A5038667155- Antimicrobial Peptides and Activities
- Bacteriophages and microbial interactions
- Viral gastroenteritis research and epidemiology
- Helicobacter pylori-related gastroenterology studies
- Antibiotic Resistance in Bacteria
- Healthcare and Venom Research
- Bee Products Chemical Analysis
- Brucella: diagnosis, epidemiology, treatment
- Viral Infections and Vectors
- Salmonella and Campylobacter epidemiology
- Galectins and Cancer Biology
- Advancements in Transdermal Drug Delivery
- IL-33, ST2, and ILC Pathways
- vaccines and immunoinformatics approaches
- Monoclonal and Polyclonal Antibodies Research
- Ginseng Biological Effects and Applications
- Phytochemical compounds biological activities
- Cancer, Stress, Anesthesia, and Immune Response
- Echinoderm biology and ecology
- Advanced biosensing and bioanalysis techniques
- Bacterial biofilms and quorum sensing
- Polysaccharides and Plant Cell Walls
- Immunotherapy and Immune Responses
- Polyamine Metabolism and Applications
- CRISPR and Genetic Engineering
Biotechnology Research Center
2022-2025
Islamic Azad University South Tehran Branch
2023-2025
Islamic Azad University of Shahrekord
2022-2024
We aim to assess the antibacterial and anti-biofilm properties of Niosome-encapsulated Imipenem. After isolating Staphylococcus epidermidis isolates determining their microbial sensitivity, ability form biofilms was examined using plate microtiter assay. Various formulations Imipenem were prepared thin-film hydration method, Minimum Biofilm Inhibitory Concentration (MBIC) (MIC) determined, biofilm genes expression examined. Drug formulations' toxicity effect on HDF cells determined MTT Out...
Developing adjuvant vaccines to combat rising multidrug-resistant (MDR) Acinetobacter baumannii (A. baumannii) infections is a promising and cost-effective approach. The aim of this analysis was construct pDNA-CPG C274-adjuvant nano-vaccine investigate its immunogenicity protection in BALB/c mice. CPG ODN C274 chemically synthesized cloned into pcDNA3.1( +), the cloning verified using PCR BamHI/EcoRV restriction enzyme digestion. Then, utilizing complex coacervation approach, encapsulated by...
Abstract Background Helicobacter pylori (H. Pylori), is an established causative factor for the development of gastric cancer and induction persistent stomach infections that may lead to peptic ulcers. In recent decades, several endeavours have been undertaken develop a vaccine H. , although none advanced clinical phase. The successful hindered by particular challenges, such as absence secure mucosal vaccines enhance local immune responses, identified antigens are effective in vaccinations,...
Pharmaceutical companies worldwide are scrambling to develop new ways combat cancer and microbiological pathogens. The goal of this research was investigate the antibacterial, anticancer, apoptosis effects novel niosomal formulated Persian Gulf Sea cucumber extracts (SCEs). methanolic were prepared encapsulated in niosome nanoparticles using thin-film hydration. compound made up Span 60 Tween blended with cholesterol a 3:3:4 M ratios. Characterization niosome-encapsulated SCE evaluated by...
Abstract Most gastric cancers (GC) are thought to be caused by Helicobacter pylori ( H. ) infections. However, there is mounting evidence that GC patients with positive status have improved prognoses. The -induced cellular immune reaction may inhibit cancer. In this study, BALB/c mice were immunized using recombinant plasmids encode the ureF gene of . Purified functional splenic CD3 + T lymphocytes used study anticancer effects in vitro and vivo immunological state ongoing infection mimicked...
Abstract Background Colorectal cancer (CRC), now the second most prevalent malignant tumor worldwide, is more in young adults. In recent decades, there has been progress creating anti-colorectal medications, including cytotoxic compounds. Objectives Novel anticancer drugs are needed to surmount existing obstacles. A study investigated effectiveness of novel formulations preventing colorectal cancer. Methods During this study, we assessed a new kind niosome called cyclo-Gly-L-DOPA...
A major health and financial burden in the chicken sector is salmonella infection. It difficult to create an oral vaccination that can provide strong intestinal mucosal immunity birds, particularly cross-protection against several Salmonella serotypes. As a result, poultry industry needs powerful platform uses live bacterial vectors prevent various The genetically engineered L. lactis was given orally birds as vaccine after multi-epitope vector created using reverse vaccinology technique....
Chitosan nanoparticles (CSNP) are becoming a popular alternative for delivering nucleic acids to tissues gene transfer (gene therapy). The size and morphology of these biodegradable nano-carriers adjustable, their positive charge allows them interact strongly with negatively charged acids.This study aimed fabricate characterize pcDNA3.1 (+) plasmid (pDNA) CSNP complexes determine the location in vehicles.The characteristics pDNA/CSNP complex after production were investigated by SEM, XRD,...
Even though Helicobacter pylori (H. pylori) is a serious pathogen, its origin unknown. Poultry (Chicken, Turkey, Quebec, Goose, and Ostrich) are consumed as regular protein source by large number of people across the world; therefore, sanitary ways delivering poultry for food important global health. As result, we looked at distribution pathogenicity cagA, vacA, babA2, oipA, iceA in H. isolates meat, well their antimicrobial resistance. Wilkins Chalgren anaerobic bacterial medium was used to...
Major viral infections, such as Newcastle disease virus, infectious bronchitis avian influenza and bursal inflict significant injury to small poultry tremendous economic damage the sector. This research aims develop a multiplex reverse transcriptase polymerase chain reaction (m-RT-PCR) approach simultaneously determine these important pathogens. The conserved segment of various genetic sequences was used design synthesize specific primers. Moreover, positive controls, recombinant vectors...