, conventional alginate nanogels have limitations such as low encapsulation efficiency because drug leaching during bead preparation burst release in high pH values. These shortcomings originate from large pore size the nanogels. In this work, we proposed an on-chip hydrodynamic flow focusing approach synthesis adjustable to achieve fine-tunable profile encapsulated bioactive...
Abstract Intramyocardial injection of hydrogels offers great potential for treating myocardial infarction (MI) in a minimally invasive manner. However, traditional bulk generally lack microporous structures to support rapid tissue ingrowth and biochemical signals prevent fibrotic remodeling toward heart failure. To address such challenges, novel drug‐releasing annealed particle (drugMAP) system is developed by encapsulating hydrophobic drug‐loaded nanoparticles into microgel building blocks...
A microfluidics approach to synthesize core-shell nanocarriers with high pH tunability is described. The sacrificial shell protects the core layer drugs and prevents their release in severe conditions of gastrointestinal tract, while allowing for drug proximity a tumor. proposed nanoparticulate drug-delivery system designed oral administration cancer therapeutics.
A microfluidic platform is developed for the synthesis of monodisperse, 100 nm, chitosan based nanoparticles using nanogelation with ATP. The resulting tuned and enhanced transport electrochemical properties Nafion nanocomposite membranes, which highly favorable fuel cell applications.
Serotonin-based nanoparticles represent a class of previously unexplored multifunctional nanoplatforms with potential biomedical applications. Serotonin, under basic conditions, self-assembles into monodisperse via autoxidation serotonin monomers. To demonstrate applications polyserotonin for cancer therapeutics, we show that these particles are biocompatible, exhibit photothermal effects when exposed to near-infrared radiation, and load the chemotherapeutic drug doxorubicin, releasing it...
Montmorillonite nanolayers were treated with chitosan sulfate, as a functional biocompatibilizer, and then exfoliated in matrix to design nanohybrid membranes for potential wound dressing applications enhanced physical, mechanical antibacterial properties.
Periodontal disease begins as an inflammatory response to a bacterial biofilm deposited around the teeth, which over time leads destruction of tooth-supporting structures and consequently tooth loss. Conventional treatment strategies show limited efficacy in promoting regeneration damaged periodontal tissues. Here, delivery platform is developed for small extracellular vesicles (sEVs) derived from gingival mesenchymal stem cells (GMSCs) treat periodontitis. EVs can achieve comparable...
Poly(ether ether ketone) (PEEK) was sulfonated at various degrees with sulfuric acid and dissolved in N, N-dimethylacetamide (DMAc). Montmorillonite (MMT) clay mixed this solution solvent-casted on a glass plate. A Fourier transfer infrared (FTIR) experiment of samples showed O−H vibration 3490 cm −1 SO peaks 1085 1100−1300 −1. Thermogravimetry analyzer (TGA) experiments revealed thermal degradation above 240 °C. X-ray diffraction (XRD) confirmed almost zero crystallinity for PEEK/MMT. When...
Abstract In the present study, a series of bioresource polyelectrolytes based on chitosan were synthesized and assessed for applicability in direct methanol fuel cells (DMFCs). A binary cross‐linking agent (sulfosuccinic acid/glutaraldehyde) was used structural modification membranes comprising various amounts sulfosuccinic acid (0, 8, 12, 16 wt% SSA/wt chitosan) prepared. It found that by increasing sulfonate groups' content up to wt%, proton conductivity permeability properties reach...