A5067189761- Mesenchymal stem cell research
- Oral microbiology and periodontitis research
- MicroRNA in disease regulation
- Bacteriophages and microbial interactions
- Antimicrobial Peptides and Activities
- Advanced Drug Delivery Systems
- Gastrointestinal motility and disorders
- Electrospun Nanofibers in Biomedical Applications
- Biotin and Related Studies
- Probiotics and Fermented Foods
- Tissue Engineering and Regenerative Medicine
- Antifungal resistance and susceptibility
- Cancer-related molecular mechanisms research
- Barrier Structure and Function Studies
- Biochemical and Structural Characterization
- Microbial infections and disease research
- Molecular Junctions and Nanostructures
- Polymer Surface Interaction Studies
- Polydiacetylene-based materials and applications
- Bacterial Identification and Susceptibility Testing
- Pluripotent Stem Cells Research
- Advanced Chemical Sensor Technologies
- Dental materials and restorations
- Cell Adhesion Molecules Research
- Olfactory and Sensory Function Studies
University of Rostock
2017-2024
Institute of Medical Microbiology and Hygiene
2019-2022
Universitätsmedizin Rostock
2019
University Medical Center
2018
Alterations in the gut microbiota composition play a crucial role pathogenesis of inflammatory bowel disease (IBD) as specific commensal bacterial species are underrepresented IBD patients. In this study, we examined therapeutic potential three species, Faecalibacterium prausnitzii (F. prausnitzii), Roseburia intestinalis (R. intestinalis) and Bacteroides faecis (B. faecis) an vitro model intestinal inflammation, by using differentiated Caco-2 HT29-MTX cells, stimulated with pro-inflammatory...
Abstract Periodontitis is a chronic inflammatory and tissue‐destructive disease. Since the polymicrobiome in oral cavity makes it difficult to treat, novel therapeutic strategies are required. Hydrogels based on self‐assembling peptides (SAP) can be suitable candidates for periodontal therapy due their injectability, biocompatibility, cargo‐loading capacity, tunable physicochemical mechanical properties. In this study, two SAP hydrogels (P11‐4 P11‐28/29) examined intrinsic antimicrobial...
Metabolic characterization of human adipose tissue-derived mesenchymal stromal/stem cells (ASCs) is importance in stem cell research. The monitoring the status often requires destruction. An analysis volatile organic compounds (VOCs) headspace above cultures might be a noninvasive and nondestructive alternative to vitro analysis. Furthermore, VOC analyses permit new insight into cellular metabolism due their view on compounds. Therefore, aim our study was compare profiles nondifferentiating...
Inflammation triggered by bacterial biofilms in the surrounding tissue is a major etiological factor for peri-implantitis and subsequent implant failure. However, little known about direct effects of corrosion recolonization on failure PURPOSE: To investigate influence oral commensals titanium surfaces.Streptococcus sanguinis (S. sanguinis) Porphyromonas gingivalis (P. gingivalis), which are key bacteria biofilm formation, were cultured commercially pure titanium-aluminum-vanadium (Ti6Al4V)...
Streptavidin is a 58 kDa tetrameric protein with the highest known affinity to biotin wide range of applications in bionanotechnology and molecular biology. Dissolved streptavidin stable at broad temperature, pH, proteolytic enzymes exhibits low non-specific binding. In this study, monolayer was assembled directly on biotinylated TiO2 -surface investigate its stability against digestion suppression initial bacterial adsorption Escherichia coli, Bacillus subtilis, Streptococcus intermedius....
Multipotent adult mesenchymal stromal cells (MSCs) could represent an elegant source for the generation of patient-specific cardiomyocytes needed regenerative medicine, cardiovascular research, and pharmacological studies. However, differentiation MSC into a cardiac lineage is challenging compared to embryonic stem or induced pluripotent cells. Here we used non-integrative methods, including microRNA mRNA, reprogramming derived from bone marrow, dental follicle, adipose tissue. We found that...
Rheumatoid arthritis (RA) and periodontitis (PD) are chronic inflammatory diseases that appear to occur in tandem. However, the mutual impact PD exerts on RA vice versa has not yet been defined. To address this issue, we set up an animal model analyzed how two prime inducers of periodontitis— Porphyromonas gingivalis (Pg) Aggregatibacter actinomycetemcomitans (Aa)– differ their pathogenic potential. Our experimental setup included collagen induced (CIA) mouse, oral inoculation with Pg or Aa...
Application of bacteriophages is increasingly being implemented in clinical therapies. Prior susceptibility testing should be regarded as mandatory, but standards are lacking. The objective this research was to develop a highly standardized methodology facilitate phage (PST) microbiology routine laboratories. Therefore, EUCAST methods established for single disk-based antibiotic (AST) were adapted. In first step, basic parameters evaluated using well-studied Escherichia T4-Escherichia coli...
To date, several stem cell types at different developmental stages are in the focus for treatment of degenerative diseases. Yet, certain aspects, such as initial massive death and low therapeutic effects, impaired their broad clinical translation. Genetic engineering cells prior to transplantation emerged a promising method optimize effects. However, safe efficient gene delivery systems still lacking. Therefore, development suitable methods may provide an approach resolve current challenges...
Probiotic microorganisms are used in a variety of food supplements and medical formulations to promote human health. In periodontal therapy, probiotics mainly the form gels, tablets or rinses that often tend leak from pocket, resulting strongly reduced therapeutic effect. this pilot vitro study, we present biodegradable alginate-based particles as an alternative, highly efficient system for delivery probiotic bacteria inflammation site. For purpose, Lactococcus (L.) lactis was encapsulated...